Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain

It was recently suggested that supplying the brain with new neurons could counteract Alzheimer's disease (AD). This provocative idea requires further testing in experimental models in which the molecular basis of disease-induced neuronal regeneration could be investigated. We previously found t...

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Veröffentlicht in:	PLoS biology 2020-01, Vol.18 (1), p.e3000585-e3000585
Hauptverfasser:	Bhattarai, Prabesh, Cosacak, Mehmet Ilyas, Mashkaryan, Violeta, Demir, Sevgican, Popova, Stanislava Dimitrova, Govindarajan, Nambirajan, Brandt, Kerstin, Zhang, Yixin, Chang, Weipang, Ampatzis, Konstantinos, Kizil, Caghan
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid Animal cognition Animals Animals, Genetically Modified Biology and Life Sciences Brain Brain - metabolism Brain - physiology Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell Communication - physiology Cytokines Danio rerio Disease Models, Animal Down-regulation Enzymes Gene expression Genomes Growth factors Interleukin Interleukin 4 Lymphocytes B Male Medicine and Health Sciences Metabolism Mice Mice, Transgenic Molecular modelling Nerve growth factor receptors Nerve Regeneration - genetics Nerve Regeneration - physiology Neural stem cells Neural Stem Cells - pathology Neural Stem Cells - physiology Neurodegenerative diseases Neurogenesis Neurogenesis - physiology Neuroglia - physiology Neuroimmunomodulation - physiology Neuronal Plasticity - physiology Neuronal-glial interactions Neurons Neurons - physiology Neuroplasticity Neurosciences NF-κB protein Plastic properties Plasticity Plasticity (neural) Proteins Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism Regeneration Research and Analysis Methods Serotonin Serotonin - genetics Serotonin - metabolism Signal Transduction - genetics Stem cells Toxicity Tryptophan Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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