Identifying a new microRNA signature as a prognostic biomarker in colon cancer

The aim was to identify a novel prognostic miRNA signature for colon cancer (CC) in silico. Data on the expression of miRNAs and relevant clinical information for 407 patients were obtained from The Cancer Genome Atlas (TCGA), and the samples were randomly split into a validation set (n = 203) and t...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0228575-e0228575
Hauptverfasser:	Lv, Yunxia, Duanmu, Jinzhong, Fu, Xiaorui, Li, Taiyuan, Jiang, Qunguang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Bioinformatics Biology and life sciences Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer genetics Cancer patients Chemotherapy Colon Colon cancer Colonic Neoplasms - diagnosis Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colorectal cancer Development and progression Diseases Encyclopedias Female Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Functional analysis Gastrointestinal surgery Gene expression Gene Regulatory Networks Genes Genetic aspects Genomes Genomics Humans Male MAP kinase MAP Kinase Signaling System Medical prognosis Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Nomograms Nomographs Novels Ontology Pathogenesis Patients Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Physical Sciences Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rank tests Regression analysis Regression models Research and Analysis Methods Ribonucleic acid RNA Survival Survival analysis Tissues Training
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