R409K mutation prevents acid-induced aggregation of human IgG4

Human immunoglobulin G isotype 4 (IgG4) antibodies are suitable for use in either the antagonist or agonist format because their low effector functions prevent target cytotoxicity or unwanted cytokine secretion. However, while manufacturing therapeutic antibodies, they are exposed to low pH during p...

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Veröffentlicht in:	PloS one 2020-03, Vol.15 (3), p.e0229027-e0229027
Hauptverfasser:	Namisaki, Hiroshi, Saito, Seiji, Hiraishi, Keiko, Haba, Tomoko, Tanaka, Yoshitaka, Yoshida, Hideaki, Iida, Shigeru, Takahashi, Nobuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Amino acids Analysis Animal models Antibodies Antigens Biocompatibility Biology and Life Sciences Biopharmaceuticals Calorimetry Chemical bonds Clinical trials Cytokines Cytotoxicity Differential scanning calorimetry Domains Format Galcanezumab Health aspects IgG antibody Immunoglobulin G Immunoglobulins Ixekizumab Kinases Medicine and Health Sciences Mutation Nivolumab Pembrolizumab pH effects Pharmaceutical sciences Physical Sciences Production management Proteins Purification R&D Receptors Research & development Research and Analysis Methods Reslizumab Stability analysis Thermal stability Toxicity
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