Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR

Chlamydia trachomatis is the most common bacterial sexually-transmitted infection and the major cause of preventable blindness worldwide. The asymptomatic nature of many infections along with uncontrolled inflammation leads to irreversible damage in the upper genital tract and the tarsal conjunctiva...

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Veröffentlicht in:	PloS one 2020-03, Vol.15 (3), p.e0230718-e0230718
Hauptverfasser:	Al-Kuhlani, Mufadhal, Lambert, Graham, Pal, Sukumar, de la Maza, Luis, Ojcius, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bacterial infections Biology and Life Sciences Blindness Chemokines Chlamydia Chlamydia infections Chlamydia trachomatis Chlamydia trachomatis - immunology Chlamydia trachomatis - physiology Complications Cytokines Dendritic cells Dentistry Diseases Epithelial cells Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - microbiology Gene Expression Regulation - immunology Gene Silencing Genetic factors Genital tract Health aspects Health risks HeLa Cells Humans Immune response Immune system Infection Infections Infertility Inflammation Interleukin 1 receptors Interleukin 8 Interleukin-8 - genetics Laboratories Medicine and Health Sciences MyD88 protein Myeloid Differentiation Factor 88 - metabolism Pain Pathogenesis Pathogenic microorganisms Pelvic pain Penicillin Plasmids Proteins Receptors Receptors, Interleukin-1 - deficiency Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - metabolism Research and analysis methods RNA, Messenger - genetics Sexually transmitted diseases STD Toll-like receptors Toll-Like Receptors - metabolism Tumor necrosis factor-TNF
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