Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells

Our earlier studies proved that RIPK3-mediated necroptosis might be an important mode of renal tubular cell death in rats with chronic renal injury and the necroptotic cell death can be triggered by tumor necrosis factor-α (TNF-α) in vitro, but the triggering role of angiotensin II (AngII), which ex...

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Veröffentlicht in:	PloS one 2020-03, Vol.15 (3), p.e0228385-e0228385
Hauptverfasser:	Zhu, Yongjun, Cui, Hongwang, Lv, Jie, Li, Guojun, Li, Xiaoyan, Ye, Feng, Zhong, Liangbao
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensins Apoptosis Atrophy Biochemistry Biology and Life Sciences Biotechnology industries Cell death Disruption Epithelial cells FasL protein Fibrosis Gene expression Kidney diseases Kidneys Kinases Laboratory animals Medicine and Health Sciences Morphology Mortality Necroptosis Necrosis Nephrology Orthopedics Proteins Research and Analysis Methods Signal transduction Signaling Tumor necrosis factor Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors
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