Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Since hypobaric hypoxia significantly affects metabolic characteristics of intestinal flora, which plays an important role in the biotransformation of aspirin, high altitudes may influence the pharmacokinetics and therapeutic effects of aspirin in the intestines. In the present study, to test altera...

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Veröffentlicht in:	PloS one 2020-03, Vol.15 (3), p.e0230197
Hauptverfasser:	Sun, Yuemei, Zhang, Juanhong, Zhao, Anpeng, Li, Wenbin, Feng, Qiangsheng, Wang, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Altitude Analysis Ascent Aspirin Biology and Life Sciences Biotransformation Bleeding Chromatography Drugs Experiments Feces Flora Health aspects High altitude High-altitude environments Humidity Hypoxia Intestinal microflora Intestine Intestines Laboratories Liquid chromatography Low altitude Mass spectrometry Mass spectroscopy Medicine and Health Sciences Metabolism Microbiota Microbiota (Symbiotic organisms) Pharmacodynamics Pharmacokinetics Pharmacology Phenols (Class of compounds) Physical Sciences Prevention Reduction RNA rRNA 16S Salicylic acid Scientific imaging Spectroscopy
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