BRAF V600E mutational load as a prognosis biomarker in malignant melanoma

Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma patients of different stages, and investigating its potential as a prognosis fa...

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Veröffentlicht in:	PloS one 2020-03, Vol.15 (3), p.e0230136-e0230136
Hauptverfasser:	Sevilla, Arrate, Morales, M Celia, Ezkurra, Pilar A, Rasero, Javier, Velasco, Verónica, Cancho-Galan, Goikoane, Sánchez-Diez, Ana, Mujika, Karmele, Penas, Cristina, Smith, Isabel, Asumendi, Aintzane, Cortés, Jesús M, Boyano, Maria Dolores, Alonso, Santos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biology Biology and Life Sciences Biomarkers Biomarkers, Tumor - genetics Comparative analysis Computer and Information Sciences Dabrafenib Deoxyribonucleic acid DNA DNA Mutational Analysis - methods Female Heterogeneity Histology Hospitals Humans Learning algorithms Machine Learning Male Medical prognosis Medical research Medicine Medicine and Health Sciences Melanoma Melanoma - genetics Melanoma - pathology Melanoma, Cutaneous Malignant Metastases Metastasis Middle Aged Mutation Neoplasm Metastasis Nevus, Pigmented Nursing Physical anthropology Physiology Prognosis Proto-Oncogene Proteins B-raf - genetics Research and Analysis Methods Skin cancer Skin Neoplasms - genetics Skin Neoplasms - pathology Vemurafenib
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