PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions

Expanded CAG nucleotide repeats are the underlying genetic cause of at least 14 incurable diseases, including Huntington's disease (HD). The toxicity associated with many CAG repeat expansions is thought to be due to the translation of the CAG repeat to create a polyQ protein, which forms toxic...

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Veröffentlicht in:	PloS one 2020-04, Vol.15 (4), p.e0227464
Hauptverfasser:	Rudich, Paige, Watkins, Simon, Lamitina, Todd
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Amino acid sequence Animals Antisense RNA Biocompatibility Biology Biology and Life Sciences Biopolymers Canonical forms Codons Disease Diseases GABA Glutamine High definition television Huntington's disease Huntingtons disease In vivo methods and tests Medicine Medicine and Health Sciences Neurodegeneration Neurons Neurotoxicity Nucleotide sequence Nucleotides Oligomers Peptides Physiology Polyalanine Polyglutamine Polyleucine Polymers Polypeptides Proteins Ran protein Recovery (Medical) Research and Analysis Methods Ribonucleic acid RNA Toxic diseases Toxicity Translation Translations Trinucleotide repeat diseases Trinucleotide repeats γ-Aminobutyric acid
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