The Barcelona Brain Health Initiative: Cohort description and first follow-up
The Barcelona Brain Health Initiative is a longitudinal cohort study that began in 2017 and aims to understand and characterize the determinants of brain health maintenance in middle aged adults. A cohort of 4686 individuals between the ages of 40 and 65 years free from any neurological or psychiatr...
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| description | The Barcelona Brain Health Initiative is a longitudinal cohort study that began in 2017 and aims to understand and characterize the determinants of brain health maintenance in middle aged adults. A cohort of 4686 individuals between the ages of 40 and 65 years free from any neurological or psychiatric diseases was established, and we collected extensive demographic, socio-economic information along with measures of self-perceived health and lifestyles (general health, physical activity, cognitive activity, socialization, sleep, nutrition and vital plan). Here we report on the baseline characteristics of the participants, and the results of the one-year follow-up evaluation. Participants were mainly women, highly educated, and with better lifestyles compared with the general population. After one year 60% of participants completed the one-year follow-up, and these were older, with higher educational level and with better lifestyles in some domains. In the absence of any specific interventions to-date, these participants showed small improvements in physical activity and sleep, but decreased adherence to a Mediterranean diet. These changes were negatively associated with baseline scores, and poorer habits at baseline were predictive of an improvement in lifestyle domains. Of the 2353 participants who completed the one-year follow-up, 73 had been diagnosed with new neurological and neuropsychiatric diseases. Changes in vital plan at follow-up, as well as gender, sleep quality and sense of coherence at baseline were shown to be significant risk factors for the onset of these diagnoses. Notably, gender risk factor decreased in importance as we adjusted by sleep habits, suggesting its potential mediator effects. These findings stress the importance of healthy lifestyles in sustaining brain health, and illustrate the individual benefit that can be derived from participation in longitudinal observational studies. Modifiable lifestyles, specifically quality of sleep, may partially mediate the effect of other risk factors in the development of some neuropsychiatric conditions. |
| doi_str_mv | 10.1371/journal.pone.0228754 |
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A cohort of 4686 individuals between the ages of 40 and 65 years free from any neurological or psychiatric diseases was established, and we collected extensive demographic, socio-economic information along with measures of self-perceived health and lifestyles (general health, physical activity, cognitive activity, socialization, sleep, nutrition and vital plan). Here we report on the baseline characteristics of the participants, and the results of the one-year follow-up evaluation. Participants were mainly women, highly educated, and with better lifestyles compared with the general population. After one year 60% of participants completed the one-year follow-up, and these were older, with higher educational level and with better lifestyles in some domains. In the absence of any specific interventions to-date, these participants showed small improvements in physical activity and sleep, but decreased adherence to a Mediterranean diet. These changes were negatively associated with baseline scores, and poorer habits at baseline were predictive of an improvement in lifestyle domains. Of the 2353 participants who completed the one-year follow-up, 73 had been diagnosed with new neurological and neuropsychiatric diseases. Changes in vital plan at follow-up, as well as gender, sleep quality and sense of coherence at baseline were shown to be significant risk factors for the onset of these diagnoses. Notably, gender risk factor decreased in importance as we adjusted by sleep habits, suggesting its potential mediator effects. These findings stress the importance of healthy lifestyles in sustaining brain health, and illustrate the individual benefit that can be derived from participation in longitudinal observational studies. Modifiable lifestyles, specifically quality of sleep, may partially mediate the effect of other risk factors in the development of some neuropsychiatric conditions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0228754</identifier><identifier>PMID: 32045448</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Biology and Life Sciences ; Brain ; Brain - physiology ; Brain research ; Cognitive ability ; Cohort Studies ; Dementia ; Diet ; Disease ; Diseases ; Domains ; Economic indicators ; Educational attainment ; Exercise ; Feedback ; Female ; Follow-Up Studies ; Gender ; Health ; Health care ; Health care policy ; Health Status ; Healthy Lifestyle ; Humans ; Lifestyles ; Longitudinal Studies ; Male ; Mediation ; Medicine and Health Sciences ; Mediterranean diet ; Mental disorders ; Mental Disorders - diagnosis ; Middle Aged ; Middle aged adults ; Nervous System Diseases - diagnosis ; Nutrition ; Observational studies ; Physical activity ; Physical fitness ; Program Evaluation ; Quality of Life ; Questionnaires ; Risk analysis ; Risk factors ; Ryff, Carol D ; Self Report ; Sleep ; Sleep - physiology ; Social networks ; Social Sciences ; Socialization ; Systematic review</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0228754-e0228754</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Cattaneo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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These changes were negatively associated with baseline scores, and poorer habits at baseline were predictive of an improvement in lifestyle domains. Of the 2353 participants who completed the one-year follow-up, 73 had been diagnosed with new neurological and neuropsychiatric diseases. Changes in vital plan at follow-up, as well as gender, sleep quality and sense of coherence at baseline were shown to be significant risk factors for the onset of these diagnoses. Notably, gender risk factor decreased in importance as we adjusted by sleep habits, suggesting its potential mediator effects. These findings stress the importance of healthy lifestyles in sustaining brain health, and illustrate the individual benefit that can be derived from participation in longitudinal observational studies. 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A cohort of 4686 individuals between the ages of 40 and 65 years free from any neurological or psychiatric diseases was established, and we collected extensive demographic, socio-economic information along with measures of self-perceived health and lifestyles (general health, physical activity, cognitive activity, socialization, sleep, nutrition and vital plan). Here we report on the baseline characteristics of the participants, and the results of the one-year follow-up evaluation. Participants were mainly women, highly educated, and with better lifestyles compared with the general population. After one year 60% of participants completed the one-year follow-up, and these were older, with higher educational level and with better lifestyles in some domains. In the absence of any specific interventions to-date, these participants showed small improvements in physical activity and sleep, but decreased adherence to a Mediterranean diet. These changes were negatively associated with baseline scores, and poorer habits at baseline were predictive of an improvement in lifestyle domains. Of the 2353 participants who completed the one-year follow-up, 73 had been diagnosed with new neurological and neuropsychiatric diseases. Changes in vital plan at follow-up, as well as gender, sleep quality and sense of coherence at baseline were shown to be significant risk factors for the onset of these diagnoses. Notably, gender risk factor decreased in importance as we adjusted by sleep habits, suggesting its potential mediator effects. These findings stress the importance of healthy lifestyles in sustaining brain health, and illustrate the individual benefit that can be derived from participation in longitudinal observational studies. Modifiable lifestyles, specifically quality of sleep, may partially mediate the effect of other risk factors in the development of some neuropsychiatric conditions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32045448</pmid><doi>10.1371/journal.pone.0228754</doi><tpages>e0228754</tpages><orcidid>https://orcid.org/0000-0002-7411-6829</orcidid><orcidid>https://orcid.org/0000-0003-0880-7856</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Sociological Abstracts; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Biology and Life Sciences Brain Brain - physiology Brain research Cognitive ability Cohort Studies Dementia Diet Disease Diseases Domains Economic indicators Educational attainment Exercise Feedback Female Follow-Up Studies Gender Health Health care Health care policy Health Status Healthy Lifestyle Humans Lifestyles Longitudinal Studies Male Mediation Medicine and Health Sciences Mediterranean diet Mental disorders Mental Disorders - diagnosis Middle Aged Middle aged adults Nervous System Diseases - diagnosis Nutrition Observational studies Physical activity Physical fitness Program Evaluation Quality of Life Questionnaires Risk analysis Risk factors Ryff, Carol D Self Report Sleep Sleep - physiology Social networks Social Sciences Socialization Systematic review |
| title | The Barcelona Brain Health Initiative: Cohort description and first follow-up |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T19%3A23%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Barcelona%20Brain%20Health%20Initiative:%20Cohort%20description%20and%20first%20follow-up&rft.jtitle=PloS%20one&rft.au=Cattaneo,%20Gabriele&rft.date=2020-02-11&rft.volume=15&rft.issue=2&rft.spage=e0228754&rft.epage=e0228754&rft.pages=e0228754-e0228754&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0228754&rft_dat=%3Cgale_plos_%3EA613690611%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2353555720&rft_id=info:pmid/32045448&rft_galeid=A613690611&rft_doaj_id=oai_doaj_org_article_008cf41d49ec4fc0bc39926f088be6cd&rfr_iscdi=true |