Effects of diuretic administration on outcomes of extracorporeal shockwave lithotripsy: A systematic review and meta-analysis
The present systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted for investigating the effect of diuretics on the outcomes of shockwave lithotripsy (SWL) for the treatment of urinary stones. We performed searches of PubMed, Web of science, Embase, EBSCO, and Cochr...
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| description | The present systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted for investigating the effect of diuretics on the outcomes of shockwave lithotripsy (SWL) for the treatment of urinary stones. We performed searches of PubMed, Web of science, Embase, EBSCO, and Cochrane library databases from inception to November 2019. RCTs were selected for assessing the effects of diuretics on fragmentation and clearance of urinary stones. The search strategy and study selection process were performed in accordance with the PRISMA guidelines. Four RCTs were included in the meta-analysis. Overall, intervention groups experienced significant improvements in fragmentation compared with the control groups (risk ratio [RR] = 1.14, 95% confidence interval [CI] = 1.05-1.03, P = 0.02). However, stone clearance did not significantly differ between the intervention and control groups (RR = 1.23, 95% CI = 0.97-1.56, P = 0.08). The total numbers of shocks and sessions required were significantly reduced by the use of diuretics. Diuretics significantly enhance stone fragmentation for patients undergoing SWL. However, the improvement in stone clearance appears to be insignificant. |
| doi_str_mv | 10.1371/journal.pone.0230059 |
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We performed searches of PubMed, Web of science, Embase, EBSCO, and Cochrane library databases from inception to November 2019. RCTs were selected for assessing the effects of diuretics on fragmentation and clearance of urinary stones. The search strategy and study selection process were performed in accordance with the PRISMA guidelines. Four RCTs were included in the meta-analysis. Overall, intervention groups experienced significant improvements in fragmentation compared with the control groups (risk ratio [RR] = 1.14, 95% confidence interval [CI] = 1.05-1.03, P = 0.02). However, stone clearance did not significantly differ between the intervention and control groups (RR = 1.23, 95% CI = 0.97-1.56, P = 0.08). The total numbers of shocks and sessions required were significantly reduced by the use of diuretics. Diuretics significantly enhance stone fragmentation for patients undergoing SWL. However, the improvement in stone clearance appears to be insignificant.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0230059</identifier><identifier>PMID: 32134993</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Clinical trials ; Confidence intervals ; Diuretics ; Drug dosages ; Drug therapy ; Extracorporeal shockwave lithotripsy ; Fragmentation ; Lithotripsy ; Medicine and Health Sciences ; Meta-analysis ; Patients ; Physical Sciences ; Quality ; Research and Analysis Methods ; Risk management ; Shock waves ; Stone ; Studies ; Systematic review ; Urinary stones ; Urogenital system ; Urology</subject><ispartof>PloS one, 2020-03, Vol.15 (3), p.e0230059-e0230059</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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However, the improvement in stone clearance appears to be insignificant.</description><subject>Analysis</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Diuretics</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Extracorporeal shockwave lithotripsy</subject><subject>Fragmentation</subject><subject>Lithotripsy</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Quality</subject><subject>Research and Analysis Methods</subject><subject>Risk management</subject><subject>Shock waves</subject><subject>Stone</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Urinary stones</subject><subject>Urogenital 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhenghao</au><au>Bai, Yunjin</au><au>Wang, Jia</au><au>Bilotta, Federico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of diuretic administration on outcomes of extracorporeal shockwave lithotripsy: A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-03-05</date><risdate>2020</risdate><volume>15</volume><issue>3</issue><spage>e0230059</spage><epage>e0230059</epage><pages>e0230059-e0230059</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The present systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted for investigating the effect of diuretics on the outcomes of shockwave lithotripsy (SWL) for the treatment of urinary stones. We performed searches of PubMed, Web of science, Embase, EBSCO, and Cochrane library databases from inception to November 2019. RCTs were selected for assessing the effects of diuretics on fragmentation and clearance of urinary stones. The search strategy and study selection process were performed in accordance with the PRISMA guidelines. Four RCTs were included in the meta-analysis. Overall, intervention groups experienced significant improvements in fragmentation compared with the control groups (risk ratio [RR] = 1.14, 95% confidence interval [CI] = 1.05-1.03, P = 0.02). However, stone clearance did not significantly differ between the intervention and control groups (RR = 1.23, 95% CI = 0.97-1.56, P = 0.08). The total numbers of shocks and sessions required were significantly reduced by the use of diuretics. Diuretics significantly enhance stone fragmentation for patients undergoing SWL. However, the improvement in stone clearance appears to be insignificant.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32134993</pmid><doi>10.1371/journal.pone.0230059</doi><orcidid>https://orcid.org/0000-0001-9674-5266</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Clinical trials Confidence intervals Diuretics Drug dosages Drug therapy Extracorporeal shockwave lithotripsy Fragmentation Lithotripsy Medicine and Health Sciences Meta-analysis Patients Physical Sciences Quality Research and Analysis Methods Risk management Shock waves Stone Studies Systematic review Urinary stones Urogenital system Urology |
| title | Effects of diuretic administration on outcomes of extracorporeal shockwave lithotripsy: A systematic review and meta-analysis |
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