Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
The objective of this study was based on the formulation development of fast dispersible Aceclofenac tablets (100 mg) and to evaluate the influence of pharmaceutical mixtures of directly compressible Avicel PH102 with Mannitol and Ac-di-sol on the compressional, mechanical characteristics and drug r...
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| Veröffentlicht in: | PloS one 2020-02, Vol.15 (2), p.e0223201-e0223201 |
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| creator | Yasmin, Riffat Shoaib, Muhammad Harris Ahmed, Farrukh Rafiq Qazi, Faaiza Ali, Huma Zafar, Farya |
| description | The objective of this study was based on the formulation development of fast dispersible Aceclofenac tablets (100 mg) and to evaluate the influence of pharmaceutical mixtures of directly compressible Avicel PH102 with Mannitol and Ac-di-sol on the compressional, mechanical characteristics and drug release properties. Fast dispersible Aceclofenac formulations were developed by central composite design (CCD). Among them the best possible formulation was selected on the basis of micromeritic properties, appropriate tablet weight and disintegration time for further study. Tablets were directly compressed using manual hydraulic press with a compressional force ranging from 7.2 to 77.2 MN/m2. Pre and post compression studies were performed and the compressed formulations (FA-FF) were assessed for different quality tests. The Heckel and Kawakita equations were applied for determination of compressional behavior of formulations. The quality attributes suggested that formulation (FB) containing avicel PH 102 (20%), mannitol (25%) and ac-di-sol (3%) as best optimized formulation showing better mechanical strength i.e. hardness 35.40 ± 6.93N, tensile strength 0.963 MN/m2, and friability 0.68%. Furthermore, compressional analysis of FB showed lowest PY value 59.520 MN/m2 and Pk value 1.040 MN/m2 indicating plasticity of the material. Formulation FB disintegrated rapidly within 21 seconds and released 99.92% drug after 45 min in phosphate buffer pH 6.8. Results of drug release kinetics showed that all formulations followed Weibull and First-order models in three different dissolution media. Avicel PH102 based formulation mixture exhibit excellent compactional strength with rapid disintegration and quick drug release. |
| doi_str_mv | 10.1371/journal.pone.0223201 |
| format | Article |
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Fast dispersible Aceclofenac formulations were developed by central composite design (CCD). Among them the best possible formulation was selected on the basis of micromeritic properties, appropriate tablet weight and disintegration time for further study. Tablets were directly compressed using manual hydraulic press with a compressional force ranging from 7.2 to 77.2 MN/m2. Pre and post compression studies were performed and the compressed formulations (FA-FF) were assessed for different quality tests. The Heckel and Kawakita equations were applied for determination of compressional behavior of formulations. The quality attributes suggested that formulation (FB) containing avicel PH 102 (20%), mannitol (25%) and ac-di-sol (3%) as best optimized formulation showing better mechanical strength i.e. hardness 35.40 ± 6.93N, tensile strength 0.963 MN/m2, and friability 0.68%. Furthermore, compressional analysis of FB showed lowest PY value 59.520 MN/m2 and Pk value 1.040 MN/m2 indicating plasticity of the material. Formulation FB disintegrated rapidly within 21 seconds and released 99.92% drug after 45 min in phosphate buffer pH 6.8. Results of drug release kinetics showed that all formulations followed Weibull and First-order models in three different dissolution media. Avicel PH102 based formulation mixture exhibit excellent compactional strength with rapid disintegration and quick drug release.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0223201</identifier><identifier>PMID: 32050259</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Bond strength ; Cellulose ; Chemical industry ; Chemistry, Pharmaceutical - methods ; Compressibility ; Compression ; Compression tests ; Compressive Strength ; Design ; Diclofenac - analogs & derivatives ; Diclofenac - chemistry ; Disintegration ; Dispersion ; Drug Compounding - methods ; Drug delivery systems ; Earth Sciences ; Formulations ; Friability ; Hardness ; Hydraulic presses ; Hydrogen bonds ; Kinetics ; Mannitol ; Manufacturing ; Mechanical properties ; Methods ; Pharmaceutical sciences ; Pharmacy ; Phosphates ; Physical Sciences ; Quality assessment ; Quality management ; Solubility ; Stress, Mechanical ; Tablets ; Tablets - chemistry ; Tensile Strength ; Time</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0223201-e0223201</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Yasmin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Fast dispersible Aceclofenac formulations were developed by central composite design (CCD). Among them the best possible formulation was selected on the basis of micromeritic properties, appropriate tablet weight and disintegration time for further study. Tablets were directly compressed using manual hydraulic press with a compressional force ranging from 7.2 to 77.2 MN/m2. Pre and post compression studies were performed and the compressed formulations (FA-FF) were assessed for different quality tests. The Heckel and Kawakita equations were applied for determination of compressional behavior of formulations. The quality attributes suggested that formulation (FB) containing avicel PH 102 (20%), mannitol (25%) and ac-di-sol (3%) as best optimized formulation showing better mechanical strength i.e. hardness 35.40 ± 6.93N, tensile strength 0.963 MN/m2, and friability 0.68%. Furthermore, compressional analysis of FB showed lowest PY value 59.520 MN/m2 and Pk value 1.040 MN/m2 indicating plasticity of the material. Formulation FB disintegrated rapidly within 21 seconds and released 99.92% drug after 45 min in phosphate buffer pH 6.8. Results of drug release kinetics showed that all formulations followed Weibull and First-order models in three different dissolution media. 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Fast dispersible Aceclofenac formulations were developed by central composite design (CCD). Among them the best possible formulation was selected on the basis of micromeritic properties, appropriate tablet weight and disintegration time for further study. Tablets were directly compressed using manual hydraulic press with a compressional force ranging from 7.2 to 77.2 MN/m2. Pre and post compression studies were performed and the compressed formulations (FA-FF) were assessed for different quality tests. The Heckel and Kawakita equations were applied for determination of compressional behavior of formulations. The quality attributes suggested that formulation (FB) containing avicel PH 102 (20%), mannitol (25%) and ac-di-sol (3%) as best optimized formulation showing better mechanical strength i.e. hardness 35.40 ± 6.93N, tensile strength 0.963 MN/m2, and friability 0.68%. Furthermore, compressional analysis of FB showed lowest PY value 59.520 MN/m2 and Pk value 1.040 MN/m2 indicating plasticity of the material. Formulation FB disintegrated rapidly within 21 seconds and released 99.92% drug after 45 min in phosphate buffer pH 6.8. Results of drug release kinetics showed that all formulations followed Weibull and First-order models in three different dissolution media. Avicel PH102 based formulation mixture exhibit excellent compactional strength with rapid disintegration and quick drug release.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32050259</pmid><doi>10.1371/journal.pone.0223201</doi><tpages>e0223201</tpages><orcidid>https://orcid.org/0000-0002-3639-0026</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Anti-Inflammatory Agents, Non-Steroidal - chemistry Bond strength Cellulose Chemical industry Chemistry, Pharmaceutical - methods Compressibility Compression Compression tests Compressive Strength Design Diclofenac - analogs & derivatives Diclofenac - chemistry Disintegration Dispersion Drug Compounding - methods Drug delivery systems Earth Sciences Formulations Friability Hardness Hydraulic presses Hydrogen bonds Kinetics Mannitol Manufacturing Mechanical properties Methods Pharmaceutical sciences Pharmacy Phosphates Physical Sciences Quality assessment Quality management Solubility Stress, Mechanical Tablets Tablets - chemistry Tensile Strength Time |
| title | Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T15%3A14%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aceclofenac%20fast%20dispersible%20tablet%20formulations:%20Effect%20of%20different%20concentration%20levels%20of%20Avicel%20PH102%20on%20the%20compactional,%20mechanical%20and%20drug%20release%20characteristics&rft.jtitle=PloS%20one&rft.au=Yasmin,%20Riffat&rft.date=2020-02-12&rft.volume=15&rft.issue=2&rft.spage=e0223201&rft.epage=e0223201&rft.pages=e0223201-e0223201&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0223201&rft_dat=%3Cgale_plos_%3EA613771025%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2354112697&rft_id=info:pmid/32050259&rft_galeid=A613771025&rft_doaj_id=oai_doaj_org_article_12b44bb6ce994a3db574933ad6c200d9&rfr_iscdi=true |