USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I

RIG-I plays important roles in pathogen sensing and activation of antiviral innate immune responses in response to RNA viruses. RIG-I-mediated signaling must be precisely controlled to maintain innate immune signaling homeostasis. Previous studies demonstrated that lysine 63 (K63)-linked polyubiquit...

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Veröffentlicht in:	PLoS pathogens 2020-02, Vol.16 (2), p.e1008293-e1008293
Hauptverfasser:	Tao, Xinyue, Chu, Bei, Xin, Di, Li, Lin, Sun, Qinmiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amino acids Animals Antiviral agents Antiviral drugs Biological response modifiers Biology Biology and Life Sciences Cell adhesion & migration DEAD Box Protein 58 - genetics DEAD Box Protein 58 - immunology Deoxyribonucleic acid DNA Experiments HeLa Cells Hep G2 Cells Homeostasis Humans Immune response Immunity, Innate - genetics Infections Innate immunity Interferon Interferon Type I - genetics Interferon Type I - immunology Kinases Laboratories Libraries Lysine Medical research Medicine and Health Sciences Mice Novels Phosphorylation Plasmids Proteins RAW 264.7 Cells Receptors, Immunologic Research and Analysis Methods RNA RNA viruses Signal transduction Signal Transduction - genetics Signal Transduction - immunology Signaling siRNA Ubiquitin-Specific Proteases - genetics Ubiquitin-Specific Proteases - immunology Ubiquitination - genetics Ubiquitination - immunology Viral infections Viruses Viruses - immunology Zoology
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