Detection and quantification of renal fibrosis by computerized tomography

Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility. We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0228626
Hauptverfasser:	Cohen, Eric P, Olson, John D, Tooze, Janet A, Bourland, J Daniel, Dugan, Greg O, Cline, J Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal welfare Animals Area Under Curve Biology and Life Sciences Biomarkers Body Size Calibration Collagen Computed tomography Diagnosis, Computer-Assisted Drug dosages Female Fibrosis Fibrosis - diagnostic imaging Kidney - diagnostic imaging Kidney - pathology Kidneys Laboratory animals Macaca mulatta Magnetic Resonance Imaging Male Medical imaging Medicine Medicine and Health Sciences Models, Animal Phantoms, Imaging Primates Renal cortex Research and Analysis Methods ROC Curve Scanners Sensitivity and Specificity Studies Tomography Tomography, X-Ray Computed Ultrasonic imaging
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