99mTc-MIBI uptake as a marker of mitochondrial membrane potential in cancer cells and effects of MDR1 and verapamil

We investigated the relation of 99mTc-MIBI uptake to mitochondrial membrane potential (MMP) in cancer cell lines and patient-derived tumor cells (PDCs). In T47D and HT29 cells with low MDR1 expression, FCCP dose-dependently reduced MMP and 99mTc-MIBI accumulation in similar patterns with nearly perf...

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Veröffentlicht in:	PloS one 2020, Vol.15 (2), p.e0228848-e0228848
Hauptverfasser:	Park, Jin Won, Hong, Sun-Pyo, Lee, Jin Hee, Moon, Seung Hwan, Cho, Young Seok, Jung, Kyung-Ho, Lee, Jeeyun, Lee, Kyung-Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation ATP Binding Cassette Transporter, Subfamily B - metabolism Biological Transport - physiology Biology and Life Sciences Cancer Cell culture Cell Membrane - metabolism Colon Colon cancer Colorectal cancer Drug Resistance, Multiple - physiology Glycoproteins Health sciences HT29 Cells Humans MDR1 protein Medicine and Health Sciences Membrane potential Membrane Potential, Mitochondrial - physiology Membranes Mitochondria Neoplasms - drug therapy Neoplasms - metabolism Nuclear medicine Plasma membranes Polyclonal antibodies Proteins Radiopharmaceuticals - metabolism Research and analysis methods Technetium Tc 99m Sestamibi - metabolism Tumor cell lines Tumor cells Tumor Cells, Cultured Verapamil Verapamil - pharmacology
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