Aquaporin locus (12q13.12) might contribute to susceptibility of temporomandibular joint disorder associated with periodontitis
Aquaporins (AQPs) are membrane channels that provide for transport of water and other small molecules across the lipid bilayer of cells. Their function is essential for physiologic processes such as cell volume regulation, chondrocyte hypertrophy during appendicular skeletal growth, water reabsorpti...
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| description | Aquaporins (AQPs) are membrane channels that provide for transport of water and other small molecules across the lipid bilayer of cells. Their function is essential for physiologic processes such as cell volume regulation, chondrocyte hypertrophy during appendicular skeletal growth, water reabsorption in the kidney tubules, and water excretion by the salivary glands. The ten AQP isoforms show tissue specificity and are involved in different pathologies and inflammatory diseases. This study addresses the hypothesis that arthritis, periodontitis, and temporomandibular joint disorders (TMDs) can be influenced by variation in the AQP genes at 12q13.12 locus. Salivary samples of 688 individuals were obtained from the Dental Registry and DNA Repository project at the University of Pittsburgh. Ten polymorphisms in four AQP genes (AQP1, 2, 5, and 6) were genotyped and correlated to disease status as reported by patients. Associations were found between the single nucleotide polymorphism (SNP) rs467323 in AQP2 and TMD in both genotypic (p = 0.03) and recessive (p = 0.02) models, and between rs1996315 in AQP6 and periodontitis (p = 0.05). Combined analysis of TMD and periodontitis showed an association with rs3741559 in AQP2 (p = 0.02). When conducting haplotype analysis of rs467323 and rs10875989 in AQP2, the haplotype CT showed an association with the TMD phenotype (p = 0.007). Our results suggest that the aquaporin locus at 12q13.12 may contribute to the pathogenesis of inflammatory conditions such as periodontitis and TMD. Thus, oral and skeletal health are correlated and potential susceptibility screening strategies may be developed. |
| doi_str_mv | 10.1371/journal.pone.0229245 |
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Their function is essential for physiologic processes such as cell volume regulation, chondrocyte hypertrophy during appendicular skeletal growth, water reabsorption in the kidney tubules, and water excretion by the salivary glands. The ten AQP isoforms show tissue specificity and are involved in different pathologies and inflammatory diseases. This study addresses the hypothesis that arthritis, periodontitis, and temporomandibular joint disorders (TMDs) can be influenced by variation in the AQP genes at 12q13.12 locus. Salivary samples of 688 individuals were obtained from the Dental Registry and DNA Repository project at the University of Pittsburgh. Ten polymorphisms in four AQP genes (AQP1, 2, 5, and 6) were genotyped and correlated to disease status as reported by patients. Associations were found between the single nucleotide polymorphism (SNP) rs467323 in AQP2 and TMD in both genotypic (p = 0.03) and recessive (p = 0.02) models, and between rs1996315 in AQP6 and periodontitis (p = 0.05). Combined analysis of TMD and periodontitis showed an association with rs3741559 in AQP2 (p = 0.02). When conducting haplotype analysis of rs467323 and rs10875989 in AQP2, the haplotype CT showed an association with the TMD phenotype (p = 0.007). Our results suggest that the aquaporin locus at 12q13.12 may contribute to the pathogenesis of inflammatory conditions such as periodontitis and TMD. Thus, oral and skeletal health are correlated and potential susceptibility screening strategies may be developed.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0229245</identifier><identifier>PMID: 32130259</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; Aquaporin 1 ; Aquaporin 2 ; Aquaporin 6 ; Aquaporins ; Aquaporins - genetics ; Arthritis ; Biology ; Biology and Life Sciences ; Cell adhesion & migration ; Cell size ; Chondrocytes ; Chromosome 12 ; Dentistry ; Deoxyribonucleic acid ; Disease ; Disease susceptibility ; Diseases ; DNA ; Female ; Genes ; Genetic Loci - genetics ; Genetic polymorphisms ; Genetic Predisposition to Disease - genetics ; Genotype & phenotype ; Gum disease ; Haplotypes ; Humans ; Hypertrophy ; Inflammation ; Inflammatory diseases ; Isoforms ; Joints (anatomy) ; Lipid bilayers ; Lipids ; Loci ; Male ; Medical research ; Medicine and Health Sciences ; Membrane channels ; Middle Aged ; Nucleotides ; Pathogenesis ; Pediatrics ; Periodontitis ; Periodontitis - complications ; Phenotypes ; Polymorphism ; Polymorphism, Single Nucleotide ; Reabsorption ; Research and Analysis Methods ; Rheumatoid arthritis ; Salivary gland ; Salivary glands ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Temporomandibular joint ; Temporomandibular Joint Disorders - complications ; Temporomandibular Joint Disorders - genetics ; Tubules ; Young Adult</subject><ispartof>PloS one, 2020-03, Vol.15 (3), p.e0229245</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Bezamat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Bezamat et al 2020 Bezamat et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-9d9fbf7b7cf23f35fe8769bb16ab096e857b598d5eef058569cc7cdacea8c2233</citedby><cites>FETCH-LOGICAL-c593t-9d9fbf7b7cf23f35fe8769bb16ab096e857b598d5eef058569cc7cdacea8c2233</cites><orcidid>0000-0003-0523-3359</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055872/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055872/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32130259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bezamat, Mariana</creatorcontrib><creatorcontrib>Cunha, Emanuelle J</creatorcontrib><creatorcontrib>Modesto, Adriana M</creatorcontrib><creatorcontrib>Vieira, Alexandre R</creatorcontrib><creatorcontrib>Taboas, Juan M</creatorcontrib><title>Aquaporin locus (12q13.12) might contribute to susceptibility of temporomandibular joint disorder associated with periodontitis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Aquaporins (AQPs) are membrane channels that provide for transport of water and other small molecules across the lipid bilayer of cells. Their function is essential for physiologic processes such as cell volume regulation, chondrocyte hypertrophy during appendicular skeletal growth, water reabsorption in the kidney tubules, and water excretion by the salivary glands. The ten AQP isoforms show tissue specificity and are involved in different pathologies and inflammatory diseases. This study addresses the hypothesis that arthritis, periodontitis, and temporomandibular joint disorders (TMDs) can be influenced by variation in the AQP genes at 12q13.12 locus. Salivary samples of 688 individuals were obtained from the Dental Registry and DNA Repository project at the University of Pittsburgh. Ten polymorphisms in four AQP genes (AQP1, 2, 5, and 6) were genotyped and correlated to disease status as reported by patients. Associations were found between the single nucleotide polymorphism (SNP) rs467323 in AQP2 and TMD in both genotypic (p = 0.03) and recessive (p = 0.02) models, and between rs1996315 in AQP6 and periodontitis (p = 0.05). Combined analysis of TMD and periodontitis showed an association with rs3741559 in AQP2 (p = 0.02). When conducting haplotype analysis of rs467323 and rs10875989 in AQP2, the haplotype CT showed an association with the TMD phenotype (p = 0.007). Our results suggest that the aquaporin locus at 12q13.12 may contribute to the pathogenesis of inflammatory conditions such as periodontitis and TMD. Thus, oral and skeletal health are correlated and potential susceptibility screening strategies may be developed.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Aquaporin 1</subject><subject>Aquaporin 2</subject><subject>Aquaporin 6</subject><subject>Aquaporins</subject><subject>Aquaporins - genetics</subject><subject>Arthritis</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Cell adhesion & migration</subject><subject>Cell size</subject><subject>Chondrocytes</subject><subject>Chromosome 12</subject><subject>Dentistry</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>Disease susceptibility</subject><subject>Diseases</subject><subject>DNA</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Loci - genetics</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype & phenotype</subject><subject>Gum disease</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Isoforms</subject><subject>Joints (anatomy)</subject><subject>Lipid bilayers</subject><subject>Lipids</subject><subject>Loci</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Membrane channels</subject><subject>Middle Aged</subject><subject>Nucleotides</subject><subject>Pathogenesis</subject><subject>Pediatrics</subject><subject>Periodontitis</subject><subject>Periodontitis - complications</subject><subject>Phenotypes</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Reabsorption</subject><subject>Research and Analysis Methods</subject><subject>Rheumatoid arthritis</subject><subject>Salivary gland</subject><subject>Salivary glands</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Temporomandibular joint</subject><subject>Temporomandibular Joint Disorders - complications</subject><subject>Temporomandibular Joint Disorders - genetics</subject><subject>Tubules</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1vEzEUXCEQLYF_gMASl3JI8EfstS9IUVWgUiUucLa8_kgc7a43treoJ_56vWRbNajywdbzzLz3RlNV7xFcIVKjL_swxl61qyH0dgUxFnhNX1TnSBC8ZBiSl0_eZ9WblPYQUsIZe12dEYwIxFScV383h1ENIfoetEGPCVwgfEBkhfBn0PntLgMd-hx9M2YLcgBpTNoO2Te-9fkOBAey7Qo_dKo3BdWqCPbB9xkYn0I0NgKVUtBeZWvAH593YLDRB1NUffbpbfXKqTbZd_O9qH5_u_p1-WN58_P79eXmZqmpIHkpjHCNq5taO0wcoc7ymommQUw1UDDLad1QwQ211kHKKRNa19oobRXXGBOyqD4edYc2JDl7lyQuTlKERc0K4vqIMEHt5RB9p-KdDMrLf4UQt1LF7HVrJSdMkdJujSlZc4MaRzhkzCFRyhDhovV17jY2nTXaFgtVeyJ6-tP7ndyGW1lDSnk9CVzMAjEcRpuy7Hwxvm1Vb8N4nJszKPgE_fQf9PntZtRWlQV870LpqydRuWGI4eJZSceiWj2DKsfYzpcgWOdL_YSwPhJ0DClF6x53RFBOMX0YRk4xlXNMC-3DU38eSQ-5JPfUDuZ7</recordid><startdate>20200304</startdate><enddate>20200304</enddate><creator>Bezamat, Mariana</creator><creator>Cunha, Emanuelle J</creator><creator>Modesto, Adriana M</creator><creator>Vieira, Alexandre R</creator><creator>Taboas, Juan M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0523-3359</orcidid></search><sort><creationdate>20200304</creationdate><title>Aquaporin locus (12q13.12) might contribute to susceptibility of temporomandibular joint disorder associated with periodontitis</title><author>Bezamat, Mariana ; Cunha, Emanuelle J ; Modesto, Adriana M ; Vieira, Alexandre R ; Taboas, Juan M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-9d9fbf7b7cf23f35fe8769bb16ab096e857b598d5eef058569cc7cdacea8c2233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Aquaporin 1</topic><topic>Aquaporin 2</topic><topic>Aquaporin 6</topic><topic>Aquaporins</topic><topic>Aquaporins - genetics</topic><topic>Arthritis</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Cell adhesion & migration</topic><topic>Cell size</topic><topic>Chondrocytes</topic><topic>Chromosome 12</topic><topic>Dentistry</topic><topic>Deoxyribonucleic acid</topic><topic>Disease</topic><topic>Disease susceptibility</topic><topic>Diseases</topic><topic>DNA</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Loci - genetics</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype & phenotype</topic><topic>Gum disease</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Isoforms</topic><topic>Joints (anatomy)</topic><topic>Lipid bilayers</topic><topic>Lipids</topic><topic>Loci</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Membrane channels</topic><topic>Middle Aged</topic><topic>Nucleotides</topic><topic>Pathogenesis</topic><topic>Pediatrics</topic><topic>Periodontitis</topic><topic>Periodontitis - complications</topic><topic>Phenotypes</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Reabsorption</topic><topic>Research and Analysis Methods</topic><topic>Rheumatoid arthritis</topic><topic>Salivary gland</topic><topic>Salivary glands</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Temporomandibular joint</topic><topic>Temporomandibular Joint Disorders - complications</topic><topic>Temporomandibular Joint Disorders - genetics</topic><topic>Tubules</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bezamat, Mariana</creatorcontrib><creatorcontrib>Cunha, Emanuelle J</creatorcontrib><creatorcontrib>Modesto, Adriana M</creatorcontrib><creatorcontrib>Vieira, Alexandre R</creatorcontrib><creatorcontrib>Taboas, Juan M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bezamat, Mariana</au><au>Cunha, Emanuelle J</au><au>Modesto, Adriana M</au><au>Vieira, Alexandre R</au><au>Taboas, Juan M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aquaporin locus (12q13.12) might contribute to susceptibility of temporomandibular joint disorder associated with periodontitis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-03-04</date><risdate>2020</risdate><volume>15</volume><issue>3</issue><spage>e0229245</spage><pages>e0229245-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Aquaporins (AQPs) are membrane channels that provide for transport of water and other small molecules across the lipid bilayer of cells. Their function is essential for physiologic processes such as cell volume regulation, chondrocyte hypertrophy during appendicular skeletal growth, water reabsorption in the kidney tubules, and water excretion by the salivary glands. The ten AQP isoforms show tissue specificity and are involved in different pathologies and inflammatory diseases. This study addresses the hypothesis that arthritis, periodontitis, and temporomandibular joint disorders (TMDs) can be influenced by variation in the AQP genes at 12q13.12 locus. Salivary samples of 688 individuals were obtained from the Dental Registry and DNA Repository project at the University of Pittsburgh. Ten polymorphisms in four AQP genes (AQP1, 2, 5, and 6) were genotyped and correlated to disease status as reported by patients. Associations were found between the single nucleotide polymorphism (SNP) rs467323 in AQP2 and TMD in both genotypic (p = 0.03) and recessive (p = 0.02) models, and between rs1996315 in AQP6 and periodontitis (p = 0.05). Combined analysis of TMD and periodontitis showed an association with rs3741559 in AQP2 (p = 0.02). When conducting haplotype analysis of rs467323 and rs10875989 in AQP2, the haplotype CT showed an association with the TMD phenotype (p = 0.007). Our results suggest that the aquaporin locus at 12q13.12 may contribute to the pathogenesis of inflammatory conditions such as periodontitis and TMD. Thus, oral and skeletal health are correlated and potential susceptibility screening strategies may be developed.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32130259</pmid><doi>10.1371/journal.pone.0229245</doi><orcidid>https://orcid.org/0000-0003-0523-3359</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Aged, 80 and over Analysis Aquaporin 1 Aquaporin 2 Aquaporin 6 Aquaporins Aquaporins - genetics Arthritis Biology Biology and Life Sciences Cell adhesion & migration Cell size Chondrocytes Chromosome 12 Dentistry Deoxyribonucleic acid Disease Disease susceptibility Diseases DNA Female Genes Genetic Loci - genetics Genetic polymorphisms Genetic Predisposition to Disease - genetics Genotype & phenotype Gum disease Haplotypes Humans Hypertrophy Inflammation Inflammatory diseases Isoforms Joints (anatomy) Lipid bilayers Lipids Loci Male Medical research Medicine and Health Sciences Membrane channels Middle Aged Nucleotides Pathogenesis Pediatrics Periodontitis Periodontitis - complications Phenotypes Polymorphism Polymorphism, Single Nucleotide Reabsorption Research and Analysis Methods Rheumatoid arthritis Salivary gland Salivary glands Single nucleotide polymorphisms Single-nucleotide polymorphism Temporomandibular joint Temporomandibular Joint Disorders - complications Temporomandibular Joint Disorders - genetics Tubules Young Adult |
| title | Aquaporin locus (12q13.12) might contribute to susceptibility of temporomandibular joint disorder associated with periodontitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T08%3A23%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aquaporin%20locus%20(12q13.12)%20might%20contribute%20to%20susceptibility%20of%20temporomandibular%20joint%20disorder%20associated%20with%20periodontitis&rft.jtitle=PloS%20one&rft.au=Bezamat,%20Mariana&rft.date=2020-03-04&rft.volume=15&rft.issue=3&rft.spage=e0229245&rft.pages=e0229245-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0229245&rft_dat=%3Cgale_plos_%3EA616258505%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2371512976&rft_id=info:pmid/32130259&rft_galeid=A616258505&rft_doaj_id=oai_doaj_org_article_836a3598425348d1bf38066f19a35012&rfr_iscdi=true |