Identification and functional analysis of SOX10 phosphorylation sites in melanoma

The transcription factor SOX10 plays an important role in vertebrate neural crest development, including the establishment and maintenance of the melanocyte lineage. SOX10 is also highly expressed in melanoma tumors, and SOX10 expression increases with tumor progression. The suppression of SOX10 in...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0190834-e0190834
Hauptverfasser:	Cronin, Julia C, Loftus, Stacie K, Baxter, Laura L, Swatkoski, Steve, Gucek, Marjan, Pavan, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biology and Life Sciences Care and treatment Cell activation Cell Line, Tumor Cellular signal transduction Chromatography, Liquid Combinatorial analysis Development and progression Functional analysis Gene expression Genetic aspects Genetic disorders Genomes Health aspects Humans Inhibitors Kinases Localization Maintenance MAP kinase Mass spectrometry Mass spectroscopy Medicine and Health Sciences MEK inhibitors Melanoma Melanoma - metabolism Mutation Nervous system Neural crest Peptides Phosphorylation Protein Processing, Post-Translational Proteins Proteomics R&D Research & development Research and Analysis Methods Scientific imaging Sox10 protein SOXE Transcription Factors - chemistry SOXE Transcription Factors - metabolism Tandem Mass Spectrometry Target recognition Transcription activation Transcription factors Tumors Vertebrates
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