No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression
Non-muscle invasive bladder cancer patients are at high risk for tumour recurrence and progression, hence an intensive follow-up procedure is recommended which is costly. Identification of factors that are associated with the risk of recurrence and progression may enable personalized follow-up sched...
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| description | Non-muscle invasive bladder cancer patients are at high risk for tumour recurrence and progression, hence an intensive follow-up procedure is recommended which is costly. Identification of factors that are associated with the risk of recurrence and progression may enable personalized follow-up schedules. Obesity and diabetes mellitus may be associated with a worse prognosis, but the evidence is limited and inconsistent. Our objective was to determine the associations of BMI and diabetes mellitus with risks of recurrence and progression among non-muscle invasive bladder cancer patients.
A population-based cohort of patients diagnosed with non-muscle invasive bladder cancer between 1995 and 2010 was retrospectively identified from the Netherlands Cancer Registry and invited to participate in the Nijmegen Bladder Cancer Study (n = 1,433). Average weight during adult life, height, and diabetes mellitus diagnosis were self-reported by use of a questionnaire. Clinical follow-up data were retrieved from medical files. Associations were quantified using proportional hazard analyses. For all analyses, minimal adjustment sets were selected using a Directed Acyclic Graph.
Fourteen percent of the patients indicated to be diagnosed with diabetes mellitus, and more than half was overweight (45%) or obese (9%). Compared to healthy weight, overweight and obesity were not associated with risk of recurrence (adjusted hazard ratio (HR) = 1.02; 95% confidence interval (CI): 0.86-1.22, and HR = 1.02; 95% CI: 0.76-1.38, respectively) and overall progression (HR = 1.04; 95% CI: 0.74-1.44, and HR = 1.20; 95% CI: 0.69-2.09, respectively). Also, no clear associations of diabetes mellitus with risk of recurrence (HR = 1.22; 95% CI: 0.98-1.54) and overall progression (HR = 1.16; 95% CI: 0.76-1.76) were found.
Average BMI during adult life and diabetes mellitus were not clearly associated with risk of recurrence or progression in non-muscle invasive bladder cancer. Prospective cohort studies with detailed information on BMI and diabetes mellitus before and after diagnosis are needed to confirm these findings. |
| doi_str_mv | 10.1371/journal.pone.0229384 |
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A population-based cohort of patients diagnosed with non-muscle invasive bladder cancer between 1995 and 2010 was retrospectively identified from the Netherlands Cancer Registry and invited to participate in the Nijmegen Bladder Cancer Study (n = 1,433). Average weight during adult life, height, and diabetes mellitus diagnosis were self-reported by use of a questionnaire. Clinical follow-up data were retrieved from medical files. Associations were quantified using proportional hazard analyses. For all analyses, minimal adjustment sets were selected using a Directed Acyclic Graph.
Fourteen percent of the patients indicated to be diagnosed with diabetes mellitus, and more than half was overweight (45%) or obese (9%). Compared to healthy weight, overweight and obesity were not associated with risk of recurrence (adjusted hazard ratio (HR) = 1.02; 95% confidence interval (CI): 0.86-1.22, and HR = 1.02; 95% CI: 0.76-1.38, respectively) and overall progression (HR = 1.04; 95% CI: 0.74-1.44, and HR = 1.20; 95% CI: 0.69-2.09, respectively). Also, no clear associations of diabetes mellitus with risk of recurrence (HR = 1.22; 95% CI: 0.98-1.54) and overall progression (HR = 1.16; 95% CI: 0.76-1.76) were found.
Average BMI during adult life and diabetes mellitus were not clearly associated with risk of recurrence or progression in non-muscle invasive bladder cancer. Prospective cohort studies with detailed information on BMI and diabetes mellitus before and after diagnosis are needed to confirm these findings.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0229384</identifier><identifier>PMID: 32210471</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Analysis ; Biology and Life Sciences ; Bladder ; Bladder cancer ; Body height ; Body mass index ; Body weight ; Cancer ; Cancer patients ; Cancer recurrence ; Cancer research ; Confidence intervals ; Development and progression ; Diabetes ; Diabetes mellitus ; Diagnosis ; Family medical history ; Health aspects ; Health hazards ; Health risks ; Health sciences ; Insulin resistance ; Invasiveness ; Lifestyles ; Medical diagnosis ; Medical prognosis ; Medicine and Health Sciences ; Muscles ; Obesity ; Overweight ; Patients ; Professional associations ; Prognosis ; Recurrence (Disease) ; Risk ; Schedules ; Smoking ; Studies ; Tumor necrosis factor-TNF ; Tumors ; Type 2 diabetes ; Urology ; Weight</subject><ispartof>PloS one, 2020-03, Vol.15 (3), p.e0229384-e0229384</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Evers et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Evers et al 2020 Evers et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d2f475a51adaa76309e3f0563a8f402d8ad6950ddf867da861cd86ba5998b4673</citedby><cites>FETCH-LOGICAL-c692t-d2f475a51adaa76309e3f0563a8f402d8ad6950ddf867da861cd86ba5998b4673</cites><orcidid>0000-0002-8178-2125</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094867/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094867/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32210471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Amankwah, Ernest K.</contributor><creatorcontrib>Evers, Jelle</creatorcontrib><creatorcontrib>Grotenhuis, Anne J</creatorcontrib><creatorcontrib>Aben, Katja K H</creatorcontrib><creatorcontrib>Kiemeney, Lambertus A L M</creatorcontrib><creatorcontrib>Vrieling, Alina</creatorcontrib><title>No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Non-muscle invasive bladder cancer patients are at high risk for tumour recurrence and progression, hence an intensive follow-up procedure is recommended which is costly. Identification of factors that are associated with the risk of recurrence and progression may enable personalized follow-up schedules. Obesity and diabetes mellitus may be associated with a worse prognosis, but the evidence is limited and inconsistent. Our objective was to determine the associations of BMI and diabetes mellitus with risks of recurrence and progression among non-muscle invasive bladder cancer patients.
A population-based cohort of patients diagnosed with non-muscle invasive bladder cancer between 1995 and 2010 was retrospectively identified from the Netherlands Cancer Registry and invited to participate in the Nijmegen Bladder Cancer Study (n = 1,433). Average weight during adult life, height, and diabetes mellitus diagnosis were self-reported by use of a questionnaire. Clinical follow-up data were retrieved from medical files. Associations were quantified using proportional hazard analyses. For all analyses, minimal adjustment sets were selected using a Directed Acyclic Graph.
Fourteen percent of the patients indicated to be diagnosed with diabetes mellitus, and more than half was overweight (45%) or obese (9%). Compared to healthy weight, overweight and obesity were not associated with risk of recurrence (adjusted hazard ratio (HR) = 1.02; 95% confidence interval (CI): 0.86-1.22, and HR = 1.02; 95% CI: 0.76-1.38, respectively) and overall progression (HR = 1.04; 95% CI: 0.74-1.44, and HR = 1.20; 95% CI: 0.69-2.09, respectively). Also, no clear associations of diabetes mellitus with risk of recurrence (HR = 1.22; 95% CI: 0.98-1.54) and overall progression (HR = 1.16; 95% CI: 0.76-1.76) were found.
Average BMI during adult life and diabetes mellitus were not clearly associated with risk of recurrence or progression in non-muscle invasive bladder cancer. Prospective cohort studies with detailed information on BMI and diabetes mellitus before and after diagnosis are needed to confirm these findings.</description><subject>Age</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Body height</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer recurrence</subject><subject>Cancer research</subject><subject>Confidence intervals</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Family medical history</subject><subject>Health aspects</subject><subject>Health hazards</subject><subject>Health risks</subject><subject>Health sciences</subject><subject>Insulin resistance</subject><subject>Invasiveness</subject><subject>Lifestyles</subject><subject>Medical 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K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-03-25</date><risdate>2020</risdate><volume>15</volume><issue>3</issue><spage>e0229384</spage><epage>e0229384</epage><pages>e0229384-e0229384</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Non-muscle invasive bladder cancer patients are at high risk for tumour recurrence and progression, hence an intensive follow-up procedure is recommended which is costly. Identification of factors that are associated with the risk of recurrence and progression may enable personalized follow-up schedules. Obesity and diabetes mellitus may be associated with a worse prognosis, but the evidence is limited and inconsistent. Our objective was to determine the associations of BMI and diabetes mellitus with risks of recurrence and progression among non-muscle invasive bladder cancer patients.
A population-based cohort of patients diagnosed with non-muscle invasive bladder cancer between 1995 and 2010 was retrospectively identified from the Netherlands Cancer Registry and invited to participate in the Nijmegen Bladder Cancer Study (n = 1,433). Average weight during adult life, height, and diabetes mellitus diagnosis were self-reported by use of a questionnaire. Clinical follow-up data were retrieved from medical files. Associations were quantified using proportional hazard analyses. For all analyses, minimal adjustment sets were selected using a Directed Acyclic Graph.
Fourteen percent of the patients indicated to be diagnosed with diabetes mellitus, and more than half was overweight (45%) or obese (9%). Compared to healthy weight, overweight and obesity were not associated with risk of recurrence (adjusted hazard ratio (HR) = 1.02; 95% confidence interval (CI): 0.86-1.22, and HR = 1.02; 95% CI: 0.76-1.38, respectively) and overall progression (HR = 1.04; 95% CI: 0.74-1.44, and HR = 1.20; 95% CI: 0.69-2.09, respectively). Also, no clear associations of diabetes mellitus with risk of recurrence (HR = 1.22; 95% CI: 0.98-1.54) and overall progression (HR = 1.16; 95% CI: 0.76-1.76) were found.
Average BMI during adult life and diabetes mellitus were not clearly associated with risk of recurrence or progression in non-muscle invasive bladder cancer. Prospective cohort studies with detailed information on BMI and diabetes mellitus before and after diagnosis are needed to confirm these findings.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32210471</pmid><doi>10.1371/journal.pone.0229384</doi><tpages>e0229384</tpages><orcidid>https://orcid.org/0000-0002-8178-2125</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Analysis Biology and Life Sciences Bladder Bladder cancer Body height Body mass index Body weight Cancer Cancer patients Cancer recurrence Cancer research Confidence intervals Development and progression Diabetes Diabetes mellitus Diagnosis Family medical history Health aspects Health hazards Health risks Health sciences Insulin resistance Invasiveness Lifestyles Medical diagnosis Medical prognosis Medicine and Health Sciences Muscles Obesity Overweight Patients Professional associations Prognosis Recurrence (Disease) Risk Schedules Smoking Studies Tumor necrosis factor-TNF Tumors Type 2 diabetes Urology Weight |
| title | No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
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