Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease
Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling in animal models of chronic obs...
Gespeichert in:
| Veröffentlicht in: | PloS one 2018-01, Vol.13 (1), p.e0190628-e0190628 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0190628 |
|---|---|
| container_issue | 1 |
| container_start_page | e0190628 |
| container_title | PloS one |
| container_volume | 13 |
| creator | Paul, Tanja Salazar-Degracia, Anna Peinado, Victor I Tura-Ceide, Olga Blanco, Isabel Barreiro, Esther Barberà, Joan A |
| description | Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling in animal models of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the effects of sGC stimulation on oxidative stress in the plasma of guinea pigs chronically exposed to cigarette smoke (CS).
Guinea pigs were exposed to CS or sham for three months, and received either the sGC stimulator BAY 41-2272 or vehicle. Body weight was measured weekly; and markers of oxidative stress in plasma, and airspace size and inflammatory cell infiltrate in lung tissue were analyzed at the end of the study. Compared to sham-exposed guinea pigs, CS-exposed animals gained less body weight and showed higher plasma levels of nitrated tyrosine residues (3-NT), 4-hydroxynonenal (4-HNE), and 8-hydroxydeoxyguanosine (8-OHdG). Treatment with the sGC stimulator led to a body weight gain in the CS-exposed guinea pigs similar to non-exposed and attenuated the increase in 3-NT and 4-HNE. Plasma levels of 3-NT correlated with the severity of inflammatory cell infiltrate in the lung.
Stimulation of sGC prevents oxidative stress induced by CS exposure and is associated with an attenuated inflammatory response in the lung. |
| doi_str_mv | 10.1371/journal.pone.0190628 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2390647498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A521670730</galeid><doaj_id>oai_doaj_org_article_94d74250989f4fe78d15b1e729d93eb4</doaj_id><sourcerecordid>A521670730</sourcerecordid><originalsourceid>FETCH-LOGICAL-c734t-8c30714eb2e57f5bebea7b3579c7b98d87df9c5844ab8efdecbfa32f4bb733573</originalsourceid><addsrcrecordid>eNqNk91u1DAQhSMEoqXwBggiISG42MWO7XV8g1SVv0qViihwa9nOZNeVN17spGrfnsluWnVRL1AUxRl_c2wfzxTFS0rmlEn64TIOqTNhvokdzAlVZFHVj4pDqlg1W1SEPb43Piie5XxJiGD1YvG0OKgUI5wyelj0FzEMNkC5HEx3E0wPpbtxwWQoc-_XA0Z87MoEzeAgl_HaNxi5GmcT5Fz6roTrDSS_hq43oTxZpdh5V55bBAa3Rb8PYR07k27KTz4DSj8vnrQmZHgxfY-KX18-_zz5Njs7_3p6cnw2c5LxflY7RiTlYCsQshUWLBhpmZDKSavqppZNq5yoOTe2hrYBZ1vDqpZbKxli7Kh4vdPdhJj1ZFjWFUOzuOSqRuJ0RzTRXOoNHgO3qaPxehuIaalN6r0LoBVvJK8EUbVqeQuybqiwFGSlGsXActT6OK022DU0Dg1JJuyJ7s90fqWX8UoLKfAQCgXoTsDlwekEDpIz_Tbx7md8KyIrjdYIRTHn3bRoin8GyL1e--wgBNNBHLKmuF3BBCMj-uYf9GFHJmpp8NC-ayPu1Y2i-lhUdCGJZASp-QMUPg2svcOKbD3G9xLe7yUg08N1vzRDzvr04sf_s-e_99m399gVmNCvMpb0WLV5H-STuSnmnKC9uxhK9NhQt27osaH01FCY9ur-pd4l3XYQ-wsS1x3Z</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2390647498</pqid></control><display><type>article</type><title>Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>Recercat</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Paul, Tanja ; Salazar-Degracia, Anna ; Peinado, Victor I ; Tura-Ceide, Olga ; Blanco, Isabel ; Barreiro, Esther ; Barberà, Joan A</creator><creatorcontrib>Paul, Tanja ; Salazar-Degracia, Anna ; Peinado, Victor I ; Tura-Ceide, Olga ; Blanco, Isabel ; Barreiro, Esther ; Barberà, Joan A</creatorcontrib><description>Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling in animal models of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the effects of sGC stimulation on oxidative stress in the plasma of guinea pigs chronically exposed to cigarette smoke (CS).
Guinea pigs were exposed to CS or sham for three months, and received either the sGC stimulator BAY 41-2272 or vehicle. Body weight was measured weekly; and markers of oxidative stress in plasma, and airspace size and inflammatory cell infiltrate in lung tissue were analyzed at the end of the study. Compared to sham-exposed guinea pigs, CS-exposed animals gained less body weight and showed higher plasma levels of nitrated tyrosine residues (3-NT), 4-hydroxynonenal (4-HNE), and 8-hydroxydeoxyguanosine (8-OHdG). Treatment with the sGC stimulator led to a body weight gain in the CS-exposed guinea pigs similar to non-exposed and attenuated the increase in 3-NT and 4-HNE. Plasma levels of 3-NT correlated with the severity of inflammatory cell infiltrate in the lung.
Stimulation of sGC prevents oxidative stress induced by CS exposure and is associated with an attenuated inflammatory response in the lung.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0190628</identifier><identifier>PMID: 29304131</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>4-Hydroxynonenal ; 8-Hydroxydeoxyguanosine ; Airspace ; Analysis ; Animal models ; Animals ; Biology and Life Sciences ; Biomarkers ; Biomedical research ; Body weight ; Body weight gain ; Cell size ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Cigarette smoke ; Complications and side effects ; Cyclic GMP ; Development and progression ; Disease ; Drugs ; Emphysema ; Enzymes ; Exposure ; Genetic aspects ; Guanosine ; Guanylate cyclase ; Guinea pigs ; Hospitals ; Inflammation ; Inflammatory response ; Laboratories ; Lung cancer ; Lung diseases ; Lungs ; Malalties de l'aparell respiratori ; Medicaments ; Medicine ; Medicine and Health Sciences ; Musculoskeletal system ; Nitric oxide ; Obstructive lung disease ; Oxidation ; Oxidative stress ; Physiological aspects ; Plasma levels ; Proteins ; Research and Analysis Methods ; Respiratory diseases ; Respiratory organs diseases ; Signal transduction ; Smoke ; Smoking ; Smooth muscle ; Stimulation ; Stimulators ; Tyrosine</subject><ispartof>PloS one, 2018-01, Vol.13 (1), p.e0190628-e0190628</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Paul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>cc-by (c) Paul, Tanja et al., 2018 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><rights>2018 Paul et al 2018 Paul et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c734t-8c30714eb2e57f5bebea7b3579c7b98d87df9c5844ab8efdecbfa32f4bb733573</citedby><cites>FETCH-LOGICAL-c734t-8c30714eb2e57f5bebea7b3579c7b98d87df9c5844ab8efdecbfa32f4bb733573</cites><orcidid>0000-0001-9793-9433</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755849/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755849/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,26951,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29304131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paul, Tanja</creatorcontrib><creatorcontrib>Salazar-Degracia, Anna</creatorcontrib><creatorcontrib>Peinado, Victor I</creatorcontrib><creatorcontrib>Tura-Ceide, Olga</creatorcontrib><creatorcontrib>Blanco, Isabel</creatorcontrib><creatorcontrib>Barreiro, Esther</creatorcontrib><creatorcontrib>Barberà, Joan A</creatorcontrib><title>Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling in animal models of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the effects of sGC stimulation on oxidative stress in the plasma of guinea pigs chronically exposed to cigarette smoke (CS).
Guinea pigs were exposed to CS or sham for three months, and received either the sGC stimulator BAY 41-2272 or vehicle. Body weight was measured weekly; and markers of oxidative stress in plasma, and airspace size and inflammatory cell infiltrate in lung tissue were analyzed at the end of the study. Compared to sham-exposed guinea pigs, CS-exposed animals gained less body weight and showed higher plasma levels of nitrated tyrosine residues (3-NT), 4-hydroxynonenal (4-HNE), and 8-hydroxydeoxyguanosine (8-OHdG). Treatment with the sGC stimulator led to a body weight gain in the CS-exposed guinea pigs similar to non-exposed and attenuated the increase in 3-NT and 4-HNE. Plasma levels of 3-NT correlated with the severity of inflammatory cell infiltrate in the lung.
Stimulation of sGC prevents oxidative stress induced by CS exposure and is associated with an attenuated inflammatory response in the lung.</description><subject>4-Hydroxynonenal</subject><subject>8-Hydroxydeoxyguanosine</subject><subject>Airspace</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomedical research</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Cell size</subject><subject>Chronic obstructive lung disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarette smoke</subject><subject>Complications and side effects</subject><subject>Cyclic GMP</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Drugs</subject><subject>Emphysema</subject><subject>Enzymes</subject><subject>Exposure</subject><subject>Genetic aspects</subject><subject>Guanosine</subject><subject>Guanylate cyclase</subject><subject>Guinea pigs</subject><subject>Hospitals</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Laboratories</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Malalties de l'aparell respiratori</subject><subject>Medicaments</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Musculoskeletal system</subject><subject>Nitric oxide</subject><subject>Obstructive lung disease</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Physiological aspects</subject><subject>Plasma levels</subject><subject>Proteins</subject><subject>Research and Analysis Methods</subject><subject>Respiratory diseases</subject><subject>Respiratory organs diseases</subject><subject>Signal transduction</subject><subject>Smoke</subject><subject>Smoking</subject><subject>Smooth muscle</subject><subject>Stimulation</subject><subject>Stimulators</subject><subject>Tyrosine</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>XX2</sourceid><sourceid>DOA</sourceid><recordid>eNqNk91u1DAQhSMEoqXwBggiISG42MWO7XV8g1SVv0qViihwa9nOZNeVN17spGrfnsluWnVRL1AUxRl_c2wfzxTFS0rmlEn64TIOqTNhvokdzAlVZFHVj4pDqlg1W1SEPb43Piie5XxJiGD1YvG0OKgUI5wyelj0FzEMNkC5HEx3E0wPpbtxwWQoc-_XA0Z87MoEzeAgl_HaNxi5GmcT5Fz6roTrDSS_hq43oTxZpdh5V55bBAa3Rb8PYR07k27KTz4DSj8vnrQmZHgxfY-KX18-_zz5Njs7_3p6cnw2c5LxflY7RiTlYCsQshUWLBhpmZDKSavqppZNq5yoOTe2hrYBZ1vDqpZbKxli7Kh4vdPdhJj1ZFjWFUOzuOSqRuJ0RzTRXOoNHgO3qaPxehuIaalN6r0LoBVvJK8EUbVqeQuybqiwFGSlGsXActT6OK022DU0Dg1JJuyJ7s90fqWX8UoLKfAQCgXoTsDlwekEDpIz_Tbx7md8KyIrjdYIRTHn3bRoin8GyL1e--wgBNNBHLKmuF3BBCMj-uYf9GFHJmpp8NC-ayPu1Y2i-lhUdCGJZASp-QMUPg2svcOKbD3G9xLe7yUg08N1vzRDzvr04sf_s-e_99m399gVmNCvMpb0WLV5H-STuSnmnKC9uxhK9NhQt27osaH01FCY9ur-pd4l3XYQ-wsS1x3Z</recordid><startdate>20180105</startdate><enddate>20180105</enddate><creator>Paul, Tanja</creator><creator>Salazar-Degracia, Anna</creator><creator>Peinado, Victor I</creator><creator>Tura-Ceide, Olga</creator><creator>Blanco, Isabel</creator><creator>Barreiro, Esther</creator><creator>Barberà, Joan A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>XX2</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9793-9433</orcidid></search><sort><creationdate>20180105</creationdate><title>Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease</title><author>Paul, Tanja ; Salazar-Degracia, Anna ; Peinado, Victor I ; Tura-Ceide, Olga ; Blanco, Isabel ; Barreiro, Esther ; Barberà, Joan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c734t-8c30714eb2e57f5bebea7b3579c7b98d87df9c5844ab8efdecbfa32f4bb733573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>4-Hydroxynonenal</topic><topic>8-Hydroxydeoxyguanosine</topic><topic>Airspace</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomedical research</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Cell size</topic><topic>Chronic obstructive lung disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cigarette smoke</topic><topic>Complications and side effects</topic><topic>Cyclic GMP</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Drugs</topic><topic>Emphysema</topic><topic>Enzymes</topic><topic>Exposure</topic><topic>Genetic aspects</topic><topic>Guanosine</topic><topic>Guanylate cyclase</topic><topic>Guinea pigs</topic><topic>Hospitals</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Laboratories</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Malalties de l'aparell respiratori</topic><topic>Medicaments</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Musculoskeletal system</topic><topic>Nitric oxide</topic><topic>Obstructive lung disease</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Physiological aspects</topic><topic>Plasma levels</topic><topic>Proteins</topic><topic>Research and Analysis Methods</topic><topic>Respiratory diseases</topic><topic>Respiratory organs diseases</topic><topic>Signal transduction</topic><topic>Smoke</topic><topic>Smoking</topic><topic>Smooth muscle</topic><topic>Stimulation</topic><topic>Stimulators</topic><topic>Tyrosine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paul, Tanja</creatorcontrib><creatorcontrib>Salazar-Degracia, Anna</creatorcontrib><creatorcontrib>Peinado, Victor I</creatorcontrib><creatorcontrib>Tura-Ceide, Olga</creatorcontrib><creatorcontrib>Blanco, Isabel</creatorcontrib><creatorcontrib>Barreiro, Esther</creatorcontrib><creatorcontrib>Barberà, Joan A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paul, Tanja</au><au>Salazar-Degracia, Anna</au><au>Peinado, Victor I</au><au>Tura-Ceide, Olga</au><au>Blanco, Isabel</au><au>Barreiro, Esther</au><au>Barberà, Joan A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-01-05</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>e0190628</spage><epage>e0190628</epage><pages>e0190628-e0190628</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling in animal models of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the effects of sGC stimulation on oxidative stress in the plasma of guinea pigs chronically exposed to cigarette smoke (CS).
Guinea pigs were exposed to CS or sham for three months, and received either the sGC stimulator BAY 41-2272 or vehicle. Body weight was measured weekly; and markers of oxidative stress in plasma, and airspace size and inflammatory cell infiltrate in lung tissue were analyzed at the end of the study. Compared to sham-exposed guinea pigs, CS-exposed animals gained less body weight and showed higher plasma levels of nitrated tyrosine residues (3-NT), 4-hydroxynonenal (4-HNE), and 8-hydroxydeoxyguanosine (8-OHdG). Treatment with the sGC stimulator led to a body weight gain in the CS-exposed guinea pigs similar to non-exposed and attenuated the increase in 3-NT and 4-HNE. Plasma levels of 3-NT correlated with the severity of inflammatory cell infiltrate in the lung.
Stimulation of sGC prevents oxidative stress induced by CS exposure and is associated with an attenuated inflammatory response in the lung.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29304131</pmid><doi>10.1371/journal.pone.0190628</doi><tpages>e0190628</tpages><orcidid>https://orcid.org/0000-0001-9793-9433</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-01, Vol.13 (1), p.e0190628-e0190628 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2390647498 |
| source | Public Library of Science (PLoS) Journals Open Access; Recercat; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | 4-Hydroxynonenal 8-Hydroxydeoxyguanosine Airspace Analysis Animal models Animals Biology and Life Sciences Biomarkers Biomedical research Body weight Body weight gain Cell size Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoke Complications and side effects Cyclic GMP Development and progression Disease Drugs Emphysema Enzymes Exposure Genetic aspects Guanosine Guanylate cyclase Guinea pigs Hospitals Inflammation Inflammatory response Laboratories Lung cancer Lung diseases Lungs Malalties de l'aparell respiratori Medicaments Medicine Medicine and Health Sciences Musculoskeletal system Nitric oxide Obstructive lung disease Oxidation Oxidative stress Physiological aspects Plasma levels Proteins Research and Analysis Methods Respiratory diseases Respiratory organs diseases Signal transduction Smoke Smoking Smooth muscle Stimulation Stimulators Tyrosine |
| title | Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T18%3A12%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Soluble%20guanylate%20cyclase%20stimulation%20reduces%20oxidative%20stress%20in%20experimental%20Chronic%20Obstructive%20Pulmonary%20Disease&rft.jtitle=PloS%20one&rft.au=Paul,%20Tanja&rft.date=2018-01-05&rft.volume=13&rft.issue=1&rft.spage=e0190628&rft.epage=e0190628&rft.pages=e0190628-e0190628&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0190628&rft_dat=%3Cgale_plos_%3EA521670730%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2390647498&rft_id=info:pmid/29304131&rft_galeid=A521670730&rft_doaj_id=oai_doaj_org_article_94d74250989f4fe78d15b1e729d93eb4&rfr_iscdi=true |