Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis

Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS neglected tropical diseases 2020-02, Vol.14 (2), p.e0008029
Hauptverfasser:	Dos Santos, Jéssica Cristina, Leite Quixabeira, Valéria Bernadete, Teodoro Silva, Muriel Vilela, Damen, Michelle S M A, Schraa, Kiki, Jaeger, Martin, Oosting, Marije, Keating, Samuel T, Dorta, Miriam Leandro, Alves Pinto, Sebastião, Bugalho Duarte, Fernanda, de Araújo Pereira, Ledice Inácia, Netea, Mihai G, Ribeiro-Dias, Fátima, Joosten, Leo A B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens Biology and Life Sciences Brazil - epidemiology Cells (Biology) Cohorts Cytokines Cytokines - genetics Cytokines - metabolism Defence mechanisms Female Funding Gene Expression Regulation - immunology Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic variance Genetic Variation Health aspects Hospitals Humans Immune response Immune system Immunity Immunopathogenesis Infection Infection control Infections Infectious diseases Inflammation Interleukin Interleukins Interleukins - genetics Internal medicine Isoforms Lectins, C-Type - genetics Lectins, C-Type - metabolism Leishmania Leishmania - classification Leishmaniasis Leishmaniasis, Cutaneous - epidemiology Leishmaniasis, Cutaneous - genetics Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - metabolism Male Medicine Medicine and Health Sciences Middle Aged Mucosa Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - metabolism Novels Parasites Parasitic diseases People and places Protein Isoforms Retirement benefits Software Suffering Tegumentary leishmaniasis Time Time dependence Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Tropical diseases Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!