Mycobacterium tuberculosis thymidylate synthase (ThyX) is a target for plumbagin, a natural product with antimycobacterial activity

Plumbagin derived from the plant Plumbago indica, known as Chitrak in India, is an example of a medicinal compound used traditionally to cure a variety of ailments. Previous reports have indicated that it can inhibit the growth of Mycobacterium tuberculosis (Mtb), the causative agent of the deadly d...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0228657-e0228657
Hauptverfasser:	Sarkar, Apurba, Ghosh, Shreya, Shaw, Rahul, Patra, Madhu Manti, Calcuttawala, Fatema, Mukherjee, Noyonika, Das Gupta, Sujoy K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents Biological Products Biology and Life Sciences Cell death Cell Survival - drug effects Deoxyadenine Nucleotides - metabolism Dihydrofolate reductase Diseases Drug resistance Engineering and Technology Enzymes Gene expression Herbal medicine Laboratories Medicine and Health Sciences Mode of action Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Naphthoquinones - pharmacology Naphthoquinones - therapeutic use Natural products Overexpression Pathogenic microorganisms Plumbagin Research and Analysis Methods Restoration Thymidylate synthase Thymidylate Synthase - antagonists & inhibitors Thymine Nucleotides - metabolism Tuberculosis Viability
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