Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection

Brucellosis remains the most common zoonotic disease globally. Currently no vaccines for humans exist, and conventional brucellosis vaccines for livestock fail to confer complete protection; hence, an improved vaccine is needed. Although Brucella infections primarily occur following a mucosal exposu...

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Veröffentlicht in:	PLoS pathogens 2020-01, Vol.16 (1), p.e1008176-e1008176
Hauptverfasser:	Wang, Hongbin, Hoffman, Carol, Yang, Xinghong, Clapp, Beata, Pascual, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Mucosal Animals Bacterial diseases Bacterial infections Biology and Life Sciences Brucella Brucella abortus - genetics Brucella abortus - immunology Brucella Vaccine - administration & dosage Brucella Vaccine - immunology Brucellosis Brucellosis - immunology Brucellosis - prevention & control CD103 antigen CD4 antigen CD44 antigen CD69 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Depletion Experiments Female Immunogenicity, Vaccine Immunologic Memory Immunological memory Immunology Infections Infectious diseases Interleukin 17 Laboratory animals Livestock Lung Diseases - immunology Lung Diseases - microbiology Lung Diseases - prevention & control Lungs Lymphocytes Lymphocytes T Medicine and Health Sciences Memory cells Mice, Inbred BALB C Mice, Inbred C57BL Mucosa Mutants Mutation Neutralization Parenchyma Pathogens Physical Sciences Research and Analysis Methods Tumor necrosis factor-α Vaccines Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Viral infections Zoonoses γ-Interferon
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