CLCA2 expression is associated with survival among African American women with triple negative breast cancer

Black/African American (AA) women are twice as likely to be diagnosed with triple negative breast cancer (TNBC) compared to whites, an aggressive breast cancer subtype associated with poor prognosis. There are no routinely used targeted clinical therapies for TNBC; thus there is a clear need to iden...

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Veröffentlicht in:	PloS one 2020-04, Vol.15 (4), p.e0231712
Hauptverfasser:	Purrington, Kristen S, Knight, 3rd, Jimmie, Dyson, Gregory, Ali-Fehmi, Rouba, Schwartz, Ann G, Boerner, Julie L, Bandyopadhyay, Sudeshna
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Biology and Life Sciences Biomarkers Biomarkers, Tumor Black or African American Breast cancer Cancer therapies Chloride channels (calcium-gated) Chloride Channels - genetics Chloride Channels - metabolism Clinical outcomes Cohort Studies Confidence intervals Datasets DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene expression Health hazards Heterogeneity Humans Identification methods Kaplan-Meier Estimate Markers Medical diagnosis Medical prognosis Medicine Medicine and Health Sciences Middle Aged Neoplasm Staging Oncology Pathology Physical Sciences Prognosis Proportional Hazards Models Radiation therapy Research and Analysis Methods Statistical analysis Statistical models Surgery Survival Therapeutic applications Triple Negative Breast Neoplasms - ethnology Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - mortality Tumors
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