NMR-based metabolomic profile of hypercholesterolemic human sera: Relationship with in vitro gene expression?

Hypercholesterolaemia is considered an important cause of atherosclerotic cardiovascular disease. In a previous investigation, we demonstrated that cultured hepatoma cells treated with hypercholesterolaemic sera compared with cells treated with normocholesterolaemic sera show overexpression of mRNAs...

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Veröffentlicht in:	PloS one 2020-04, Vol.15 (4), p.e0231506-e0231506
Hauptverfasser:	Grimaldi, Manuela, Palisi, Angelica, Marino, Carmen, Montoro, Paola, Capasso, Anna, Novi, Sara, Tecce, Mario Felice, D'Ursi, Anna Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acetic acid Acetone Arteriosclerosis Atherosclerosis Biology and Life Sciences Biosynthesis Cardiovascular diseases Cholesterol Citric acid Coenzyme A Data analysis Disease Enzymes Fourier transforms Gene expression Gluconeogenesis Glutamine Glycolysis Hepatoma Ketone bodies Ketones Liver cancer Medicine and Health Sciences Metabolism Metabolites Metabolomics Mitochondria NMR Nuclear magnetic resonance Pharmacy Physical Sciences Principal components analysis Pyruvic acid Research and analysis methods Statistical analysis Valine
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