Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion
To investigate the prevalence of focal lamina cribrosa (LC) defects in patients with unilateral branch retinal vein occlusion (BRVO) and to compare ocular characteristics between eyes with and without focal LC defect and those eyes with normal-tension glaucoma (NTG). This retrospective, cross-sectio...
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| creator | Kang, Hae Min Kim, Eun Woo Choi, Jeong Hoon Koh, Hyoung Jun Lee, Sung Chul |
| description | To investigate the prevalence of focal lamina cribrosa (LC) defects in patients with unilateral branch retinal vein occlusion (BRVO) and to compare ocular characteristics between eyes with and without focal LC defect and those eyes with normal-tension glaucoma (NTG).
This retrospective, cross-sectional study included 121 patients. Thirty-nine patients had unilateral BRVO (BRVO group), 36 patients had NTG (NTG group), and 36 patients had vitreous floaters, but no other ocular diseases (control group). In addition to baseline characteristics such as age, sex, refractive errors, the ocular characteristics such as peripapillary choroidal thickness (PCT), retinal nerve fiber layer thickness, and subfoveal choroidal thickness were retrospectively analyzed.
Focal LC defects were detected in 20 eyes of 14 patients (38.9%) in the BRVO group, 24 eyes of 15 patients (41.7%) in the NTG group, and none in the control group (P |
| doi_str_mv | 10.1371/journal.pone.0230293 |
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This retrospective, cross-sectional study included 121 patients. Thirty-nine patients had unilateral BRVO (BRVO group), 36 patients had NTG (NTG group), and 36 patients had vitreous floaters, but no other ocular diseases (control group). In addition to baseline characteristics such as age, sex, refractive errors, the ocular characteristics such as peripapillary choroidal thickness (PCT), retinal nerve fiber layer thickness, and subfoveal choroidal thickness were retrospectively analyzed.
Focal LC defects were detected in 20 eyes of 14 patients (38.9%) in the BRVO group, 24 eyes of 15 patients (41.7%) in the NTG group, and none in the control group (P<0.001). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the NTG group, the mean PCT was 133.1±48.9 μm in the eyes with focal LC defects and 170.8±81.9 μm in those without (P = 0.042). The other baseline and ocular characteristics were not significantly different between the eyes with and without focal LC defects in both the BRVO group and the NTG group.
About 40% of the patients with unilateral BRVO had focal LC defect in the BRVO-affected eyes and unaffected fellow eyes, similar prevalence to the patients with NTG. The mean PCT was significantly thinner in the eyes with focal LC defect than those without in the patients with BRVO and those with NTG, suggesting possible pathophysiologic correlation between these two diseases.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0230293</identifier><identifier>PMID: 32163496</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Care and treatment ; Defects ; Diabetic retinopathy ; Diseases ; Eye ; Eye diseases ; Glaucoma ; Hospitals ; Medical imaging ; Medical research ; Medical schools ; Medicine ; Medicine and Health Sciences ; Myopia ; Occlusion ; Optic nerve ; Optics ; Patients ; Refractive errors ; Research and Analysis Methods ; Retina ; Retinal diseases ; Studies ; Thickness ; Veins & arteries</subject><ispartof>PloS one, 2020-03, Vol.15 (3), p.e0230293-e0230293</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Kang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Kang et al 2020 Kang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-aef3a1dbba52c1cc6a5ff1abcdb5276f19cc8812aa3e1ebad558a5490911a49c3</citedby><cites>FETCH-LOGICAL-c692t-aef3a1dbba52c1cc6a5ff1abcdb5276f19cc8812aa3e1ebad558a5490911a49c3</cites><orcidid>0000-0001-7675-0180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067421/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067421/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32163496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Vavvas, Demetrios G.</contributor><creatorcontrib>Kang, Hae Min</creatorcontrib><creatorcontrib>Kim, Eun Woo</creatorcontrib><creatorcontrib>Choi, Jeong Hoon</creatorcontrib><creatorcontrib>Koh, Hyoung Jun</creatorcontrib><creatorcontrib>Lee, Sung Chul</creatorcontrib><title>Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate the prevalence of focal lamina cribrosa (LC) defects in patients with unilateral branch retinal vein occlusion (BRVO) and to compare ocular characteristics between eyes with and without focal LC defect and those eyes with normal-tension glaucoma (NTG).
This retrospective, cross-sectional study included 121 patients. Thirty-nine patients had unilateral BRVO (BRVO group), 36 patients had NTG (NTG group), and 36 patients had vitreous floaters, but no other ocular diseases (control group). In addition to baseline characteristics such as age, sex, refractive errors, the ocular characteristics such as peripapillary choroidal thickness (PCT), retinal nerve fiber layer thickness, and subfoveal choroidal thickness were retrospectively analyzed.
Focal LC defects were detected in 20 eyes of 14 patients (38.9%) in the BRVO group, 24 eyes of 15 patients (41.7%) in the NTG group, and none in the control group (P<0.001). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the NTG group, the mean PCT was 133.1±48.9 μm in the eyes with focal LC defects and 170.8±81.9 μm in those without (P = 0.042). The other baseline and ocular characteristics were not significantly different between the eyes with and without focal LC defects in both the BRVO group and the NTG group.
About 40% of the patients with unilateral BRVO had focal LC defect in the BRVO-affected eyes and unaffected fellow eyes, similar prevalence to the patients with NTG. The mean PCT was significantly thinner in the eyes with focal LC defect than those without in the patients with BRVO and those with NTG, suggesting possible pathophysiologic correlation between these two diseases.</description><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Defects</subject><subject>Diabetic retinopathy</subject><subject>Diseases</subject><subject>Eye</subject><subject>Eye diseases</subject><subject>Glaucoma</subject><subject>Hospitals</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Myopia</subject><subject>Occlusion</subject><subject>Optic nerve</subject><subject>Optics</subject><subject>Patients</subject><subject>Refractive errors</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Retinal 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lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion</title><author>Kang, Hae Min ; Kim, Eun Woo ; Choi, Jeong Hoon ; Koh, Hyoung Jun ; Lee, Sung Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-aef3a1dbba52c1cc6a5ff1abcdb5276f19cc8812aa3e1ebad558a5490911a49c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Defects</topic><topic>Diabetic retinopathy</topic><topic>Diseases</topic><topic>Eye</topic><topic>Eye diseases</topic><topic>Glaucoma</topic><topic>Hospitals</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Myopia</topic><topic>Occlusion</topic><topic>Optic 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Hae Min</au><au>Kim, Eun Woo</au><au>Choi, Jeong Hoon</au><au>Koh, Hyoung Jun</au><au>Lee, Sung Chul</au><au>Vavvas, Demetrios G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-03-12</date><risdate>2020</risdate><volume>15</volume><issue>3</issue><spage>e0230293</spage><epage>e0230293</epage><pages>e0230293-e0230293</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate the prevalence of focal lamina cribrosa (LC) defects in patients with unilateral branch retinal vein occlusion (BRVO) and to compare ocular characteristics between eyes with and without focal LC defect and those eyes with normal-tension glaucoma (NTG).
This retrospective, cross-sectional study included 121 patients. Thirty-nine patients had unilateral BRVO (BRVO group), 36 patients had NTG (NTG group), and 36 patients had vitreous floaters, but no other ocular diseases (control group). In addition to baseline characteristics such as age, sex, refractive errors, the ocular characteristics such as peripapillary choroidal thickness (PCT), retinal nerve fiber layer thickness, and subfoveal choroidal thickness were retrospectively analyzed.
Focal LC defects were detected in 20 eyes of 14 patients (38.9%) in the BRVO group, 24 eyes of 15 patients (41.7%) in the NTG group, and none in the control group (P<0.001). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the NTG group, the mean PCT was 133.1±48.9 μm in the eyes with focal LC defects and 170.8±81.9 μm in those without (P = 0.042). The other baseline and ocular characteristics were not significantly different between the eyes with and without focal LC defects in both the BRVO group and the NTG group.
About 40% of the patients with unilateral BRVO had focal LC defect in the BRVO-affected eyes and unaffected fellow eyes, similar prevalence to the patients with NTG. The mean PCT was significantly thinner in the eyes with focal LC defect than those without in the patients with BRVO and those with NTG, suggesting possible pathophysiologic correlation between these two diseases.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32163496</pmid><doi>10.1371/journal.pone.0230293</doi><tpages>e0230293</tpages><orcidid>https://orcid.org/0000-0001-7675-0180</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Care and treatment Defects Diabetic retinopathy Diseases Eye Eye diseases Glaucoma Hospitals Medical imaging Medical research Medical schools Medicine Medicine and Health Sciences Myopia Occlusion Optic nerve Optics Patients Refractive errors Research and Analysis Methods Retina Retinal diseases Studies Thickness Veins & arteries |
| title | Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion |
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