Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma
Despite many years of research efforts and clinical trials the prognosis of patients diagnosed with glioblastoma remains very poor. The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and ther...
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| creator | Behling, Felix Barrantes-Freer, Alonso Behnes, Carl Ludwig Stockhammer, Florian Rohde, Veit Adel-Horowski, Antonia Rodríguez-Villagra, Odir Antonio Barboza, Miguel Angel Brück, Wolfgang Lehmann, Ulrich Stadelmann, Christine Hartmann, Christian |
| description | Despite many years of research efforts and clinical trials the prognosis of patients diagnosed with glioblastoma remains very poor. The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and therapy resistance. In this retrospective analysis we assessed the prognostic value of oligodendroglial and glioma stem cell markers in 113 IDH-wildtype glioblastomas. Immunohistochemical staining for Olig2, NogoA, AQP4 and Nestin was performed in combination with sequencing of IDH1 and IDH2 as well as promotor methylation analysis of the MGMT gene. Even though differences in overall survival according to Olig2 expression were observed, univariate and multivariate survival analysis did not reveal a firm significant prognostic impact of Olig2, NogoA, AQP4 or Nestin expression. Additionally, no differences in the expression of these markers depending on clinical status, age or gender were found. The established independent prognostic factors age = 70 and methylated MGMT gene promoter were significant in the multivariate analysis. In conclusion expression of oligodendroglial and glioma stem cell markers do not have an independent prognostic effect in IDH-wildtype glioblastoma. |
| doi_str_mv | 10.1371/journal.pone.0229274 |
| format | Article |
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The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and therapy resistance. In this retrospective analysis we assessed the prognostic value of oligodendroglial and glioma stem cell markers in 113 IDH-wildtype glioblastomas. Immunohistochemical staining for Olig2, NogoA, AQP4 and Nestin was performed in combination with sequencing of IDH1 and IDH2 as well as promotor methylation analysis of the MGMT gene. Even though differences in overall survival according to Olig2 expression were observed, univariate and multivariate survival analysis did not reveal a firm significant prognostic impact of Olig2, NogoA, AQP4 or Nestin expression. Additionally, no differences in the expression of these markers depending on clinical status, age or gender were found. The established independent prognostic factors age<65, Karnofsky Performance Status> = 70 and methylated MGMT gene promoter were significant in the multivariate analysis. In conclusion expression of oligodendroglial and glioma stem cell markers do not have an independent prognostic effect in IDH-wildtype glioblastoma.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0229274</identifier><identifier>PMID: 32160197</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antineoplastic agents ; Aquaporin 4 ; Aquaporins ; Authorship ; Biology and Life Sciences ; Biopsy ; Brain cancer ; Clinical trials ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Gene expression ; Genes ; Glioblastoma ; Glioblastomas ; Glioma ; Glioma cells ; Gliomas ; Hospitals ; Immunohistochemistry ; Managers ; Markers ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Methylation ; Multivariate analysis ; Mutation ; Nervous system ; Nestin ; Neuropathology ; Neurosurgery ; Olig2 protein ; Pathology ; Patient outcomes ; Patients ; Physical Sciences ; Prognosis ; Research and Analysis Methods ; Stem cell transplantation ; Stem cells ; Survival ; Tumors</subject><ispartof>PloS one, 2020-03, Vol.15 (3), p.e0229274-e0229274</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Behling et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Behling et al 2020 Behling et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ed47221832f25d0c72538ef195a546a19bc7113945ff2da96cdb5538232595dc3</citedby><cites>FETCH-LOGICAL-c692t-ed47221832f25d0c72538ef195a546a19bc7113945ff2da96cdb5538232595dc3</cites><orcidid>0000-0002-1083-1276</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065747/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065747/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32160197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hjelmeland, Anita B.</contributor><creatorcontrib>Behling, Felix</creatorcontrib><creatorcontrib>Barrantes-Freer, Alonso</creatorcontrib><creatorcontrib>Behnes, Carl Ludwig</creatorcontrib><creatorcontrib>Stockhammer, Florian</creatorcontrib><creatorcontrib>Rohde, Veit</creatorcontrib><creatorcontrib>Adel-Horowski, Antonia</creatorcontrib><creatorcontrib>Rodríguez-Villagra, Odir Antonio</creatorcontrib><creatorcontrib>Barboza, Miguel Angel</creatorcontrib><creatorcontrib>Brück, Wolfgang</creatorcontrib><creatorcontrib>Lehmann, Ulrich</creatorcontrib><creatorcontrib>Stadelmann, Christine</creatorcontrib><creatorcontrib>Hartmann, Christian</creatorcontrib><title>Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite many years of research efforts and clinical trials the prognosis of patients diagnosed with glioblastoma remains very poor. The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and therapy resistance. In this retrospective analysis we assessed the prognostic value of oligodendroglial and glioma stem cell markers in 113 IDH-wildtype glioblastomas. Immunohistochemical staining for Olig2, NogoA, AQP4 and Nestin was performed in combination with sequencing of IDH1 and IDH2 as well as promotor methylation analysis of the MGMT gene. Even though differences in overall survival according to Olig2 expression were observed, univariate and multivariate survival analysis did not reveal a firm significant prognostic impact of Olig2, NogoA, AQP4 or Nestin expression. Additionally, no differences in the expression of these markers depending on clinical status, age or gender were found. The established independent prognostic factors age<65, Karnofsky Performance Status> = 70 and methylated MGMT gene promoter were significant in the multivariate analysis. In conclusion expression of oligodendroglial and glioma stem cell markers do not have an independent prognostic effect in IDH-wildtype glioblastoma.</description><subject>Analysis</subject><subject>Antineoplastic agents</subject><subject>Aquaporin 4</subject><subject>Aquaporins</subject><subject>Authorship</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Brain cancer</subject><subject>Clinical trials</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Glioblastoma</subject><subject>Glioblastomas</subject><subject>Glioma</subject><subject>Glioma cells</subject><subject>Gliomas</subject><subject>Hospitals</subject><subject>Immunohistochemistry</subject><subject>Managers</subject><subject>Markers</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Methylation</subject><subject>Multivariate analysis</subject><subject>Mutation</subject><subject>Nervous system</subject><subject>Nestin</subject><subject>Neuropathology</subject><subject>Neurosurgery</subject><subject>Olig2 protein</subject><subject>Pathology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prognosis</subject><subject>Research and Analysis Methods</subject><subject>Stem cell transplantation</subject><subject>Stem 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of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma</title><author>Behling, Felix ; Barrantes-Freer, Alonso ; Behnes, Carl Ludwig ; Stockhammer, Florian ; Rohde, Veit ; Adel-Horowski, Antonia ; Rodríguez-Villagra, Odir Antonio ; Barboza, Miguel Angel ; Brück, Wolfgang ; Lehmann, Ulrich ; Stadelmann, Christine ; Hartmann, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ed47221832f25d0c72538ef195a546a19bc7113945ff2da96cdb5538232595dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Antineoplastic agents</topic><topic>Aquaporin 4</topic><topic>Aquaporins</topic><topic>Authorship</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Brain cancer</topic><topic>Clinical trials</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA 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One</addtitle><date>2020-03-11</date><risdate>2020</risdate><volume>15</volume><issue>3</issue><spage>e0229274</spage><epage>e0229274</epage><pages>e0229274-e0229274</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Despite many years of research efforts and clinical trials the prognosis of patients diagnosed with glioblastoma remains very poor. The oligodendrocyte transcription factor 2 (Olig2) was identified as a marker for glioma stem cells, which are believed to be responsible for glioma recurrence and therapy resistance. In this retrospective analysis we assessed the prognostic value of oligodendroglial and glioma stem cell markers in 113 IDH-wildtype glioblastomas. Immunohistochemical staining for Olig2, NogoA, AQP4 and Nestin was performed in combination with sequencing of IDH1 and IDH2 as well as promotor methylation analysis of the MGMT gene. Even though differences in overall survival according to Olig2 expression were observed, univariate and multivariate survival analysis did not reveal a firm significant prognostic impact of Olig2, NogoA, AQP4 or Nestin expression. Additionally, no differences in the expression of these markers depending on clinical status, age or gender were found. The established independent prognostic factors age<65, Karnofsky Performance Status> = 70 and methylated MGMT gene promoter were significant in the multivariate analysis. In conclusion expression of oligodendroglial and glioma stem cell markers do not have an independent prognostic effect in IDH-wildtype glioblastoma.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32160197</pmid><doi>10.1371/journal.pone.0229274</doi><tpages>e0229274</tpages><orcidid>https://orcid.org/0000-0002-1083-1276</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2020-03, Vol.15 (3), p.e0229274-e0229274 |
| issn | 1932-6203 1932-6203 |
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| source | Public Library of Science (PLoS) Journals Open Access; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Analysis Antineoplastic agents Aquaporin 4 Aquaporins Authorship Biology and Life Sciences Biopsy Brain cancer Clinical trials Deoxyribonucleic acid DNA DNA methylation Gene expression Genes Glioblastoma Glioblastomas Glioma Glioma cells Gliomas Hospitals Immunohistochemistry Managers Markers Medical prognosis Medical research Medicine and Health Sciences Methylation Multivariate analysis Mutation Nervous system Nestin Neuropathology Neurosurgery Olig2 protein Pathology Patient outcomes Patients Physical Sciences Prognosis Research and Analysis Methods Stem cell transplantation Stem cells Survival Tumors |
| title | Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T21%3A10%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20Olig2,%20Nestin,%20NogoA%20and%20AQP4%20have%20no%20impact%20on%20overall%20survival%20in%20IDH-wildtype%20glioblastoma&rft.jtitle=PloS%20one&rft.au=Behling,%20Felix&rft.date=2020-03-11&rft.volume=15&rft.issue=3&rft.spage=e0229274&rft.epage=e0229274&rft.pages=e0229274-e0229274&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0229274&rft_dat=%3Cgale_plos_%3EA617101197%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2376207217&rft_id=info:pmid/32160197&rft_galeid=A617101197&rft_doaj_id=oai_doaj_org_article_50fde65f0bb440d99631f856de0e0b63&rfr_iscdi=true |