Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk

Obesity has reached epidemic proportions and is often accompanied by elevated levels of pro-inflammatory cytokines that promote many chronic diseases, including cancer. However, not all obese people develop these diseases and it would be very helpful to identify those at high risk early on so that p...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0228633-e0228633
Hauptverfasser:	Elisia, Ingrid, Lam, Vivian, Cho, Brandon, Hay, Mariah, Li, Michael Yu, Kapeluto, Jordanna, Elliott, Tom, Harris, David, Bu, Luke, Jia, William, Leung, Hilary, Mohn, William, Krystal, Gerald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adult Biology and Life Sciences Biomarkers - blood Blood Blood Cells Cancer Case-Control Studies CD28 antigen CD3 antigen CD4 antigen CD8 antigen Cell activation Chemokines Chronic diseases Chronic illnesses Cohort Studies Composition Cytokines Development and progression Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diseases E coli EDTA Endothelial growth factors Epidemics Erythrocytes Female Granulocyte colony-stimulating factor Health aspects Health risks Humans Immune response Immune system Immunity Inflammation Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 17 Interleukin 6 Interleukin 8 Laboratories Leukocytes (granulocytic) Lymphocytes Lymphocytes T Male Markers Medicine and Health Sciences Monocytes Natural killer cells Neoplasms - blood Neoplasms - etiology Obesity Obesity - blood Obesity - complications Parameter identification Prostaglandin E2 Risk Risk Assessment Risk factors T cells Tumor cells Tumors Type 2 diabetes Vascular endothelial growth factor Viral infections γ-Interferon
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