Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study
Delta neutrophil index (DNI) can be used as a biomarker for infection to predict patient outcomes. We aimed to investigate the relationship between DNI and clinical outcomes in trauma patients who underwent abdominal surgery. We retrospectively analyzed injured patients who underwent emergent abdomi...
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| creator | Bang, Hui-Jae Kim, Kwangmin Shim, Hongjin Kim, Seongyup Jung, Pil Young Choi, Young Un Bae, Keum Seok Kim, Ik Yong Jang, Ji Young |
| description | Delta neutrophil index (DNI) can be used as a biomarker for infection to predict patient outcomes. We aimed to investigate the relationship between DNI and clinical outcomes in trauma patients who underwent abdominal surgery.
We retrospectively analyzed injured patients who underwent emergent abdominal surgery in the regional trauma center of Wonju Severance Christian Hospital between March 2016 and May 2018. Patient characteristics, operation type, preoperative and postoperative laboratory findings, and clinical outcomes were evaluated. Logistic regression analysis was performed for risk factors associated with mortality.
Overall, 169 patients (mean age, 53.8 years; 66.3% male) were enrolled in this study, of which 19 (11.2%) died. The median injury severity score (ISS) was 12. The non-survivors had a significantly higher ISS [25(9-50) vs. 10(1-50), p |
| doi_str_mv | 10.1371/journal.pone.0230149 |
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We retrospectively analyzed injured patients who underwent emergent abdominal surgery in the regional trauma center of Wonju Severance Christian Hospital between March 2016 and May 2018. Patient characteristics, operation type, preoperative and postoperative laboratory findings, and clinical outcomes were evaluated. Logistic regression analysis was performed for risk factors associated with mortality.
Overall, 169 patients (mean age, 53.8 years; 66.3% male) were enrolled in this study, of which 19 (11.2%) died. The median injury severity score (ISS) was 12. The non-survivors had a significantly higher ISS [25(9-50) vs. 10(1-50), p<0.001] and serum lactate level (9.00±4.10 vs. 3.04±2.23, p<0.001) and more frequent shock (63.2% vs 23.3%, p<0.001) and solid organ injury (52.6% vs. 25.3%, p = 0.013) than the survivors. There were significant differences in postoperative DNI between the two groups (p<0.009 immediate post-operation, p = 0.001 on postoperative day 1 [POD1], and p = 0.013 on POD2). Logistic regression analysis showed that the independent factors associated with mortality were postoperative lactate level (odds ratio [OR] 1.926, 95% confidence interval [CI] 1.101-3.089, p = 0.007), postoperative sequential organ failure assessment score (OR 1.593, 95% CI 1.160-2.187, p = 0.004), and DNI on POD1 (OR 1.118, 95% CI 1.028-1.215, p = 0.009). The receiver operating characteristics curve demonstrated that the area under the curve of DNI on POD1 was 0.887 (cut-off level: 7.1%, sensitivity 85.7%, and specificity 84.4%).
Postoperative DNI may be a useful biomarker to predict mortality in trauma patients who underwent emergent abdominal surgery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0230149</identifier><identifier>PMID: 32203541</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Biomarkers ; Confidence intervals ; Emergency medical care ; Infection ; Injuries ; Injury analysis ; Lactic acid ; Medical research ; Medicine and Health Sciences ; Mortality ; Patient outcomes ; Patients ; Prognosis ; Regression analysis ; Risk analysis ; Risk factors ; Sepsis ; Shock ; Statistical analysis ; Studies ; Surgery ; Trauma ; Trauma centers</subject><ispartof>PloS one, 2020-03, Vol.15 (3), p.e0230149-e0230149</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Bang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Bang et al 2020 Bang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6861872036c401c980d91746ccd2f558df665ddc5cf151121f6952503fd9dd6a3</citedby><cites>FETCH-LOGICAL-c692t-6861872036c401c980d91746ccd2f558df665ddc5cf151121f6952503fd9dd6a3</cites><orcidid>0000-0003-0496-1303 ; 0000-0001-6372-4194</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089524/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089524/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32203541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ashkenazi, Itamar</contributor><creatorcontrib>Bang, Hui-Jae</creatorcontrib><creatorcontrib>Kim, Kwangmin</creatorcontrib><creatorcontrib>Shim, Hongjin</creatorcontrib><creatorcontrib>Kim, Seongyup</creatorcontrib><creatorcontrib>Jung, Pil Young</creatorcontrib><creatorcontrib>Choi, Young Un</creatorcontrib><creatorcontrib>Bae, Keum Seok</creatorcontrib><creatorcontrib>Kim, Ik Yong</creatorcontrib><creatorcontrib>Jang, Ji Young</creatorcontrib><title>Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Delta neutrophil index (DNI) can be used as a biomarker for infection to predict patient outcomes. We aimed to investigate the relationship between DNI and clinical outcomes in trauma patients who underwent abdominal surgery.
We retrospectively analyzed injured patients who underwent emergent abdominal surgery in the regional trauma center of Wonju Severance Christian Hospital between March 2016 and May 2018. Patient characteristics, operation type, preoperative and postoperative laboratory findings, and clinical outcomes were evaluated. Logistic regression analysis was performed for risk factors associated with mortality.
Overall, 169 patients (mean age, 53.8 years; 66.3% male) were enrolled in this study, of which 19 (11.2%) died. The median injury severity score (ISS) was 12. The non-survivors had a significantly higher ISS [25(9-50) vs. 10(1-50), p<0.001] and serum lactate level (9.00±4.10 vs. 3.04±2.23, p<0.001) and more frequent shock (63.2% vs 23.3%, p<0.001) and solid organ injury (52.6% vs. 25.3%, p = 0.013) than the survivors. There were significant differences in postoperative DNI between the two groups (p<0.009 immediate post-operation, p = 0.001 on postoperative day 1 [POD1], and p = 0.013 on POD2). Logistic regression analysis showed that the independent factors associated with mortality were postoperative lactate level (odds ratio [OR] 1.926, 95% confidence interval [CI] 1.101-3.089, p = 0.007), postoperative sequential organ failure assessment score (OR 1.593, 95% CI 1.160-2.187, p = 0.004), and DNI on POD1 (OR 1.118, 95% CI 1.028-1.215, p = 0.009). The receiver operating characteristics curve demonstrated that the area under the curve of DNI on POD1 was 0.887 (cut-off level: 7.1%, sensitivity 85.7%, and specificity 84.4%).
Postoperative DNI may be a useful biomarker to predict mortality in trauma patients who underwent emergent abdominal surgery.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Confidence intervals</subject><subject>Emergency medical care</subject><subject>Infection</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Lactic acid</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sepsis</subject><subject>Shock</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Trauma</subject><subject>Trauma centers</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0uP0zAQxyMEYpfCN0BgCQnBocWP2E04IFXLq9JKK_G6Wl4_WldOHGyH3d754Dg0u2rQHlAOsce_mfnPjKYoniK4QGSJ3ux8H1rhFp1v9QJiAlFZ3ytOUU3wnGFI7h-dT4pHMe4gpKRi7GFxQnA20hKdFr_fa5cEaHWfgu-21gHbKn0NjA-gC1pZmWy7AY0PSTib9vkZpCD6RoBOJKvbFMHV1oM-e4WrfAW60WEzHMSl8o3NEkHssyXs34IVkCJqIH2bszmnFYipV_vHxQMjXNRPxv-s-P7xw7ezz_Pzi0_rs9X5XLIapzmrGKqWWTmTJUSyrqCq0bJkUipsKK2UYYwqJak0iCKEkWE1xRQSo2qlmCCz4vkhbud85GMDI8ekykFJVZWZWB8I5cWOd8E2Iuy5F5b_Nfiw4SIkK53mWUKJIWVC1aQ0SNesZhoTURFMjczGWfFuzNZfNlrJ3JMg3CTo9KW1W77xv_gSVln3IObVGCD4n72OiTc2Su2caLXvD7pZrr-EGX3xD3p3dSO1EbkA2xqf88ohKF_l1hJc0xpnanEHlT-lG5tHp43N9onD64nDMF59nTaij5Gvv375f_bix5R9ecRutXBpG73rk_VtnILlAZTBxxi0uW0ygnxYlptu8GFZ-Lgs2e3Z8YBunW62g_wBhnQQOQ</recordid><startdate>20200323</startdate><enddate>20200323</enddate><creator>Bang, 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neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study</title><author>Bang, Hui-Jae ; Kim, Kwangmin ; Shim, Hongjin ; Kim, Seongyup ; Jung, Pil Young ; Choi, Young Un ; Bae, Keum Seok ; Kim, Ik Yong ; Jang, Ji Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6861872036c401c980d91746ccd2f558df665ddc5cf151121f6952503fd9dd6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Confidence intervals</topic><topic>Emergency medical care</topic><topic>Infection</topic><topic>Injuries</topic><topic>Injury analysis</topic><topic>Lactic acid</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Sepsis</topic><topic>Shock</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Trauma</topic><topic>Trauma centers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bang, Hui-Jae</creatorcontrib><creatorcontrib>Kim, Kwangmin</creatorcontrib><creatorcontrib>Shim, Hongjin</creatorcontrib><creatorcontrib>Kim, Seongyup</creatorcontrib><creatorcontrib>Jung, Pil Young</creatorcontrib><creatorcontrib>Choi, Young Un</creatorcontrib><creatorcontrib>Bae, Keum Seok</creatorcontrib><creatorcontrib>Kim, Ik Yong</creatorcontrib><creatorcontrib>Jang, Ji Young</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: 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Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bang, Hui-Jae</au><au>Kim, Kwangmin</au><au>Shim, Hongjin</au><au>Kim, Seongyup</au><au>Jung, Pil Young</au><au>Choi, Young Un</au><au>Bae, Keum Seok</au><au>Kim, Ik Yong</au><au>Jang, Ji Young</au><au>Ashkenazi, Itamar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-03-23</date><risdate>2020</risdate><volume>15</volume><issue>3</issue><spage>e0230149</spage><epage>e0230149</epage><pages>e0230149-e0230149</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Delta neutrophil index (DNI) can be used as a biomarker for infection to predict patient outcomes. We aimed to investigate the relationship between DNI and clinical outcomes in trauma patients who underwent abdominal surgery.
We retrospectively analyzed injured patients who underwent emergent abdominal surgery in the regional trauma center of Wonju Severance Christian Hospital between March 2016 and May 2018. Patient characteristics, operation type, preoperative and postoperative laboratory findings, and clinical outcomes were evaluated. Logistic regression analysis was performed for risk factors associated with mortality.
Overall, 169 patients (mean age, 53.8 years; 66.3% male) were enrolled in this study, of which 19 (11.2%) died. The median injury severity score (ISS) was 12. The non-survivors had a significantly higher ISS [25(9-50) vs. 10(1-50), p<0.001] and serum lactate level (9.00±4.10 vs. 3.04±2.23, p<0.001) and more frequent shock (63.2% vs 23.3%, p<0.001) and solid organ injury (52.6% vs. 25.3%, p = 0.013) than the survivors. There were significant differences in postoperative DNI between the two groups (p<0.009 immediate post-operation, p = 0.001 on postoperative day 1 [POD1], and p = 0.013 on POD2). Logistic regression analysis showed that the independent factors associated with mortality were postoperative lactate level (odds ratio [OR] 1.926, 95% confidence interval [CI] 1.101-3.089, p = 0.007), postoperative sequential organ failure assessment score (OR 1.593, 95% CI 1.160-2.187, p = 0.004), and DNI on POD1 (OR 1.118, 95% CI 1.028-1.215, p = 0.009). The receiver operating characteristics curve demonstrated that the area under the curve of DNI on POD1 was 0.887 (cut-off level: 7.1%, sensitivity 85.7%, and specificity 84.4%).
Postoperative DNI may be a useful biomarker to predict mortality in trauma patients who underwent emergent abdominal surgery.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32203541</pmid><doi>10.1371/journal.pone.0230149</doi><tpages>e0230149</tpages><orcidid>https://orcid.org/0000-0003-0496-1303</orcidid><orcidid>https://orcid.org/0000-0001-6372-4194</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Biology and Life Sciences Biomarkers Confidence intervals Emergency medical care Infection Injuries Injury analysis Lactic acid Medical research Medicine and Health Sciences Mortality Patient outcomes Patients Prognosis Regression analysis Risk analysis Risk factors Sepsis Shock Statistical analysis Studies Surgery Trauma Trauma centers |
| title | Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T03%3A37%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Delta%20neutrophil%20index%20for%20predicting%20mortality%20in%20trauma%20patients%20who%20underwent%20emergent%20abdominal%20surgery:%20A%20case%20controlled%20study&rft.jtitle=PloS%20one&rft.au=Bang,%20Hui-Jae&rft.date=2020-03-23&rft.volume=15&rft.issue=3&rft.spage=e0230149&rft.epage=e0230149&rft.pages=e0230149-e0230149&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0230149&rft_dat=%3Cgale_plos_%3EA618329592%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2382033884&rft_id=info:pmid/32203541&rft_galeid=A618329592&rft_doaj_id=oai_doaj_org_article_40142056ad934f1e9696e23a8325fcd9&rfr_iscdi=true |