Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes
Necrotizing enterocolitis (NEC) is a devastating intestinal emergency that affects ten percent of very low birth weight premature babies and costs society in both expense and heartache. It is probably caused by an inappropriate interaction of colonizing bacteria with an immature intestine. A possibl...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-02, Vol.15 (2), p.e0229283 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | e0229283 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Zheng, Nan Gao, Yanan Zhu, Weishu Meng, Di Walker, W Allan |
| description | Necrotizing enterocolitis (NEC) is a devastating intestinal emergency that affects ten percent of very low birth weight premature babies and costs society in both expense and heartache. It is probably caused by an inappropriate interaction of colonizing bacteria with an immature intestine. A possible preventative measure is to feed prematures their mother's expressed breast milk in conjunction with a probiotic. This synbiotic prevention reduces the severity and incidence of this condition. This study was designed to determine the mechanism of the synbiotic effect in human and mouse fetal intestine. Breast milk interacting with a NEC preventative probiotic such as Bifidobacterium infantis can produce increased levels of short chain fatty acids (acetate, propionate and butyrate) (SCFAs). SCFAs are known to be anti-inflammatory in mature enterocytes and immunocytes. Very little is known about their role in immature intestine. When exposed to a human fetal cell line, fetal intestinal organoids and fetal mouse intestine, these SCFAs were anti-inflammatory. Their mechanism of anti-inflammation differed from those reported for mature cells by involving the G-protein coupled receptor (GPR 109A) and inhibiting histone deacetylase 4 and 5. These bacterial metabolites may help explain the synbiotic anti-inflammatory effect of breast milk and probiotics given to premature infants at risk for NEC. |
| doi_str_mv | 10.1371/journal.pone.0229283 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2360073696</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A614629757</galeid><doaj_id>oai_doaj_org_article_52f7d29c7f0f41e4aadaed26d503ffc3</doaj_id><sourcerecordid>A614629757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-11d21296e5aaffcfdfc5f8052f8ecdf3b5a3d21655c498e4736af0cb8fa027c93</originalsourceid><addsrcrecordid>eNqNk22L1DAQx4so3nn6DUQDguCLXdOkj2-E4_Bh4eDAU9-G2Txss7bNmqR66yfyYzp1e8cWFKQvMpn85j-TaSZJnqZ0mfIyfb11g--hXe5cr5eUsZpV_F5ymtacLQpG-f0j-yR5FMKW0pxXRfEwOeGMVhmj7DT5dd04H4lswPbEQIx7AtKqQHbeqUFqRdZ7Il3revvT9hti-6hDtJgYvV2n-4DWGmTU3qI1HnvcWdeTHzY2RN_svA5h1PEaQiSdbb8S8JpAH-3C9qaFroPo_B6DSTN00BM7egZk9Cjn5B5zPk4eGGiDfjKtZ8nnd28_XXxYXF69X12cXy5kUbO4SFPFUlYXOgcwRhplZG4qmjNTaakMX-fAkSjyXGZ1pbOSF2CoXFcGKCtlzc-S5wfdXeuCmJocBOMFpQjXBRKrA6EcbMXO2w78Xjiw4o_D-Y0AH61stcC0pWK1LA01WaozAAVasULllGN1HLXeTNmGdaeVxAt7aGei85PeNmLjvouS8qzKx2JeTALefRvw1_yj5InaAFaFTXcoJjsbpDgv0qxgdZmXSC3_QuGndGclPjNj0T8LeDULQCbqm7iBIQSxuv74_-zVlzn78ohtNLSxCa4dxmcV5mB2AKV3IXht7jqXUjFOyW03xDglYpoSDHt23PW7oNux4L8BVdUTsw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2360073696</pqid></control><display><type>article</type><title>Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Zheng, Nan ; Gao, Yanan ; Zhu, Weishu ; Meng, Di ; Walker, W Allan</creator><contributor>Nie, Daotai</contributor><creatorcontrib>Zheng, Nan ; Gao, Yanan ; Zhu, Weishu ; Meng, Di ; Walker, W Allan ; Nie, Daotai</creatorcontrib><description>Necrotizing enterocolitis (NEC) is a devastating intestinal emergency that affects ten percent of very low birth weight premature babies and costs society in both expense and heartache. It is probably caused by an inappropriate interaction of colonizing bacteria with an immature intestine. A possible preventative measure is to feed prematures their mother's expressed breast milk in conjunction with a probiotic. This synbiotic prevention reduces the severity and incidence of this condition. This study was designed to determine the mechanism of the synbiotic effect in human and mouse fetal intestine. Breast milk interacting with a NEC preventative probiotic such as Bifidobacterium infantis can produce increased levels of short chain fatty acids (acetate, propionate and butyrate) (SCFAs). SCFAs are known to be anti-inflammatory in mature enterocytes and immunocytes. Very little is known about their role in immature intestine. When exposed to a human fetal cell line, fetal intestinal organoids and fetal mouse intestine, these SCFAs were anti-inflammatory. Their mechanism of anti-inflammation differed from those reported for mature cells by involving the G-protein coupled receptor (GPR 109A) and inhibiting histone deacetylase 4 and 5. These bacterial metabolites may help explain the synbiotic anti-inflammatory effect of breast milk and probiotics given to premature infants at risk for NEC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0229283</identifier><identifier>PMID: 32084202</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acetic acid ; Animal sciences ; Animals ; Anti-inflammatory agents ; Anti-Inflammatory Agents - metabolism ; Anti-Inflammatory Agents - pharmacology ; Authorship ; Babies ; Bacteria ; Bifidobacterium longum subspecies infantis - physiology ; Biology ; Biology and Life Sciences ; Birth weight ; Breast ; Breast milk ; Breastfeeding & lactation ; Colon ; Enterocolitis ; Enterocytes ; Enterocytes - cytology ; Enterocytes - drug effects ; Enterocytes - metabolism ; Enzyme Induction - drug effects ; Enzymes ; Esters ; Experiments ; Fatty acids ; Fatty Acids, Volatile - biosynthesis ; Fatty Acids, Volatile - pharmacology ; Fetus - microbiology ; Fetuses ; G protein-coupled receptors ; Gastrointestinal diseases ; Gene expression ; Histone deacetylase ; Histone Deacetylases - genetics ; Humans ; Immunology ; Infants ; Inflammation ; Interleukin-1beta - metabolism ; Interleukin-8 - metabolism ; Intestine ; Intestines - cytology ; Intestines - microbiology ; Kinases ; Laboratories ; Legal fees ; Low birth weight ; Medical research ; Medicine and Health Sciences ; Mepenzolate ; Metabolites ; Mice ; Milk ; Milk, Human - microbiology ; Mutagenesis, Insertional - drug effects ; Necrosis ; Necrotizing enterocolitis ; Organoids ; Organoids - drug effects ; Organoids - metabolism ; Pathogenesis ; Physical Sciences ; Premature infants ; Probiotics ; Propionic acid ; Receptors, G-Protein-Coupled - metabolism ; Research and Analysis Methods ; Small intestine ; Software industry</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0229283</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Zheng et al 2020 Zheng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-11d21296e5aaffcfdfc5f8052f8ecdf3b5a3d21655c498e4736af0cb8fa027c93</citedby><cites>FETCH-LOGICAL-c692t-11d21296e5aaffcfdfc5f8052f8ecdf3b5a3d21655c498e4736af0cb8fa027c93</cites><orcidid>0000-0003-0828-8224</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034856/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034856/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32084202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nie, Daotai</contributor><creatorcontrib>Zheng, Nan</creatorcontrib><creatorcontrib>Gao, Yanan</creatorcontrib><creatorcontrib>Zhu, Weishu</creatorcontrib><creatorcontrib>Meng, Di</creatorcontrib><creatorcontrib>Walker, W Allan</creatorcontrib><title>Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Necrotizing enterocolitis (NEC) is a devastating intestinal emergency that affects ten percent of very low birth weight premature babies and costs society in both expense and heartache. It is probably caused by an inappropriate interaction of colonizing bacteria with an immature intestine. A possible preventative measure is to feed prematures their mother's expressed breast milk in conjunction with a probiotic. This synbiotic prevention reduces the severity and incidence of this condition. This study was designed to determine the mechanism of the synbiotic effect in human and mouse fetal intestine. Breast milk interacting with a NEC preventative probiotic such as Bifidobacterium infantis can produce increased levels of short chain fatty acids (acetate, propionate and butyrate) (SCFAs). SCFAs are known to be anti-inflammatory in mature enterocytes and immunocytes. Very little is known about their role in immature intestine. When exposed to a human fetal cell line, fetal intestinal organoids and fetal mouse intestine, these SCFAs were anti-inflammatory. Their mechanism of anti-inflammation differed from those reported for mature cells by involving the G-protein coupled receptor (GPR 109A) and inhibiting histone deacetylase 4 and 5. These bacterial metabolites may help explain the synbiotic anti-inflammatory effect of breast milk and probiotics given to premature infants at risk for NEC.</description><subject>Acetic acid</subject><subject>Animal sciences</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents - metabolism</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Authorship</subject><subject>Babies</subject><subject>Bacteria</subject><subject>Bifidobacterium longum subspecies infantis - physiology</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Breast</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Colon</subject><subject>Enterocolitis</subject><subject>Enterocytes</subject><subject>Enterocytes - cytology</subject><subject>Enterocytes - drug effects</subject><subject>Enterocytes - metabolism</subject><subject>Enzyme Induction - drug effects</subject><subject>Enzymes</subject><subject>Esters</subject><subject>Experiments</subject><subject>Fatty acids</subject><subject>Fatty Acids, Volatile - biosynthesis</subject><subject>Fatty Acids, Volatile - pharmacology</subject><subject>Fetus - microbiology</subject><subject>Fetuses</subject><subject>G protein-coupled receptors</subject><subject>Gastrointestinal diseases</subject><subject>Gene expression</subject><subject>Histone deacetylase</subject><subject>Histone Deacetylases - genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infants</subject><subject>Inflammation</subject><subject>Interleukin-1beta - metabolism</subject><subject>Interleukin-8 - metabolism</subject><subject>Intestine</subject><subject>Intestines - cytology</subject><subject>Intestines - microbiology</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Legal fees</subject><subject>Low birth weight</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Mepenzolate</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Milk</subject><subject>Milk, Human - microbiology</subject><subject>Mutagenesis, Insertional - drug effects</subject><subject>Necrosis</subject><subject>Necrotizing enterocolitis</subject><subject>Organoids</subject><subject>Organoids - drug effects</subject><subject>Organoids - metabolism</subject><subject>Pathogenesis</subject><subject>Physical Sciences</subject><subject>Premature infants</subject><subject>Probiotics</subject><subject>Propionic acid</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Research and Analysis Methods</subject><subject>Small intestine</subject><subject>Software industry</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk22L1DAQx4so3nn6DUQDguCLXdOkj2-E4_Bh4eDAU9-G2Txss7bNmqR66yfyYzp1e8cWFKQvMpn85j-TaSZJnqZ0mfIyfb11g--hXe5cr5eUsZpV_F5ymtacLQpG-f0j-yR5FMKW0pxXRfEwOeGMVhmj7DT5dd04H4lswPbEQIx7AtKqQHbeqUFqRdZ7Il3revvT9hti-6hDtJgYvV2n-4DWGmTU3qI1HnvcWdeTHzY2RN_svA5h1PEaQiSdbb8S8JpAH-3C9qaFroPo_B6DSTN00BM7egZk9Cjn5B5zPk4eGGiDfjKtZ8nnd28_XXxYXF69X12cXy5kUbO4SFPFUlYXOgcwRhplZG4qmjNTaakMX-fAkSjyXGZ1pbOSF2CoXFcGKCtlzc-S5wfdXeuCmJocBOMFpQjXBRKrA6EcbMXO2w78Xjiw4o_D-Y0AH61stcC0pWK1LA01WaozAAVasULllGN1HLXeTNmGdaeVxAt7aGei85PeNmLjvouS8qzKx2JeTALefRvw1_yj5InaAFaFTXcoJjsbpDgv0qxgdZmXSC3_QuGndGclPjNj0T8LeDULQCbqm7iBIQSxuv74_-zVlzn78ohtNLSxCa4dxmcV5mB2AKV3IXht7jqXUjFOyW03xDglYpoSDHt23PW7oNux4L8BVdUTsw</recordid><startdate>20200221</startdate><enddate>20200221</enddate><creator>Zheng, Nan</creator><creator>Gao, Yanan</creator><creator>Zhu, Weishu</creator><creator>Meng, Di</creator><creator>Walker, W Allan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0828-8224</orcidid></search><sort><creationdate>20200221</creationdate><title>Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes</title><author>Zheng, Nan ; Gao, Yanan ; Zhu, Weishu ; Meng, Di ; Walker, W Allan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-11d21296e5aaffcfdfc5f8052f8ecdf3b5a3d21655c498e4736af0cb8fa027c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic acid</topic><topic>Animal sciences</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents - metabolism</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Authorship</topic><topic>Babies</topic><topic>Bacteria</topic><topic>Bifidobacterium longum subspecies infantis - physiology</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Breast</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Colon</topic><topic>Enterocolitis</topic><topic>Enterocytes</topic><topic>Enterocytes - cytology</topic><topic>Enterocytes - drug effects</topic><topic>Enterocytes - metabolism</topic><topic>Enzyme Induction - drug effects</topic><topic>Enzymes</topic><topic>Esters</topic><topic>Experiments</topic><topic>Fatty acids</topic><topic>Fatty Acids, Volatile - biosynthesis</topic><topic>Fatty Acids, Volatile - pharmacology</topic><topic>Fetus - microbiology</topic><topic>Fetuses</topic><topic>G protein-coupled receptors</topic><topic>Gastrointestinal diseases</topic><topic>Gene expression</topic><topic>Histone deacetylase</topic><topic>Histone Deacetylases - genetics</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infants</topic><topic>Inflammation</topic><topic>Interleukin-1beta - metabolism</topic><topic>Interleukin-8 - metabolism</topic><topic>Intestine</topic><topic>Intestines - cytology</topic><topic>Intestines - microbiology</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Legal fees</topic><topic>Low birth weight</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Mepenzolate</topic><topic>Metabolites</topic><topic>Mice</topic><topic>Milk</topic><topic>Milk, Human - microbiology</topic><topic>Mutagenesis, Insertional - drug effects</topic><topic>Necrosis</topic><topic>Necrotizing enterocolitis</topic><topic>Organoids</topic><topic>Organoids - drug effects</topic><topic>Organoids - metabolism</topic><topic>Pathogenesis</topic><topic>Physical Sciences</topic><topic>Premature infants</topic><topic>Probiotics</topic><topic>Propionic acid</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Research and Analysis Methods</topic><topic>Small intestine</topic><topic>Software industry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Nan</creatorcontrib><creatorcontrib>Gao, Yanan</creatorcontrib><creatorcontrib>Zhu, Weishu</creatorcontrib><creatorcontrib>Meng, Di</creatorcontrib><creatorcontrib>Walker, W Allan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Nan</au><au>Gao, Yanan</au><au>Zhu, Weishu</au><au>Meng, Di</au><au>Walker, W Allan</au><au>Nie, Daotai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-02-21</date><risdate>2020</risdate><volume>15</volume><issue>2</issue><spage>e0229283</spage><pages>e0229283-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Necrotizing enterocolitis (NEC) is a devastating intestinal emergency that affects ten percent of very low birth weight premature babies and costs society in both expense and heartache. It is probably caused by an inappropriate interaction of colonizing bacteria with an immature intestine. A possible preventative measure is to feed prematures their mother's expressed breast milk in conjunction with a probiotic. This synbiotic prevention reduces the severity and incidence of this condition. This study was designed to determine the mechanism of the synbiotic effect in human and mouse fetal intestine. Breast milk interacting with a NEC preventative probiotic such as Bifidobacterium infantis can produce increased levels of short chain fatty acids (acetate, propionate and butyrate) (SCFAs). SCFAs are known to be anti-inflammatory in mature enterocytes and immunocytes. Very little is known about their role in immature intestine. When exposed to a human fetal cell line, fetal intestinal organoids and fetal mouse intestine, these SCFAs were anti-inflammatory. Their mechanism of anti-inflammation differed from those reported for mature cells by involving the G-protein coupled receptor (GPR 109A) and inhibiting histone deacetylase 4 and 5. These bacterial metabolites may help explain the synbiotic anti-inflammatory effect of breast milk and probiotics given to premature infants at risk for NEC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32084202</pmid><doi>10.1371/journal.pone.0229283</doi><tpages>e0229283</tpages><orcidid>https://orcid.org/0000-0003-0828-8224</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-02, Vol.15 (2), p.e0229283 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2360073696 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acetic acid Animal sciences Animals Anti-inflammatory agents Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Authorship Babies Bacteria Bifidobacterium longum subspecies infantis - physiology Biology Biology and Life Sciences Birth weight Breast Breast milk Breastfeeding & lactation Colon Enterocolitis Enterocytes Enterocytes - cytology Enterocytes - drug effects Enterocytes - metabolism Enzyme Induction - drug effects Enzymes Esters Experiments Fatty acids Fatty Acids, Volatile - biosynthesis Fatty Acids, Volatile - pharmacology Fetus - microbiology Fetuses G protein-coupled receptors Gastrointestinal diseases Gene expression Histone deacetylase Histone Deacetylases - genetics Humans Immunology Infants Inflammation Interleukin-1beta - metabolism Interleukin-8 - metabolism Intestine Intestines - cytology Intestines - microbiology Kinases Laboratories Legal fees Low birth weight Medical research Medicine and Health Sciences Mepenzolate Metabolites Mice Milk Milk, Human - microbiology Mutagenesis, Insertional - drug effects Necrosis Necrotizing enterocolitis Organoids Organoids - drug effects Organoids - metabolism Pathogenesis Physical Sciences Premature infants Probiotics Propionic acid Receptors, G-Protein-Coupled - metabolism Research and Analysis Methods Small intestine Software industry |
| title | Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T03%3A01%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Short%20chain%20fatty%20acids%20produced%20by%20colonizing%20intestinal%20commensal%20bacterial%20interaction%20with%20expressed%20breast%20milk%20are%20anti-inflammatory%20in%20human%20immature%20enterocytes&rft.jtitle=PloS%20one&rft.au=Zheng,%20Nan&rft.date=2020-02-21&rft.volume=15&rft.issue=2&rft.spage=e0229283&rft.pages=e0229283-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0229283&rft_dat=%3Cgale_plos_%3EA614629757%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2360073696&rft_id=info:pmid/32084202&rft_galeid=A614629757&rft_doaj_id=oai_doaj_org_article_52f7d29c7f0f41e4aadaed26d503ffc3&rfr_iscdi=true |