Creatine kinase rate constant in the human heart at 7T with 1D-ISIS/2D CSI localization

Creatine Kinase (CK) reaction plays an important role in energy metabolism and estimate of its reaction rate constant in heart provides important insight into cardiac energetics. Fast saturation transfer method ([Formula: see text] nominal) to measure CK reaction rate constant (kf) was previously de...

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Veröffentlicht in:	PloS one 2020, Vol.15 (3), p.e0229933
Hauptverfasser:	Bashir, Adil, Zhang, Jianyi, Denney, Thomas S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - metabolism Adult Bandwidths Biology and Life Sciences Chemical equilibrium Computer engineering Computer simulation Creatine Creatine - metabolism Creatine kinase Creatine Kinase - isolation & purification Creatine Kinase - metabolism Energy Energy metabolism Energy Metabolism - physiology Female Heart - diagnostic imaging Heart - physiology Heart failure Heart rate Humans In vivo methods and tests Kinases Kinetics Livestock Localization Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy Male Mathematical models Medicine and Health Sciences Metabolism Metabolites Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Muscles Myocardium Myocardium - enzymology Myocardium - pathology Numerical simulations Organs Parameter estimation Phosphorus Isotopes - chemistry Physical Sciences Research and Analysis Methods Saturation Skeletal muscle Spatial discrimination Spectroscopy Spectrum analysis Swine
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