A modified elliptical formula to estimate kidney collagen content in a model of chronic kidney disease
The extent of scarring or renal interstitial collagen deposition in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky, tissue biopsy. Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only do...
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| creator | Nieto, Jake A Zhu, Janice Duan, Bin Li, Jingsong Zhou, Ping Paka, Latha Yamin, Michael A Goldberg, Itzhak D Narayan, Prakash |
| description | The extent of scarring or renal interstitial collagen deposition in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky, tissue biopsy. Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only does the ellipsoid formula used today underestimate true renal size, but the calculated renal size does not inform tubulointerstitial collagen content. We used coronal kidney sections from healthy mice and mice with kidney disease to develop a new formula for estimating renal parenchymal area. While treating the kidney as an ellipse with the major axis (a) the polar distance, this technique involves extending the minor axis (b) into the renal pelvis to obtain a new minor axis, be. The calculated renal parenchymal area is remarkably similar to the true or measured area. Biochemically determined kidney collagen content revealed a strong and positive correlation with the calculated renal parenchymal area. Picrosirius red staining for tubulointerstitial collagen also correlated with calculated renal parenchymal area. The extent of renal scarring, i.e. kidney interstitial collagen content, can now be computed by making just two axial measurements which can easily be accomplished via noninvasive imaging of this organ. |
| doi_str_mv | 10.1371/journal.pone.0190815 |
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Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only does the ellipsoid formula used today underestimate true renal size, but the calculated renal size does not inform tubulointerstitial collagen content. We used coronal kidney sections from healthy mice and mice with kidney disease to develop a new formula for estimating renal parenchymal area. While treating the kidney as an ellipse with the major axis (a) the polar distance, this technique involves extending the minor axis (b) into the renal pelvis to obtain a new minor axis, be. The calculated renal parenchymal area is remarkably similar to the true or measured area. Biochemically determined kidney collagen content revealed a strong and positive correlation with the calculated renal parenchymal area. Picrosirius red staining for tubulointerstitial collagen also correlated with calculated renal parenchymal area. The extent of renal scarring, i.e. kidney interstitial collagen content, can now be computed by making just two axial measurements which can easily be accomplished via noninvasive imaging of this organ.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0190815</identifier><identifier>PMID: 29351309</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Animals ; Azo Compounds ; Biology and Life Sciences ; Biopsy ; Care and treatment ; Chronic kidney failure ; Collagen ; Collagen - metabolism ; Coloring Agents ; Development and progression ; Diagnosis ; Disease Models, Animal ; Drinking water ; Fibrosis ; Humans ; Kidney - diagnostic imaging ; Kidney - metabolism ; Kidney - pathology ; Kidney diseases ; Kidneys ; Male ; Measurement ; Medicine and Health Sciences ; Mice ; Models, Biological ; Organ Size ; Pelvis ; Physical Sciences ; Physiological aspects ; Renal Insufficiency, Chronic - diagnostic imaging ; Renal Insufficiency, Chronic - metabolism ; Renal Insufficiency, Chronic - pathology ; Research and Analysis Methods ; Scars ; Ultrasound</subject><ispartof>PloS one, 2018-01, Vol.13 (1), p.e0190815-e0190815</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Nieto et al. 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Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only does the ellipsoid formula used today underestimate true renal size, but the calculated renal size does not inform tubulointerstitial collagen content. We used coronal kidney sections from healthy mice and mice with kidney disease to develop a new formula for estimating renal parenchymal area. While treating the kidney as an ellipse with the major axis (a) the polar distance, this technique involves extending the minor axis (b) into the renal pelvis to obtain a new minor axis, be. The calculated renal parenchymal area is remarkably similar to the true or measured area. Biochemically determined kidney collagen content revealed a strong and positive correlation with the calculated renal parenchymal area. Picrosirius red staining for tubulointerstitial collagen also correlated with calculated renal parenchymal area. The extent of renal scarring, i.e. kidney interstitial collagen content, can now be computed by making just two axial measurements which can easily be accomplished via noninvasive imaging of this organ.</description><subject>Abnormalities</subject><subject>Animals</subject><subject>Azo Compounds</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Care and treatment</subject><subject>Chronic kidney failure</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Coloring Agents</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Disease Models, Animal</subject><subject>Drinking water</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Male</subject><subject>Measurement</subject><subject>Medicine and Health Sciences</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Organ Size</subject><subject>Pelvis</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Renal Insufficiency, Chronic - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nieto, Jake A</au><au>Zhu, Janice</au><au>Duan, Bin</au><au>Li, Jingsong</au><au>Zhou, Ping</au><au>Paka, Latha</au><au>Yamin, Michael A</au><au>Goldberg, Itzhak D</au><au>Narayan, Prakash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A modified elliptical formula to estimate kidney collagen content in a model of chronic kidney disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-01-19</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>e0190815</spage><epage>e0190815</epage><pages>e0190815-e0190815</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The extent of scarring or renal interstitial collagen deposition in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky, tissue biopsy. Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only does the ellipsoid formula used today underestimate true renal size, but the calculated renal size does not inform tubulointerstitial collagen content. We used coronal kidney sections from healthy mice and mice with kidney disease to develop a new formula for estimating renal parenchymal area. While treating the kidney as an ellipse with the major axis (a) the polar distance, this technique involves extending the minor axis (b) into the renal pelvis to obtain a new minor axis, be. The calculated renal parenchymal area is remarkably similar to the true or measured area. Biochemically determined kidney collagen content revealed a strong and positive correlation with the calculated renal parenchymal area. Picrosirius red staining for tubulointerstitial collagen also correlated with calculated renal parenchymal area. The extent of renal scarring, i.e. kidney interstitial collagen content, can now be computed by making just two axial measurements which can easily be accomplished via noninvasive imaging of this organ.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29351309</pmid><doi>10.1371/journal.pone.0190815</doi><tpages>e0190815</tpages><orcidid>https://orcid.org/0000-0002-7007-0245</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Animals Azo Compounds Biology and Life Sciences Biopsy Care and treatment Chronic kidney failure Collagen Collagen - metabolism Coloring Agents Development and progression Diagnosis Disease Models, Animal Drinking water Fibrosis Humans Kidney - diagnostic imaging Kidney - metabolism Kidney - pathology Kidney diseases Kidneys Male Measurement Medicine and Health Sciences Mice Models, Biological Organ Size Pelvis Physical Sciences Physiological aspects Renal Insufficiency, Chronic - diagnostic imaging Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Research and Analysis Methods Scars Ultrasound |
| title | A modified elliptical formula to estimate kidney collagen content in a model of chronic kidney disease |
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