Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis
Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to end...
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| creator | Wang, Hsin-Shih Tsai, Chia-Lung Chang, Pi-Yueh Chao, Angel Wu, Ren-Chin Chen, Shun-Hua Wang, Chin-Jung Yen, Chih-Feng Lee, Yun-Shien Wang, Tzu-Hao |
| description | Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression. The preoperative serum STIP1 levels of patients with endometriosis/adenomyosis were significantly higher than those of the controls. In brief, our data suggest an association between STIP1 levels and endometriosis/adenomyosis. |
| doi_str_mv | 10.1371/journal.pone.0190573 |
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This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression. The preoperative serum STIP1 levels of patients with endometriosis/adenomyosis were significantly higher than those of the controls. In brief, our data suggest an association between STIP1 levels and endometriosis/adenomyosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0190573</identifier><identifier>PMID: 29304094</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and life sciences ; Deoxyribonucleic acid ; DNA ; Endometrial cancer ; Endometriosis ; Enzyme-linked immunosorbent assay ; Gelatinase B ; Gene expression ; Gynecology ; Hospitals ; Hsp70 protein ; Hsp90 protein ; Immunohistochemistry ; Laboratories ; Matrix metalloproteinase ; Matrix metalloproteinases ; Medical research ; Medicine ; Medicine and Health Sciences ; Metalloproteinase ; Obstetrics ; Ovarian cancer ; Pathogenesis ; Protein folding ; Proteins ; Research and Analysis Methods ; Serum levels ; Stromal cells ; Tissues ; Transcription ; Womens health</subject><ispartof>PloS one, 2018-01, Vol.13 (1), p.e0190573-e0190573</ispartof><rights>2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Wang et al 2018 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-2021f5125e0b3415a8346550e58a0a0eea879252d0bab947c47b1badae7dd9973</citedby><cites>FETCH-LOGICAL-c592t-2021f5125e0b3415a8346550e58a0a0eea879252d0bab947c47b1badae7dd9973</cites><orcidid>0000-0002-1418-7684</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755831/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755831/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29304094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sachdeva, Geetanjali</contributor><creatorcontrib>Wang, Hsin-Shih</creatorcontrib><creatorcontrib>Tsai, Chia-Lung</creatorcontrib><creatorcontrib>Chang, Pi-Yueh</creatorcontrib><creatorcontrib>Chao, Angel</creatorcontrib><creatorcontrib>Wu, Ren-Chin</creatorcontrib><creatorcontrib>Chen, Shun-Hua</creatorcontrib><creatorcontrib>Wang, Chin-Jung</creatorcontrib><creatorcontrib>Yen, Chih-Feng</creatorcontrib><creatorcontrib>Lee, Yun-Shien</creatorcontrib><creatorcontrib>Wang, Tzu-Hao</creatorcontrib><title>Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression. The preoperative serum STIP1 levels of patients with endometriosis/adenomyosis were significantly higher than those of the controls. In brief, our data suggest an association between STIP1 levels and endometriosis/adenomyosis.</description><subject>Biology and life sciences</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Endometrial cancer</subject><subject>Endometriosis</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Gelatinase B</subject><subject>Gene expression</subject><subject>Gynecology</subject><subject>Hospitals</subject><subject>Hsp70 protein</subject><subject>Hsp90 protein</subject><subject>Immunohistochemistry</subject><subject>Laboratories</subject><subject>Matrix metalloproteinase</subject><subject>Matrix metalloproteinases</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metalloproteinase</subject><subject>Obstetrics</subject><subject>Ovarian cancer</subject><subject>Pathogenesis</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Research and 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phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>e0190573</spage><epage>e0190573</epage><pages>e0190573-e0190573</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression. The preoperative serum STIP1 levels of patients with endometriosis/adenomyosis were significantly higher than those of the controls. In brief, our data suggest an association between STIP1 levels and endometriosis/adenomyosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29304094</pmid><doi>10.1371/journal.pone.0190573</doi><orcidid>https://orcid.org/0000-0002-1418-7684</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and life sciences Deoxyribonucleic acid DNA Endometrial cancer Endometriosis Enzyme-linked immunosorbent assay Gelatinase B Gene expression Gynecology Hospitals Hsp70 protein Hsp90 protein Immunohistochemistry Laboratories Matrix metalloproteinase Matrix metalloproteinases Medical research Medicine Medicine and Health Sciences Metalloproteinase Obstetrics Ovarian cancer Pathogenesis Protein folding Proteins Research and Analysis Methods Serum levels Stromal cells Tissues Transcription Womens health |
| title | Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis |
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