Low maternal vitamin D is associated with increased risk of congenital and peri/postnatal transmission of Cytomegalovirus in women with HIV
CMV infection of the fetus or neonate can lead to devastating disease, and there are no effective prevention strategies to date. Vitamin D is a potent immunomodulator, supports antiviral immune responses, and plays an important role in placental immunity. Retrospective cohort study to evaluate the i...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-02, Vol.15 (2), p.e0228900-e0228900 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0228900 |
|---|---|
| container_issue | 2 |
| container_start_page | e0228900 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Bearden, Allison Van Winden, Kristi Frederick, Toni Kono, Naoko Operskalski, Eva Pandian, Raj Barton, Lorayne Stek, Alice Kovacs, Andrea |
| description | CMV infection of the fetus or neonate can lead to devastating disease, and there are no effective prevention strategies to date. Vitamin D is a potent immunomodulator, supports antiviral immune responses, and plays an important role in placental immunity.
Retrospective cohort study to evaluate the impact of low maternal vitamin D on congenital and early postnatal transmission of CMV among HIV-infected, non-breastfeeding women and their HIV exposed but negative infants from an urban HIV clinic. Vitamin D panel was performed on stored maternal plasma obtained near time of delivery. Infant CMV testing at 0-6 months included urine and oral cultures, and/or serum polymerase chain reaction testing.
Cohort included 340 mother-infant pairs (births 1991-2014). Among 38 infants (11%) with a CMV+ test between 0-6 months, 4.7% (14/300) had congenital CMV transmission (CMV+ test 0-3 weeks), and 7.6% (24/315) had peri/postnatal CMV (CMV+ test >3 weeks-6 months). Women with lower calcitriol (1,25-dihydroxyvitamin D), the active form of vitamin D, were more likely to have an infant with congenital (OR 12.2 [95% CI 1.61-92.2] P = 0.02) and peri/postnatal (OR 9.84 [95% CI 2.63-36.8] P = 0.0007) infections in multivariate analyses, independent of maternal HIV viral load and CD4 count.
This study demonstrates an association between inadequate maternal calcitriol during pregnancy and increased congenital and early postnatal acquisition of CMV among non-breastfeeding women with HIV and their HIV negative infants. |
| doi_str_mv | 10.1371/journal.pone.0228900 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_2354740894</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_2463858d590c4a1fb2ff4fe6f068c3e9</doaj_id><sourcerecordid>2355960166</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-ad9d3c97a3a1f21260d0ad5fe686c16094dcfef5863ce481d8b86415164339903</originalsourceid><addsrcrecordid>eNptUstuEzEUHSEQLYU_QGCJDZukfo1jb5BQCjRSpG6AreX4kTrM2IM9k6jf0J_G00yrFnXl6-tzj889OlX1HsE5Igt0votDCqqZdzHYOcSYCwhfVKdIEDxjGJKXj-qT6k3OOwhrwhl7XZ0QXEpG-Gl1u44H0Krejlxg73vV-gAugM9A5Ry1L08GHHx_DXzQyapcrsnnPyA6oGPY2lBmGqCCAZ1N_ryLuQ9qbPVJhdz6nH0MI3p508fWblUT9z4NufCBQ2mEI_vl6vfb6pVTTbbvpvOs-vX928_l5Wx99WO1_Lqe6RqzfqaMMESLhSIKOYwwgwYqUzvLONOIQUGNdtbVnBFtKUeGbzijqEaMEiIEJGfVxyNv18QsJx-zxKSmCwq5oAWxOiJMVDvZJd-qdCOj8vKuEdNWqtR73ViJafGx5qYWUNMiaIOdo0WLg4xrYkXh-jL9Nmxaa7QNxZjmCenTl-Cv5Tbu5QIiDsko9_NEkOLfweZeFlO1bRoVbBzudNeCQcRYgX76D_r8dvSI0inmnKx7EIOgHLN1PyXHbMkpW2Xsw-NFHobuw0T-AYIkz2E</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2354740894</pqid></control><display><type>article</type><title>Low maternal vitamin D is associated with increased risk of congenital and peri/postnatal transmission of Cytomegalovirus in women with HIV</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Bearden, Allison ; Van Winden, Kristi ; Frederick, Toni ; Kono, Naoko ; Operskalski, Eva ; Pandian, Raj ; Barton, Lorayne ; Stek, Alice ; Kovacs, Andrea</creator><contributor>Nevels, Michael</contributor><creatorcontrib>Bearden, Allison ; Van Winden, Kristi ; Frederick, Toni ; Kono, Naoko ; Operskalski, Eva ; Pandian, Raj ; Barton, Lorayne ; Stek, Alice ; Kovacs, Andrea ; Nevels, Michael</creatorcontrib><description>CMV infection of the fetus or neonate can lead to devastating disease, and there are no effective prevention strategies to date. Vitamin D is a potent immunomodulator, supports antiviral immune responses, and plays an important role in placental immunity.
Retrospective cohort study to evaluate the impact of low maternal vitamin D on congenital and early postnatal transmission of CMV among HIV-infected, non-breastfeeding women and their HIV exposed but negative infants from an urban HIV clinic. Vitamin D panel was performed on stored maternal plasma obtained near time of delivery. Infant CMV testing at 0-6 months included urine and oral cultures, and/or serum polymerase chain reaction testing.
Cohort included 340 mother-infant pairs (births 1991-2014). Among 38 infants (11%) with a CMV+ test between 0-6 months, 4.7% (14/300) had congenital CMV transmission (CMV+ test 0-3 weeks), and 7.6% (24/315) had peri/postnatal CMV (CMV+ test >3 weeks-6 months). Women with lower calcitriol (1,25-dihydroxyvitamin D), the active form of vitamin D, were more likely to have an infant with congenital (OR 12.2 [95% CI 1.61-92.2] P = 0.02) and peri/postnatal (OR 9.84 [95% CI 2.63-36.8] P = 0.0007) infections in multivariate analyses, independent of maternal HIV viral load and CD4 count.
This study demonstrates an association between inadequate maternal calcitriol during pregnancy and increased congenital and early postnatal acquisition of CMV among non-breastfeeding women with HIV and their HIV negative infants.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0228900</identifier><identifier>PMID: 32053638</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antiretroviral drugs ; Biology and Life Sciences ; Breast feeding ; Calciferol ; Calcitriol ; CD4 antigen ; Cytomegalovirus ; Disease transmission ; Fetuses ; HIV ; Human immunodeficiency virus ; Immune response ; Immunomodulators ; Infants ; Infections ; Laboratories ; Medicine and Health Sciences ; People and Places ; Physical sciences ; Placenta ; Polymerase chain reaction ; Pregnancy ; Urine ; Vitamin D ; Womens health</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0228900-e0228900</ispartof><rights>2020 Bearden et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Bearden et al 2020 Bearden et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-ad9d3c97a3a1f21260d0ad5fe686c16094dcfef5863ce481d8b86415164339903</citedby><cites>FETCH-LOGICAL-c526t-ad9d3c97a3a1f21260d0ad5fe686c16094dcfef5863ce481d8b86415164339903</cites><orcidid>0000-0002-0560-3375</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018030/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018030/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32053638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nevels, Michael</contributor><creatorcontrib>Bearden, Allison</creatorcontrib><creatorcontrib>Van Winden, Kristi</creatorcontrib><creatorcontrib>Frederick, Toni</creatorcontrib><creatorcontrib>Kono, Naoko</creatorcontrib><creatorcontrib>Operskalski, Eva</creatorcontrib><creatorcontrib>Pandian, Raj</creatorcontrib><creatorcontrib>Barton, Lorayne</creatorcontrib><creatorcontrib>Stek, Alice</creatorcontrib><creatorcontrib>Kovacs, Andrea</creatorcontrib><title>Low maternal vitamin D is associated with increased risk of congenital and peri/postnatal transmission of Cytomegalovirus in women with HIV</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>CMV infection of the fetus or neonate can lead to devastating disease, and there are no effective prevention strategies to date. Vitamin D is a potent immunomodulator, supports antiviral immune responses, and plays an important role in placental immunity.
Retrospective cohort study to evaluate the impact of low maternal vitamin D on congenital and early postnatal transmission of CMV among HIV-infected, non-breastfeeding women and their HIV exposed but negative infants from an urban HIV clinic. Vitamin D panel was performed on stored maternal plasma obtained near time of delivery. Infant CMV testing at 0-6 months included urine and oral cultures, and/or serum polymerase chain reaction testing.
Cohort included 340 mother-infant pairs (births 1991-2014). Among 38 infants (11%) with a CMV+ test between 0-6 months, 4.7% (14/300) had congenital CMV transmission (CMV+ test 0-3 weeks), and 7.6% (24/315) had peri/postnatal CMV (CMV+ test >3 weeks-6 months). Women with lower calcitriol (1,25-dihydroxyvitamin D), the active form of vitamin D, were more likely to have an infant with congenital (OR 12.2 [95% CI 1.61-92.2] P = 0.02) and peri/postnatal (OR 9.84 [95% CI 2.63-36.8] P = 0.0007) infections in multivariate analyses, independent of maternal HIV viral load and CD4 count.
This study demonstrates an association between inadequate maternal calcitriol during pregnancy and increased congenital and early postnatal acquisition of CMV among non-breastfeeding women with HIV and their HIV negative infants.</description><subject>Antiretroviral drugs</subject><subject>Biology and Life Sciences</subject><subject>Breast feeding</subject><subject>Calciferol</subject><subject>Calcitriol</subject><subject>CD4 antigen</subject><subject>Cytomegalovirus</subject><subject>Disease transmission</subject><subject>Fetuses</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Immune response</subject><subject>Immunomodulators</subject><subject>Infants</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Medicine and Health Sciences</subject><subject>People and Places</subject><subject>Physical sciences</subject><subject>Placenta</subject><subject>Polymerase chain reaction</subject><subject>Pregnancy</subject><subject>Urine</subject><subject>Vitamin D</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUstuEzEUHSEQLYU_QGCJDZukfo1jb5BQCjRSpG6AreX4kTrM2IM9k6jf0J_G00yrFnXl6-tzj889OlX1HsE5Igt0votDCqqZdzHYOcSYCwhfVKdIEDxjGJKXj-qT6k3OOwhrwhl7XZ0QXEpG-Gl1u44H0Krejlxg73vV-gAugM9A5Ry1L08GHHx_DXzQyapcrsnnPyA6oGPY2lBmGqCCAZ1N_ryLuQ9qbPVJhdz6nH0MI3p508fWblUT9z4NufCBQ2mEI_vl6vfb6pVTTbbvpvOs-vX928_l5Wx99WO1_Lqe6RqzfqaMMESLhSIKOYwwgwYqUzvLONOIQUGNdtbVnBFtKUeGbzijqEaMEiIEJGfVxyNv18QsJx-zxKSmCwq5oAWxOiJMVDvZJd-qdCOj8vKuEdNWqtR73ViJafGx5qYWUNMiaIOdo0WLg4xrYkXh-jL9Nmxaa7QNxZjmCenTl-Cv5Tbu5QIiDsko9_NEkOLfweZeFlO1bRoVbBzudNeCQcRYgX76D_r8dvSI0inmnKx7EIOgHLN1PyXHbMkpW2Xsw-NFHobuw0T-AYIkz2E</recordid><startdate>20200213</startdate><enddate>20200213</enddate><creator>Bearden, Allison</creator><creator>Van Winden, Kristi</creator><creator>Frederick, Toni</creator><creator>Kono, Naoko</creator><creator>Operskalski, Eva</creator><creator>Pandian, Raj</creator><creator>Barton, Lorayne</creator><creator>Stek, Alice</creator><creator>Kovacs, Andrea</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0560-3375</orcidid></search><sort><creationdate>20200213</creationdate><title>Low maternal vitamin D is associated with increased risk of congenital and peri/postnatal transmission of Cytomegalovirus in women with HIV</title><author>Bearden, Allison ; Van Winden, Kristi ; Frederick, Toni ; Kono, Naoko ; Operskalski, Eva ; Pandian, Raj ; Barton, Lorayne ; Stek, Alice ; Kovacs, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-ad9d3c97a3a1f21260d0ad5fe686c16094dcfef5863ce481d8b86415164339903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antiretroviral drugs</topic><topic>Biology and Life Sciences</topic><topic>Breast feeding</topic><topic>Calciferol</topic><topic>Calcitriol</topic><topic>CD4 antigen</topic><topic>Cytomegalovirus</topic><topic>Disease transmission</topic><topic>Fetuses</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Immune response</topic><topic>Immunomodulators</topic><topic>Infants</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Medicine and Health Sciences</topic><topic>People and Places</topic><topic>Physical sciences</topic><topic>Placenta</topic><topic>Polymerase chain reaction</topic><topic>Pregnancy</topic><topic>Urine</topic><topic>Vitamin D</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bearden, Allison</creatorcontrib><creatorcontrib>Van Winden, Kristi</creatorcontrib><creatorcontrib>Frederick, Toni</creatorcontrib><creatorcontrib>Kono, Naoko</creatorcontrib><creatorcontrib>Operskalski, Eva</creatorcontrib><creatorcontrib>Pandian, Raj</creatorcontrib><creatorcontrib>Barton, Lorayne</creatorcontrib><creatorcontrib>Stek, Alice</creatorcontrib><creatorcontrib>Kovacs, Andrea</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bearden, Allison</au><au>Van Winden, Kristi</au><au>Frederick, Toni</au><au>Kono, Naoko</au><au>Operskalski, Eva</au><au>Pandian, Raj</au><au>Barton, Lorayne</au><au>Stek, Alice</au><au>Kovacs, Andrea</au><au>Nevels, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low maternal vitamin D is associated with increased risk of congenital and peri/postnatal transmission of Cytomegalovirus in women with HIV</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-02-13</date><risdate>2020</risdate><volume>15</volume><issue>2</issue><spage>e0228900</spage><epage>e0228900</epage><pages>e0228900-e0228900</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>CMV infection of the fetus or neonate can lead to devastating disease, and there are no effective prevention strategies to date. Vitamin D is a potent immunomodulator, supports antiviral immune responses, and plays an important role in placental immunity.
Retrospective cohort study to evaluate the impact of low maternal vitamin D on congenital and early postnatal transmission of CMV among HIV-infected, non-breastfeeding women and their HIV exposed but negative infants from an urban HIV clinic. Vitamin D panel was performed on stored maternal plasma obtained near time of delivery. Infant CMV testing at 0-6 months included urine and oral cultures, and/or serum polymerase chain reaction testing.
Cohort included 340 mother-infant pairs (births 1991-2014). Among 38 infants (11%) with a CMV+ test between 0-6 months, 4.7% (14/300) had congenital CMV transmission (CMV+ test 0-3 weeks), and 7.6% (24/315) had peri/postnatal CMV (CMV+ test >3 weeks-6 months). Women with lower calcitriol (1,25-dihydroxyvitamin D), the active form of vitamin D, were more likely to have an infant with congenital (OR 12.2 [95% CI 1.61-92.2] P = 0.02) and peri/postnatal (OR 9.84 [95% CI 2.63-36.8] P = 0.0007) infections in multivariate analyses, independent of maternal HIV viral load and CD4 count.
This study demonstrates an association between inadequate maternal calcitriol during pregnancy and increased congenital and early postnatal acquisition of CMV among non-breastfeeding women with HIV and their HIV negative infants.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32053638</pmid><doi>10.1371/journal.pone.0228900</doi><orcidid>https://orcid.org/0000-0002-0560-3375</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-02, Vol.15 (2), p.e0228900-e0228900 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2354740894 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antiretroviral drugs Biology and Life Sciences Breast feeding Calciferol Calcitriol CD4 antigen Cytomegalovirus Disease transmission Fetuses HIV Human immunodeficiency virus Immune response Immunomodulators Infants Infections Laboratories Medicine and Health Sciences People and Places Physical sciences Placenta Polymerase chain reaction Pregnancy Urine Vitamin D Womens health |
| title | Low maternal vitamin D is associated with increased risk of congenital and peri/postnatal transmission of Cytomegalovirus in women with HIV |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T07%3A58%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20maternal%20vitamin%20D%20is%20associated%20with%20increased%20risk%20of%20congenital%20and%20peri/postnatal%20transmission%20of%20Cytomegalovirus%20in%20women%20with%20HIV&rft.jtitle=PloS%20one&rft.au=Bearden,%20Allison&rft.date=2020-02-13&rft.volume=15&rft.issue=2&rft.spage=e0228900&rft.epage=e0228900&rft.pages=e0228900-e0228900&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0228900&rft_dat=%3Cproquest_plos_%3E2355960166%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2354740894&rft_id=info:pmid/32053638&rft_doaj_id=oai_doaj_org_article_2463858d590c4a1fb2ff4fe6f068c3e9&rfr_iscdi=true |