A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo

Guanylyl cyclase C (GCC) is a cell-surface protein that is expressed by normal intestinal epithelial cells, more than 95% of metastatic colorectal cancers (mCRC), and the majority of gastric and pancreatic cancers. Due to strict apical localization, systemically delivered GCC-targeting agents should...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0191046-e0191046
Hauptverfasser:	Gallery, Melissa, Zhang, Julie, Bradley, Daniel P, Brauer, Pamela, Cvet, Donna, Estevam, Jose, Danaee, Hadi, Greenfield, Edward, Li, Ping, Manfredi, Mark, Loke, Huay-Keng, Rabino, Claudia, Stringer, Brad, Williamson, Mark, Wyant, Tim, Yang, Johnny, Zhu, Qing, Abu-Yousif, Adnan, Veiby, O Petter
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antigens Antitumor activity Biology Biology and Life Sciences Biomarkers Cancer Cell death Cell surface Colorectal cancer Cytotoxicity Density Epithelial cells Guanylate cyclase Immunoglobulins Intestine Ligands Localization Lymphoma Medical prognosis Medicine and Health Sciences Metastases Metastasis Monoclonal antibodies Oncology Pancreas Pancreatic cancer Pharmaceutical industry Pharmacology Proteins Research and Analysis Methods Tumors Xenografts Xenotransplantation
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