Rickettsia felis identified in two fatal cases of acute meningoencephalitis
Rickettsia felis has recently emerged worldwide as a cause of human illness. Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly understood. We r...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2020-02, Vol.14 (2), p.e0007893-e0007893 |
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| creator | Mawuntu, Arthur H P Johar, Edison Anggraeni, Riane Feliana, Feliana Bernadus, Janno B B Safari, Dodi Yudhaputri, Frilasita A Dhenni, Rama Dewi, Yora P Kato, Cecilia Powers, Ann M Rosenberg, Ronald Soebandrio, Amin Myint, Khin S A |
| description | Rickettsia felis has recently emerged worldwide as a cause of human illness. Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly understood.
We retroactively tested cerebrospinal fluid (CSF) or sera from 64 adult patients admitted to hospital in North Sulawesi, Indonesia with acute neurological disease. Rickettsia felis DNA was identified in the CSF of two fatal cases of meningoencephalitis using multi-locus sequence typing semi-nested PCR followed by Sanger sequencing. DNA from both cases had 100% sequence homologies to the R. felis reference strain URRWXCal2 for the 17-kDa and ompB genes, and 99.91% to gltA.
The identification of R. felis in the CSF of two fatal cases of meningoencephalitis in Indonesia suggests the distribution and pathogenicity of this emerging vector-borne bacteria might be greater than generally recognized. Typically Rickettsia are susceptible to the tetracyclines and greater knowledge of R. felis endemicity in Indonesia should lead to better management of some acute neurological cases. |
| doi_str_mv | 10.1371/journal.pntd.0007893 |
| format | Article |
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We retroactively tested cerebrospinal fluid (CSF) or sera from 64 adult patients admitted to hospital in North Sulawesi, Indonesia with acute neurological disease. Rickettsia felis DNA was identified in the CSF of two fatal cases of meningoencephalitis using multi-locus sequence typing semi-nested PCR followed by Sanger sequencing. DNA from both cases had 100% sequence homologies to the R. felis reference strain URRWXCal2 for the 17-kDa and ompB genes, and 99.91% to gltA.
The identification of R. felis in the CSF of two fatal cases of meningoencephalitis in Indonesia suggests the distribution and pathogenicity of this emerging vector-borne bacteria might be greater than generally recognized. Typically Rickettsia are susceptible to the tetracyclines and greater knowledge of R. felis endemicity in Indonesia should lead to better management of some acute neurological cases.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0007893</identifier><identifier>PMID: 32069292</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Bacteria ; Bacterial Proteins - genetics ; Biology and Life Sciences ; Cerebrospinal fluid ; Deoxyribonucleic acid ; Disease control ; Disease prevention ; Diseases ; Distribution ; DNA ; DNA sequencing ; Encephalitis ; Endemism ; Ethics ; Fatal Outcome ; Fever ; Funding ; Gene sequencing ; Genes ; Genomics ; Homology ; Hospital patients ; Hospitals ; Humans ; Identification ; Male ; Medicine ; Medicine and Health Sciences ; Meningitis ; Meningoencephalitis ; Meningoencephalitis - microbiology ; Meningoencephalitis - mortality ; Molecular biology ; Multilocus Sequence Typing ; Nervous system diseases ; Neurological diseases ; Nucleotide sequence ; Pathogenicity ; Pathogens ; Patients ; PCR ; Phylogenetics ; Phylogeny ; Polymerase chain reaction ; Research and Analysis Methods ; Rickettsia felis ; Rickettsia felis - classification ; Rickettsia felis - genetics ; Rickettsia felis - isolation & purification ; Rickettsia Infections - microbiology ; Rickettsia Infections - mortality ; Sequencing ; Supervision ; Tetracyclines ; Thermal cycling ; Tropical diseases ; Vectors (Biology) ; Viral infections</subject><ispartof>PLoS neglected tropical diseases, 2020-02, Vol.14 (2), p.e0007893-e0007893</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-dfe95a4978783e9c1fab9c5fcf6ad7175f2f91f6162696deef179893f27094e93</citedby><cites>FETCH-LOGICAL-c624t-dfe95a4978783e9c1fab9c5fcf6ad7175f2f91f6162696deef179893f27094e93</cites><orcidid>0000-0002-9491-6487 ; 0000-0002-6605-6694 ; 0000-0002-2087-7331 ; 0000-0001-9782-6666 ; 0000-0003-4747-9779</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048312/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048312/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32069292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Samy, Abdallah M.</contributor><creatorcontrib>Mawuntu, Arthur H P</creatorcontrib><creatorcontrib>Johar, Edison</creatorcontrib><creatorcontrib>Anggraeni, Riane</creatorcontrib><creatorcontrib>Feliana, Feliana</creatorcontrib><creatorcontrib>Bernadus, Janno B B</creatorcontrib><creatorcontrib>Safari, Dodi</creatorcontrib><creatorcontrib>Yudhaputri, Frilasita A</creatorcontrib><creatorcontrib>Dhenni, Rama</creatorcontrib><creatorcontrib>Dewi, Yora P</creatorcontrib><creatorcontrib>Kato, Cecilia</creatorcontrib><creatorcontrib>Powers, Ann M</creatorcontrib><creatorcontrib>Rosenberg, Ronald</creatorcontrib><creatorcontrib>Soebandrio, Amin</creatorcontrib><creatorcontrib>Myint, Khin S A</creatorcontrib><title>Rickettsia felis identified in two fatal cases of acute meningoencephalitis</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Rickettsia felis has recently emerged worldwide as a cause of human illness. Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly understood.
We retroactively tested cerebrospinal fluid (CSF) or sera from 64 adult patients admitted to hospital in North Sulawesi, Indonesia with acute neurological disease. Rickettsia felis DNA was identified in the CSF of two fatal cases of meningoencephalitis using multi-locus sequence typing semi-nested PCR followed by Sanger sequencing. DNA from both cases had 100% sequence homologies to the R. felis reference strain URRWXCal2 for the 17-kDa and ompB genes, and 99.91% to gltA.
The identification of R. felis in the CSF of two fatal cases of meningoencephalitis in Indonesia suggests the distribution and pathogenicity of this emerging vector-borne bacteria might be greater than generally recognized. Typically Rickettsia are susceptible to the tetracyclines and greater knowledge of R. felis endemicity in Indonesia should lead to better management of some acute neurological cases.</description><subject>Adult</subject><subject>Bacteria</subject><subject>Bacterial Proteins - genetics</subject><subject>Biology and Life Sciences</subject><subject>Cerebrospinal fluid</subject><subject>Deoxyribonucleic acid</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Diseases</subject><subject>Distribution</subject><subject>DNA</subject><subject>DNA sequencing</subject><subject>Encephalitis</subject><subject>Endemism</subject><subject>Ethics</subject><subject>Fatal Outcome</subject><subject>Fever</subject><subject>Funding</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Genomics</subject><subject>Homology</subject><subject>Hospital patients</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Identification</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meningitis</subject><subject>Meningoencephalitis</subject><subject>Meningoencephalitis - microbiology</subject><subject>Meningoencephalitis - mortality</subject><subject>Molecular biology</subject><subject>Multilocus Sequence Typing</subject><subject>Nervous system diseases</subject><subject>Neurological diseases</subject><subject>Nucleotide sequence</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Patients</subject><subject>PCR</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Polymerase chain reaction</subject><subject>Research and Analysis Methods</subject><subject>Rickettsia felis</subject><subject>Rickettsia felis - classification</subject><subject>Rickettsia felis - genetics</subject><subject>Rickettsia felis - isolation & purification</subject><subject>Rickettsia Infections - microbiology</subject><subject>Rickettsia Infections - mortality</subject><subject>Sequencing</subject><subject>Supervision</subject><subject>Tetracyclines</subject><subject>Thermal cycling</subject><subject>Tropical diseases</subject><subject>Vectors (Biology)</subject><subject>Viral infections</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptktuKFDEQhhtR3HX1DUQbBPFmxhw7kxthWTwsLgii1yGdVGYyZpKxk1Z8e9NO7zIjSy4SKl_9VfVTTfMcoyWmAr_dpnGIOiz3sdglQkisJH3QnGNJ-YIIyh8evc-aJzlvEeKSr_Dj5owS1EkiyXnz-as3P6CU7HXrIPjceguxeOfBtj625XdqnS46tEZnyG1yrTZjgXYH0cd1gmhgv9HBF5-fNo-cDhmezfdF8_3D-29XnxY3Xz5eX13eLExHWFlYB5JrJsVKrChIg53upeHOuE5bgQV3xEnsOtyRTnYWwGEh63COCCQZSHrRvDzo7kPKavYhK0KFEIhTOhHXB8ImvVX7we_08Ecl7dW_QBrWSg_FmwCK9by3XHSMOWA9tRpJy3Bf-3DEOsmq1ru52tjvwJrqzqDDiejpT_QbtU6_lEBsRTGpAm9mgSH9HCEXtfPZQAg6QhqnvvmKVzNkV9FX_6H3TzdTa10H8NGlWtdMouqyusYJ68RELe-h6rGw8yZFcL7GTxJeHyVsQIeyySmMxaeYT0F2AM2Qch7A3ZmBkZp287ZrNe2mmnezpr04NvIu6XYZ6V8BCuCk</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Mawuntu, Arthur H P</creator><creator>Johar, Edison</creator><creator>Anggraeni, Riane</creator><creator>Feliana, Feliana</creator><creator>Bernadus, Janno B B</creator><creator>Safari, Dodi</creator><creator>Yudhaputri, Frilasita A</creator><creator>Dhenni, Rama</creator><creator>Dewi, Yora P</creator><creator>Kato, Cecilia</creator><creator>Powers, Ann M</creator><creator>Rosenberg, Ronald</creator><creator>Soebandrio, Amin</creator><creator>Myint, Khin S A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9491-6487</orcidid><orcidid>https://orcid.org/0000-0002-6605-6694</orcidid><orcidid>https://orcid.org/0000-0002-2087-7331</orcidid><orcidid>https://orcid.org/0000-0001-9782-6666</orcidid><orcidid>https://orcid.org/0000-0003-4747-9779</orcidid></search><sort><creationdate>20200201</creationdate><title>Rickettsia felis identified in two fatal cases of acute meningoencephalitis</title><author>Mawuntu, Arthur H P ; Johar, Edison ; Anggraeni, Riane ; Feliana, Feliana ; Bernadus, Janno B B ; Safari, Dodi ; Yudhaputri, Frilasita A ; Dhenni, Rama ; Dewi, Yora P ; Kato, Cecilia ; Powers, Ann M ; Rosenberg, Ronald ; Soebandrio, Amin ; Myint, Khin S A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-dfe95a4978783e9c1fab9c5fcf6ad7175f2f91f6162696deef179893f27094e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Bacteria</topic><topic>Bacterial Proteins - 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Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly understood.
We retroactively tested cerebrospinal fluid (CSF) or sera from 64 adult patients admitted to hospital in North Sulawesi, Indonesia with acute neurological disease. Rickettsia felis DNA was identified in the CSF of two fatal cases of meningoencephalitis using multi-locus sequence typing semi-nested PCR followed by Sanger sequencing. DNA from both cases had 100% sequence homologies to the R. felis reference strain URRWXCal2 for the 17-kDa and ompB genes, and 99.91% to gltA.
The identification of R. felis in the CSF of two fatal cases of meningoencephalitis in Indonesia suggests the distribution and pathogenicity of this emerging vector-borne bacteria might be greater than generally recognized. Typically Rickettsia are susceptible to the tetracyclines and greater knowledge of R. felis endemicity in Indonesia should lead to better management of some acute neurological cases.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32069292</pmid><doi>10.1371/journal.pntd.0007893</doi><orcidid>https://orcid.org/0000-0002-9491-6487</orcidid><orcidid>https://orcid.org/0000-0002-6605-6694</orcidid><orcidid>https://orcid.org/0000-0002-2087-7331</orcidid><orcidid>https://orcid.org/0000-0001-9782-6666</orcidid><orcidid>https://orcid.org/0000-0003-4747-9779</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2020-02, Vol.14 (2), p.e0007893-e0007893 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2377705339 |
| source | MEDLINE; Public Library of Science; DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Adult Bacteria Bacterial Proteins - genetics Biology and Life Sciences Cerebrospinal fluid Deoxyribonucleic acid Disease control Disease prevention Diseases Distribution DNA DNA sequencing Encephalitis Endemism Ethics Fatal Outcome Fever Funding Gene sequencing Genes Genomics Homology Hospital patients Hospitals Humans Identification Male Medicine Medicine and Health Sciences Meningitis Meningoencephalitis Meningoencephalitis - microbiology Meningoencephalitis - mortality Molecular biology Multilocus Sequence Typing Nervous system diseases Neurological diseases Nucleotide sequence Pathogenicity Pathogens Patients PCR Phylogenetics Phylogeny Polymerase chain reaction Research and Analysis Methods Rickettsia felis Rickettsia felis - classification Rickettsia felis - genetics Rickettsia felis - isolation & purification Rickettsia Infections - microbiology Rickettsia Infections - mortality Sequencing Supervision Tetracyclines Thermal cycling Tropical diseases Vectors (Biology) Viral infections |
| title | Rickettsia felis identified in two fatal cases of acute meningoencephalitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T23%3A30%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rickettsia%20felis%20identified%20in%20two%20fatal%20cases%20of%20acute%20meningoencephalitis&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Mawuntu,%20Arthur%20H%20P&rft.date=2020-02-01&rft.volume=14&rft.issue=2&rft.spage=e0007893&rft.epage=e0007893&rft.pages=e0007893-e0007893&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0007893&rft_dat=%3Cgale_plos_%3EA616524679%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2377705339&rft_id=info:pmid/32069292&rft_galeid=A616524679&rft_doaj_id=oai_doaj_org_article_4b5bd57644fe4b3da09d41b717f2df94&rfr_iscdi=true |