A genomic biomarker-based model for cancer risk stratification of non-dysplastic Barrett's esophagus patients after extended follow up; results from Dutch surveillance cohorts

Barrett's esophagus is the only known mucosal precursor for the highly malignant esophageal adenocarcinoma. Malignant degeneration of non-dysplastic Barrett's esophagus occurs in < 0.6% per year in Dutch surveillance cohorts. Therefore, it has been proposed to increase the surveillance...

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Veröffentlicht in:	PloS one 2020-04, Vol.15 (4), p.e0231419-e0231419
Hauptverfasser:	Hoefnagel, S J M, Mostafavi, N, Timmer, M R, Lau, C T, Meijer, S L, Wang, K K, Krishnadath, K K
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adenocarcinoma Biology and Life Sciences Biomarkers c-Myc protein Cancer Cellular biology Chromosomes Clinical medicine Cloning Cytology Degeneration Deoxyribonucleic acid Developmental stages DNA Dysplasia Endoscopy ErbB-2 protein Esophageal cancer Esophagus Fluorescence Fluorescence in situ hybridization Gastroenterology Genetic diversity Health risks Health surveillance Hepatology Hybridization Intervals Medicine Medicine and Health Sciences Mucosa Myc protein p53 Protein Patients Physical Sciences Prediction models Regression analysis Research and Analysis Methods Studies Surveillance
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