PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models
To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovoltaic wireless microchip in two animal models, and refine these surgical procedures for human trials. Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted...
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| Veröffentlicht in: | PloS one 2020-04, Vol.15 (4), p.e0230713-e0230713 |
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| creator | Muqit, Mahiul M K Hubschman, Jean Pierre Picaud, Serge McCreery, Douglas B van Meurs, Jan C Hornig, Ralf Buc, Guillaume Deterre, Martin Nouvel-Jaillard, Céline Bouillet, Elodie Fovet, Claire-Maelle Hantraye, Philippe Sahel, José Martel, Joseph N Le Mer, Yannick |
| description | To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovoltaic wireless microchip in two animal models, and refine these surgical procedures for human trials.
Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central retina. The 1.5mm PRIMA chip was initially studied in feline eyes. PRIMA implant (2mm,1.5mm sizes) arrays were studied in primates. Feasibility of subretinal chip implantation was evaluated with a newly-developed surgical technique, with surgical complications and adverse events recorded.
The 1.5mm implant was placed in the central retina of 11 feline eyes, with implantation duration 43-106 days. The 1.5mm implant was correctly positioned into central macula of 11 primate eyes, with follow-up periods of minimum 6 weeks (n = 11), 2 years (n = 2), and one eye for 3 years. One primate eye underwent multi-chip 1.5mm implantation using two 1.5mm chips. The 2mm implant was delivered to 4 primate eyes. Optical coherence tomography confirmed correct surgical placement of photovoltaic arrays in the subretinal space in all 26 eyes. Intraoperative complications in primate eyes included retinal tear, macular hole, retinal detachment, and vitreous hemorrhage that resolved spontaneously. Postoperatively, there was no case of significant ocular inflammation in the 1.5mm implant group.
We report subretinal implantation of 1.5mm and 2mm photovoltaic arrays in the central retina of feline and central macula of primate eyes with a low rate of device-related complications. The in vivo PRIMA implantation technique has been developed and refined for use for a 2mm PRIMA implant in ongoing human trials. |
| doi_str_mv | 10.1371/journal.pone.0230713 |
| format | Article |
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Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central retina. The 1.5mm PRIMA chip was initially studied in feline eyes. PRIMA implant (2mm,1.5mm sizes) arrays were studied in primates. Feasibility of subretinal chip implantation was evaluated with a newly-developed surgical technique, with surgical complications and adverse events recorded.
The 1.5mm implant was placed in the central retina of 11 feline eyes, with implantation duration 43-106 days. The 1.5mm implant was correctly positioned into central macula of 11 primate eyes, with follow-up periods of minimum 6 weeks (n = 11), 2 years (n = 2), and one eye for 3 years. One primate eye underwent multi-chip 1.5mm implantation using two 1.5mm chips. The 2mm implant was delivered to 4 primate eyes. Optical coherence tomography confirmed correct surgical placement of photovoltaic arrays in the subretinal space in all 26 eyes. Intraoperative complications in primate eyes included retinal tear, macular hole, retinal detachment, and vitreous hemorrhage that resolved spontaneously. Postoperatively, there was no case of significant ocular inflammation in the 1.5mm implant group.
We report subretinal implantation of 1.5mm and 2mm photovoltaic arrays in the central retina of feline and central macula of primate eyes with a low rate of device-related complications. The in vivo PRIMA implantation technique has been developed and refined for use for a 2mm PRIMA implant in ongoing human trials.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0230713</identifier><identifier>PMID: 32267845</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal models ; Animal welfare ; Arrays ; Biocompatibility ; Biology and Life Sciences ; Biomedical research ; Complications ; Engineering and Technology ; Eye ; Eye (anatomy) ; Hemorrhage ; Human health and pathology ; Implantation ; In vivo methods and tests ; Laboratory animals ; Life Sciences ; Medical research ; Medicine and Health Sciences ; Optical Coherence Tomography ; Photovoltaics ; Primates ; Prostheses ; Retina ; Retinal detachment ; Semiconductors ; Sensory Organs ; Studies ; Surgery ; Surgical implants ; Tomography ; Transplants & implants</subject><ispartof>PloS one, 2020-04, Vol.15 (4), p.e0230713-e0230713</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Muqit et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2020 Muqit et al 2020 Muqit et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c729t-f976adfec0c1a5983a9b65c7dee044fb79aca5f3104532bf72cff419abeceba43</citedby><cites>FETCH-LOGICAL-c729t-f976adfec0c1a5983a9b65c7dee044fb79aca5f3104532bf72cff419abeceba43</cites><orcidid>0000-0002-8631-3467 ; 0000-0002-6925-3941 ; 0000-0001-5770-7451 ; 0000-0003-1161-3956 ; 0000-0001-8976-5584 ; 0000-0002-0548-5145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141693/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141693/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32267845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-02543287$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Vavvas, Demetrios G.</contributor><creatorcontrib>Muqit, Mahiul M K</creatorcontrib><creatorcontrib>Hubschman, Jean Pierre</creatorcontrib><creatorcontrib>Picaud, Serge</creatorcontrib><creatorcontrib>McCreery, Douglas B</creatorcontrib><creatorcontrib>van Meurs, Jan C</creatorcontrib><creatorcontrib>Hornig, Ralf</creatorcontrib><creatorcontrib>Buc, Guillaume</creatorcontrib><creatorcontrib>Deterre, Martin</creatorcontrib><creatorcontrib>Nouvel-Jaillard, Céline</creatorcontrib><creatorcontrib>Bouillet, Elodie</creatorcontrib><creatorcontrib>Fovet, Claire-Maelle</creatorcontrib><creatorcontrib>Hantraye, Philippe</creatorcontrib><creatorcontrib>Sahel, José</creatorcontrib><creatorcontrib>Martel, Joseph N</creatorcontrib><creatorcontrib>Le Mer, Yannick</creatorcontrib><title>PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovoltaic wireless microchip in two animal models, and refine these surgical procedures for human trials.
Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central retina. The 1.5mm PRIMA chip was initially studied in feline eyes. PRIMA implant (2mm,1.5mm sizes) arrays were studied in primates. Feasibility of subretinal chip implantation was evaluated with a newly-developed surgical technique, with surgical complications and adverse events recorded.
The 1.5mm implant was placed in the central retina of 11 feline eyes, with implantation duration 43-106 days. The 1.5mm implant was correctly positioned into central macula of 11 primate eyes, with follow-up periods of minimum 6 weeks (n = 11), 2 years (n = 2), and one eye for 3 years. One primate eye underwent multi-chip 1.5mm implantation using two 1.5mm chips. The 2mm implant was delivered to 4 primate eyes. Optical coherence tomography confirmed correct surgical placement of photovoltaic arrays in the subretinal space in all 26 eyes. Intraoperative complications in primate eyes included retinal tear, macular hole, retinal detachment, and vitreous hemorrhage that resolved spontaneously. Postoperatively, there was no case of significant ocular inflammation in the 1.5mm implant group.
We report subretinal implantation of 1.5mm and 2mm photovoltaic arrays in the central retina of feline and central macula of primate eyes with a low rate of device-related complications. The in vivo PRIMA implantation technique has been developed and refined for use for a 2mm PRIMA implant in ongoing human trials.</description><subject>Animal models</subject><subject>Animal welfare</subject><subject>Arrays</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Biomedical research</subject><subject>Complications</subject><subject>Engineering and Technology</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Hemorrhage</subject><subject>Human health and pathology</subject><subject>Implantation</subject><subject>In vivo methods and tests</subject><subject>Laboratory animals</subject><subject>Life Sciences</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Optical Coherence Tomography</subject><subject>Photovoltaics</subject><subject>Primates</subject><subject>Prostheses</subject><subject>Retina</subject><subject>Retinal detachment</subject><subject>Semiconductors</subject><subject>Sensory Organs</subject><subject>Studies</subject><subject>Surgery</subject><subject>Surgical implants</subject><subject>Tomography</subject><subject>Transplants & 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subretinal wireless photovoltaic microchip implantation in non-human primate and feline models</title><author>Muqit, Mahiul M K ; Hubschman, Jean Pierre ; Picaud, Serge ; McCreery, Douglas B ; van Meurs, Jan C ; Hornig, Ralf ; Buc, Guillaume ; Deterre, Martin ; Nouvel-Jaillard, Céline ; Bouillet, Elodie ; Fovet, Claire-Maelle ; Hantraye, Philippe ; Sahel, José ; Martel, Joseph N ; Le Mer, Yannick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c729t-f976adfec0c1a5983a9b65c7dee044fb79aca5f3104532bf72cff419abeceba43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal models</topic><topic>Animal welfare</topic><topic>Arrays</topic><topic>Biocompatibility</topic><topic>Biology and Life Sciences</topic><topic>Biomedical research</topic><topic>Complications</topic><topic>Engineering and Technology</topic><topic>Eye</topic><topic>Eye 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Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muqit, Mahiul M K</au><au>Hubschman, Jean Pierre</au><au>Picaud, Serge</au><au>McCreery, Douglas B</au><au>van Meurs, Jan C</au><au>Hornig, Ralf</au><au>Buc, Guillaume</au><au>Deterre, Martin</au><au>Nouvel-Jaillard, Céline</au><au>Bouillet, Elodie</au><au>Fovet, Claire-Maelle</au><au>Hantraye, Philippe</au><au>Sahel, José</au><au>Martel, Joseph N</au><au>Le Mer, Yannick</au><au>Vavvas, Demetrios G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-04-08</date><risdate>2020</risdate><volume>15</volume><issue>4</issue><spage>e0230713</spage><epage>e0230713</epage><pages>e0230713-e0230713</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovoltaic wireless microchip in two animal models, and refine these surgical procedures for human trials.
Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central retina. The 1.5mm PRIMA chip was initially studied in feline eyes. PRIMA implant (2mm,1.5mm sizes) arrays were studied in primates. Feasibility of subretinal chip implantation was evaluated with a newly-developed surgical technique, with surgical complications and adverse events recorded.
The 1.5mm implant was placed in the central retina of 11 feline eyes, with implantation duration 43-106 days. The 1.5mm implant was correctly positioned into central macula of 11 primate eyes, with follow-up periods of minimum 6 weeks (n = 11), 2 years (n = 2), and one eye for 3 years. One primate eye underwent multi-chip 1.5mm implantation using two 1.5mm chips. The 2mm implant was delivered to 4 primate eyes. Optical coherence tomography confirmed correct surgical placement of photovoltaic arrays in the subretinal space in all 26 eyes. Intraoperative complications in primate eyes included retinal tear, macular hole, retinal detachment, and vitreous hemorrhage that resolved spontaneously. Postoperatively, there was no case of significant ocular inflammation in the 1.5mm implant group.
We report subretinal implantation of 1.5mm and 2mm photovoltaic arrays in the central retina of feline and central macula of primate eyes with a low rate of device-related complications. The in vivo PRIMA implantation technique has been developed and refined for use for a 2mm PRIMA implant in ongoing human trials.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32267845</pmid><doi>10.1371/journal.pone.0230713</doi><tpages>e0230713</tpages><orcidid>https://orcid.org/0000-0002-8631-3467</orcidid><orcidid>https://orcid.org/0000-0002-6925-3941</orcidid><orcidid>https://orcid.org/0000-0001-5770-7451</orcidid><orcidid>https://orcid.org/0000-0003-1161-3956</orcidid><orcidid>https://orcid.org/0000-0001-8976-5584</orcidid><orcidid>https://orcid.org/0000-0002-0548-5145</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-04, Vol.15 (4), p.e0230713-e0230713 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2387634288 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animal models Animal welfare Arrays Biocompatibility Biology and Life Sciences Biomedical research Complications Engineering and Technology Eye Eye (anatomy) Hemorrhage Human health and pathology Implantation In vivo methods and tests Laboratory animals Life Sciences Medical research Medicine and Health Sciences Optical Coherence Tomography Photovoltaics Primates Prostheses Retina Retinal detachment Semiconductors Sensory Organs Studies Surgery Surgical implants Tomography Transplants & implants |
| title | PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T04%3A01%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PRIMA%20subretinal%20wireless%20photovoltaic%20microchip%20implantation%20in%20non-human%20primate%20and%20feline%20models&rft.jtitle=PloS%20one&rft.au=Muqit,%20Mahiul%20M%20K&rft.date=2020-04-08&rft.volume=15&rft.issue=4&rft.spage=e0230713&rft.epage=e0230713&rft.pages=e0230713-e0230713&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0230713&rft_dat=%3Cgale_plos_%3EA619784822%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2387634288&rft_id=info:pmid/32267845&rft_galeid=A619784822&rft_doaj_id=oai_doaj_org_article_4585a6efca254cc8b78e9a74dc7fda4a&rfr_iscdi=true |