NRF2 negatively regulates primary ciliogenesis and hedgehog signaling

Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncoge...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS biology 2020-02, Vol.18 (2), p.e3000620
Hauptverfasser:	Liu, Pengfei, Dodson, Matthew, Fang, Deyu, Chapman, Eli, Zhang, Donna D
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Antioxidant Response Elements Biology and Life Sciences Blockage Cancer Cell growth Cell organelles Cells, Cultured Cellular signal transduction Cilia Cilia - metabolism Cilia - physiology Cilia and ciliary motion Control Crosstalk Degeneration Developmental disabilities Formation Gene Expression Gene Knockout Techniques Growth Hedgehog protein Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - metabolism Homeostasis Humans Inclusion Bodies - metabolism Metabolism Mice Microtubule-Associated Proteins - metabolism Molecular modelling Mutation NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NRF2 protein Patched-1 Receptor - genetics Patched-1 Receptor - metabolism Pharmacology Pharmacy Physiological aspects Physiology Proteins Research and Analysis Methods Sequestosome-1 Protein - genetics Sequestosome-1 Protein - metabolism Signal Transduction Signaling Toxicology Transcription factors Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!