New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives...

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Veröffentlicht in:	PLoS pathogens 2020-01, Vol.16 (1), p.e1008270
Hauptverfasser:	Lupien, Andréanne, Foo, Caroline Shi-Yan, Savina, Svetlana, Vocat, Anthony, Piton, Jérémie, Monakhova, Natalia, Benjak, Andrej, Lamprecht, Dirk A, Steyn, Adrie J C, Pethe, Kevin, Makarov, Vadim A, Cole, Stewart T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry Biology and Life Sciences Cell growth Cross-resistance Cytochrome Cytochrome b Cytochrome bc1 Cytochrome bd Cytochromes Depletion Derivatives Drug development Drug dosages Drug resistance Drug Resistance, Bacterial Electron Transport Complex III - antagonists & inhibitors Electron Transport Complex III - genetics Electron Transport Complex III - metabolism Fluorine Gene sequencing Genomes HIV Human immunodeficiency virus Humans Inhibitors Medical research Medicine and Health Sciences Microbial Sensitivity Tests Microorganisms Minimum inhibitory concentration Mode of action Mutants Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Organic chemistry Oxygen consumption Quinazolines - chemistry Quinazolines - pharmacology Resistant mutant Software Sulfide Sulfides Sulfur Supervision Toxicity Transversion Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology Whole genome sequencing
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