Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes

Meiotic recombination is essential for faithful segregation of homologous chromosomes during gametogenesis. The progression of recombination is associated with dynamic changes in meiotic chromatin structures. However, whether Sycp2, a key structural component of meiotic chromatin, is required for th...

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Veröffentlicht in:	PLoS genetics 2020-02, Vol.16 (2), p.e1008640
Hauptverfasser:	Takemoto, Kazumasa, Imai, Yukiko, Saito, Kenji, Kawasaki, Toshihiro, Carlton, Peter M, Ishiguro, Kei-Ichiro, Sakai, Noriyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetic engineering Animals Animals, Genetically Modified Biology and Life Sciences Chromatin Chromosomes Danio rerio Ethyl nitrosourea Gametogenesis Gene Knockout Techniques Genetic aspects Genetic screening Genetic testing Homologous Recombination Male Medicine and Health Sciences Meiosis Mutagenesis Mutants Mutation Prophase Research and Analysis Methods Spermatocytes Spermatocytes - metabolism Synaptonemal complex Synaptonemal Complex - genetics Synaptonemal Complex - metabolism Telomeres Yeast Zebrafish Zebrafish - physiology Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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