Impact of the BioFire FilmArray gastrointestinal panel on patient care and infection control
Conventional routine PCR testing for gastrointestinal infections is generally based on pathogen related panels specifically requested by clinicians and can be erroneous and time consuming. The BioFire FilmArray gastrointestinal (GI) panel combines 22 pathogens into a single cartridge-based test on a...
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| creator | Machiels, Julian D Cremers, Amelieke J H van Bergen-Verkuyten, Muriël C G T Paardekoper-Strijbosch, Sandra J M Frijns, Kelly C J Wertheim, Heiman F L Rahamat-Langendoen, Janette Melchers, Willem J G |
| description | Conventional routine PCR testing for gastrointestinal infections is generally based on pathogen related panels specifically requested by clinicians and can be erroneous and time consuming. The BioFire FilmArray gastrointestinal (GI) panel combines 22 pathogens into a single cartridge-based test on a random-access system, thereby reducing the turnaround time to less than 2 hours. We described the clinical impact of implementing the BioFire FilmArray on patients with gastroenteritis in our hospital.
Patients attending a Dutch tertiary care center (Radboud University Medical Center), from whom stool samples were obtained, were eligible for inclusion. The clinicians selected one or a combination of different routinely performed PCR panels (bacterial panel, viral panel, clostridium testing, and three parasitic panels) based on clinical history and symptoms. All samples were in parallel tested with the FilmArray. We retrospectively collected patient data regarding infection control and patient management to assess the potential impact of implementing the FilmArray.
In total 182 patients were included. Routine PCR detected one or more pathogens in 52 (28.6%) patients compared to 72 (39.6%) using the FilmArray. Turnaround time (including transport) decreased from median 53 hours for the routine PCR to 16 hours for the FilmArray. Twenty-six patients could have been removed from isolation 29 hours sooner, 3.6 antibiotic days could have been saved and in five patients additional imaging testing (including colonoscopies) could have been prevented.
The theoretical implementation of the BioFire FilmArray GI panel in patients with clinical suspicion of gastroenteritis resulted in a significant better patient management. |
| doi_str_mv | 10.1371/journal.pone.0228596 |
| format | Article |
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Patients attending a Dutch tertiary care center (Radboud University Medical Center), from whom stool samples were obtained, were eligible for inclusion. The clinicians selected one or a combination of different routinely performed PCR panels (bacterial panel, viral panel, clostridium testing, and three parasitic panels) based on clinical history and symptoms. All samples were in parallel tested with the FilmArray. We retrospectively collected patient data regarding infection control and patient management to assess the potential impact of implementing the FilmArray.
In total 182 patients were included. Routine PCR detected one or more pathogens in 52 (28.6%) patients compared to 72 (39.6%) using the FilmArray. Turnaround time (including transport) decreased from median 53 hours for the routine PCR to 16 hours for the FilmArray. Twenty-six patients could have been removed from isolation 29 hours sooner, 3.6 antibiotic days could have been saved and in five patients additional imaging testing (including colonoscopies) could have been prevented.
The theoretical implementation of the BioFire FilmArray GI panel in patients with clinical suspicion of gastroenteritis resulted in a significant better patient management.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0228596</identifier><identifier>PMID: 32027698</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibiotics ; Biology and Life Sciences ; Cartridges ; Child ; Child, Preschool ; Colonoscopy ; Disease control ; Feces - microbiology ; Gastroenteritis ; Gastroenteritis - diagnosis ; Gastroenteritis - microbiology ; Gastrointestinal diseases ; Health aspects ; Health care facilities ; Humans ; Infant ; Infant, Newborn ; Infection ; Infection control ; Infection Control - methods ; Infections ; Infectious diseases ; Isolation ; Male ; Medical centers ; Medical diagnosis ; Medical research ; Medical schools ; Medical tests ; Medicine and Health Sciences ; Middle Aged ; Molecular Diagnostic Techniques - instrumentation ; Molecular Diagnostic Techniques - methods ; Netherlands ; Panels ; Pathogenic microorganisms ; Pathogens ; Patient Care - methods ; Patients ; Polymerase Chain Reaction - methods ; Research and Analysis Methods ; Tertiary Care Centers ; Time ; Time Factors ; Young Adult</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0228596-e0228596</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Machiels et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Machiels et al 2020 Machiels et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6d7480510d8a54ebab2d8e8a8d72161f602f27d7347215cd2ecda51babcdd60a3</citedby><cites>FETCH-LOGICAL-c692t-6d7480510d8a54ebab2d8e8a8d72161f602f27d7347215cd2ecda51babcdd60a3</cites><orcidid>0000-0003-2606-8276</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004333/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004333/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32027698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machiels, Julian D</creatorcontrib><creatorcontrib>Cremers, Amelieke J H</creatorcontrib><creatorcontrib>van Bergen-Verkuyten, Muriël C G T</creatorcontrib><creatorcontrib>Paardekoper-Strijbosch, Sandra J M</creatorcontrib><creatorcontrib>Frijns, Kelly C J</creatorcontrib><creatorcontrib>Wertheim, Heiman F L</creatorcontrib><creatorcontrib>Rahamat-Langendoen, Janette</creatorcontrib><creatorcontrib>Melchers, Willem J G</creatorcontrib><title>Impact of the BioFire FilmArray gastrointestinal panel on patient care and infection control</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Conventional routine PCR testing for gastrointestinal infections is generally based on pathogen related panels specifically requested by clinicians and can be erroneous and time consuming. The BioFire FilmArray gastrointestinal (GI) panel combines 22 pathogens into a single cartridge-based test on a random-access system, thereby reducing the turnaround time to less than 2 hours. We described the clinical impact of implementing the BioFire FilmArray on patients with gastroenteritis in our hospital.
Patients attending a Dutch tertiary care center (Radboud University Medical Center), from whom stool samples were obtained, were eligible for inclusion. The clinicians selected one or a combination of different routinely performed PCR panels (bacterial panel, viral panel, clostridium testing, and three parasitic panels) based on clinical history and symptoms. All samples were in parallel tested with the FilmArray. We retrospectively collected patient data regarding infection control and patient management to assess the potential impact of implementing the FilmArray.
In total 182 patients were included. Routine PCR detected one or more pathogens in 52 (28.6%) patients compared to 72 (39.6%) using the FilmArray. Turnaround time (including transport) decreased from median 53 hours for the routine PCR to 16 hours for the FilmArray. Twenty-six patients could have been removed from isolation 29 hours sooner, 3.6 antibiotic days could have been saved and in five patients additional imaging testing (including colonoscopies) could have been prevented.
The theoretical implementation of the BioFire FilmArray GI panel in patients with clinical suspicion of gastroenteritis resulted in a significant better patient management.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibiotics</subject><subject>Biology and Life Sciences</subject><subject>Cartridges</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colonoscopy</subject><subject>Disease control</subject><subject>Feces - microbiology</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - diagnosis</subject><subject>Gastroenteritis - microbiology</subject><subject>Gastrointestinal diseases</subject><subject>Health aspects</subject><subject>Health care facilities</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infection</subject><subject>Infection control</subject><subject>Infection Control - methods</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Isolation</subject><subject>Male</subject><subject>Medical centers</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medical schools</subject><subject>Medical tests</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Molecular Diagnostic Techniques - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machiels, Julian D</au><au>Cremers, Amelieke J H</au><au>van Bergen-Verkuyten, Muriël C G T</au><au>Paardekoper-Strijbosch, Sandra J M</au><au>Frijns, Kelly C J</au><au>Wertheim, Heiman F L</au><au>Rahamat-Langendoen, Janette</au><au>Melchers, Willem J G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of the BioFire FilmArray gastrointestinal panel on patient care and infection control</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-02-06</date><risdate>2020</risdate><volume>15</volume><issue>2</issue><spage>e0228596</spage><epage>e0228596</epage><pages>e0228596-e0228596</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Conventional routine PCR testing for gastrointestinal infections is generally based on pathogen related panels specifically requested by clinicians and can be erroneous and time consuming. The BioFire FilmArray gastrointestinal (GI) panel combines 22 pathogens into a single cartridge-based test on a random-access system, thereby reducing the turnaround time to less than 2 hours. We described the clinical impact of implementing the BioFire FilmArray on patients with gastroenteritis in our hospital.
Patients attending a Dutch tertiary care center (Radboud University Medical Center), from whom stool samples were obtained, were eligible for inclusion. The clinicians selected one or a combination of different routinely performed PCR panels (bacterial panel, viral panel, clostridium testing, and three parasitic panels) based on clinical history and symptoms. All samples were in parallel tested with the FilmArray. We retrospectively collected patient data regarding infection control and patient management to assess the potential impact of implementing the FilmArray.
In total 182 patients were included. Routine PCR detected one or more pathogens in 52 (28.6%) patients compared to 72 (39.6%) using the FilmArray. Turnaround time (including transport) decreased from median 53 hours for the routine PCR to 16 hours for the FilmArray. Twenty-six patients could have been removed from isolation 29 hours sooner, 3.6 antibiotic days could have been saved and in five patients additional imaging testing (including colonoscopies) could have been prevented.
The theoretical implementation of the BioFire FilmArray GI panel in patients with clinical suspicion of gastroenteritis resulted in a significant better patient management.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32027698</pmid><doi>10.1371/journal.pone.0228596</doi><tpages>e0228596</tpages><orcidid>https://orcid.org/0000-0003-2606-8276</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-02, Vol.15 (2), p.e0228596-e0228596 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2352045424 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Aged Aged, 80 and over Antibiotics Biology and Life Sciences Cartridges Child Child, Preschool Colonoscopy Disease control Feces - microbiology Gastroenteritis Gastroenteritis - diagnosis Gastroenteritis - microbiology Gastrointestinal diseases Health aspects Health care facilities Humans Infant Infant, Newborn Infection Infection control Infection Control - methods Infections Infectious diseases Isolation Male Medical centers Medical diagnosis Medical research Medical schools Medical tests Medicine and Health Sciences Middle Aged Molecular Diagnostic Techniques - instrumentation Molecular Diagnostic Techniques - methods Netherlands Panels Pathogenic microorganisms Pathogens Patient Care - methods Patients Polymerase Chain Reaction - methods Research and Analysis Methods Tertiary Care Centers Time Time Factors Young Adult |
| title | Impact of the BioFire FilmArray gastrointestinal panel on patient care and infection control |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T11%3A27%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20the%20BioFire%20FilmArray%20gastrointestinal%20panel%20on%20patient%20care%20and%20infection%20control&rft.jtitle=PloS%20one&rft.au=Machiels,%20Julian%20D&rft.date=2020-02-06&rft.volume=15&rft.issue=2&rft.spage=e0228596&rft.epage=e0228596&rft.pages=e0228596-e0228596&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0228596&rft_dat=%3Cgale_plos_%3EA613315836%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2352045424&rft_id=info:pmid/32027698&rft_galeid=A613315836&rft_doaj_id=oai_doaj_org_article_d2a737f419cf4ffd9134704ab21411c6&rfr_iscdi=true |