Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat

Our study revisits the role of cardiac mitochondrial adjustments during the progression of type 2 diabetes mellitus (T2DM), while considering age and sex as potential confounding factors. We used the Nile Grass rats (NRs) as the animal model. After weaning, animals were fed either a Standard Rodent...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0228710-e0228710
Hauptverfasser:	Schneider, Jillian, Han, Woo Hyun, Matthew, Rebecca, Sauvé, Yves, Lemieux, Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - pathology Animal models Animals Biology and Life Sciences Blood glucose Blood Glucose - metabolism Body mass Body mass index Body size Cardiomyocytes Cardiovascular disease Citrate (si)-Synthase - metabolism Citrate synthase Confounding (Statistics) Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diet Electron Transport Complex IV - metabolism Fasting Fasting - blood Fatty acids Fatty Acids - chemistry Fatty Acids - metabolism Female Females Food habits Glucose Grasses Heart High fat diet Hyperglycemia Insulin Insulin resistance Low fat diet Male Males Medicine and Health Sciences Metabolism Mitochondria Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mortality Murinae NAD - metabolism Oxidation-Reduction Oxidative phosphorylation Oxidative stress Phenotype Phosphorylation Physical Sciences Physiological aspects Physiology Research and Analysis Methods Respiration Sex Sex Characteristics Sexual dimorphism Type 2 diabetes Weaning
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