AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression
Autoimmune regulator (AIRE) is a transcriptional regulator that is primarily expressed in medullary epithelial cells, where it induces tissue-specific antigen expression. Under pathological conditions, AIRE expression is induced in epidermal cells and promotes skin tumor development. This study aime...
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| description | Autoimmune regulator (AIRE) is a transcriptional regulator that is primarily expressed in medullary epithelial cells, where it induces tissue-specific antigen expression. Under pathological conditions, AIRE expression is induced in epidermal cells and promotes skin tumor development. This study aimed to clarify the role of AIRE in the pathogenesis of oral squamous cell carcinoma (OSCC). AIRE expression was evaluated in six OSCC cell lines and in OSCC tissue specimens. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was elevated in 293A cells stably expressing AIRE, and conversely, was decreased in AIRE-knockout HSC3 OSCC cells when compared to the respective controls. Upregulation of STAT1, and ICAM in OSCC cells was confirmed in tissue specimens by immunohistochemistry. We provide evidence that AIRE exerts transcriptional control in cooperation with ETS1. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was increased in 293A cells upon Ets1 transfection, and coexpression of AIRE further increased the expression of these proteins. AIRE coprecipitated with ETS1 in a modified immunoprecipitation assay using formaldehyde crosslinking. Chromatin immunoprecipitation and quantitative PCR analysis revealed that promoter fragments of STAT1, ICAM1, CXCL10, and MMP9 were enriched in the AIRE precipitates. These results indicate that AIRE is induced in OSCC and supports cancer-related gene expression in cooperation with ETS1. This is a novel function of AIRE in extrathymic tissues under the pathological condition. |
| doi_str_mv | 10.1371/journal.pone.0222689 |
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Under pathological conditions, AIRE expression is induced in epidermal cells and promotes skin tumor development. This study aimed to clarify the role of AIRE in the pathogenesis of oral squamous cell carcinoma (OSCC). AIRE expression was evaluated in six OSCC cell lines and in OSCC tissue specimens. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was elevated in 293A cells stably expressing AIRE, and conversely, was decreased in AIRE-knockout HSC3 OSCC cells when compared to the respective controls. Upregulation of STAT1, and ICAM in OSCC cells was confirmed in tissue specimens by immunohistochemistry. We provide evidence that AIRE exerts transcriptional control in cooperation with ETS1. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was increased in 293A cells upon Ets1 transfection, and coexpression of AIRE further increased the expression of these proteins. AIRE coprecipitated with ETS1 in a modified immunoprecipitation assay using formaldehyde crosslinking. Chromatin immunoprecipitation and quantitative PCR analysis revealed that promoter fragments of STAT1, ICAM1, CXCL10, and MMP9 were enriched in the AIRE precipitates. These results indicate that AIRE is induced in OSCC and supports cancer-related gene expression in cooperation with ETS1. This is a novel function of AIRE in extrathymic tissues under the pathological condition.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0222689</identifier><identifier>PMID: 32012175</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>AIRE Protein ; Antigens ; Autoimmunity ; Biology and Life Sciences ; Cancer ; Cancer genetics ; Carcinoma ; Carcinoma, Squamous Cell - genetics ; Cell adhesion & migration ; Cell Line, Tumor ; Chromatin ; Chromatin Immunoprecipitation ; Comparative analysis ; Cooperation ; Crosslinking ; CXCL10 protein ; CXCL11 protein ; Dentistry ; Drinking water ; Epithelial cells ; Ets-1 protein ; Formaldehyde ; Gelatinase B ; Gene Expression ; Genes ; Genetic aspects ; HEK293 Cells ; Humans ; Immunohistochemistry ; Immunoprecipitation ; Intercellular adhesion molecule 1 ; Keratin ; Localization ; Maxillofacial surgery ; Medicine and Health Sciences ; Mouth Neoplasms - genetics ; Oral cancer ; Oral squamous cell carcinoma ; Pathogenesis ; Pathology ; Polymer crosslinking ; Polymerase chain reaction ; Precipitates ; Promoter Regions, Genetic ; Proteins ; Proto-Oncogene Protein c-ets-1 - genetics ; Research and Analysis Methods ; Skin ; Skin cancer ; Squamous cell carcinoma ; Stat1 protein ; Supervision ; Tissues ; Tongue ; Transcription ; Transcription Factors - genetics ; Transcriptional Activation ; Transfection ; Tumors</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0222689-e0222689</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Nguyen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Nguyen et al 2020 Nguyen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3d63606c68ee29a425b8f80ad2207e16ea84119f13d80de7e6ef25d4a29fe0e13</citedby><cites>FETCH-LOGICAL-c692t-3d63606c68ee29a425b8f80ad2207e16ea84119f13d80de7e6ef25d4a29fe0e13</cites><orcidid>0000-0001-6894-6175</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996854/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996854/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32012175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mantovani, Roberto</contributor><creatorcontrib>Nguyen, Chi Thi Kim</creatorcontrib><creatorcontrib>Sawangarun, Wanlada</creatorcontrib><creatorcontrib>Mandasari, Masita</creatorcontrib><creatorcontrib>Morita, Kei-Ichi</creatorcontrib><creatorcontrib>Harada, Hiroyuki</creatorcontrib><creatorcontrib>Kayamori, Kou</creatorcontrib><creatorcontrib>Yamaguchi, Akira</creatorcontrib><creatorcontrib>Sakamoto, Kei</creatorcontrib><title>AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Autoimmune regulator (AIRE) is a transcriptional regulator that is primarily expressed in medullary epithelial cells, where it induces tissue-specific antigen expression. Under pathological conditions, AIRE expression is induced in epidermal cells and promotes skin tumor development. This study aimed to clarify the role of AIRE in the pathogenesis of oral squamous cell carcinoma (OSCC). AIRE expression was evaluated in six OSCC cell lines and in OSCC tissue specimens. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was elevated in 293A cells stably expressing AIRE, and conversely, was decreased in AIRE-knockout HSC3 OSCC cells when compared to the respective controls. Upregulation of STAT1, and ICAM in OSCC cells was confirmed in tissue specimens by immunohistochemistry. We provide evidence that AIRE exerts transcriptional control in cooperation with ETS1. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was increased in 293A cells upon Ets1 transfection, and coexpression of AIRE further increased the expression of these proteins. AIRE coprecipitated with ETS1 in a modified immunoprecipitation assay using formaldehyde crosslinking. Chromatin immunoprecipitation and quantitative PCR analysis revealed that promoter fragments of STAT1, ICAM1, CXCL10, and MMP9 were enriched in the AIRE precipitates. These results indicate that AIRE is induced in OSCC and supports cancer-related gene expression in cooperation with ETS1. This is a novel function of AIRE in extrathymic tissues under the pathological condition.</description><subject>AIRE Protein</subject><subject>Antigens</subject><subject>Autoimmunity</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer genetics</subject><subject>Carcinoma</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Cell adhesion & migration</subject><subject>Cell Line, Tumor</subject><subject>Chromatin</subject><subject>Chromatin Immunoprecipitation</subject><subject>Comparative analysis</subject><subject>Cooperation</subject><subject>Crosslinking</subject><subject>CXCL10 protein</subject><subject>CXCL11 protein</subject><subject>Dentistry</subject><subject>Drinking water</subject><subject>Epithelial cells</subject><subject>Ets-1 protein</subject><subject>Formaldehyde</subject><subject>Gelatinase B</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunoprecipitation</subject><subject>Intercellular adhesion molecule 1</subject><subject>Keratin</subject><subject>Localization</subject><subject>Maxillofacial surgery</subject><subject>Medicine and Health Sciences</subject><subject>Mouth Neoplasms - genetics</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Polymer crosslinking</subject><subject>Polymerase chain reaction</subject><subject>Precipitates</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Proto-Oncogene Protein c-ets-1 - genetics</subject><subject>Research and Analysis Methods</subject><subject>Skin</subject><subject>Skin cancer</subject><subject>Squamous cell carcinoma</subject><subject>Stat1 protein</subject><subject>Supervision</subject><subject>Tissues</subject><subject>Tongue</subject><subject>Transcription</subject><subject>Transcription Factors - genetics</subject><subject>Transcriptional Activation</subject><subject>Transfection</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl9rFDEUxQdRbK1-A9EBQfRh1_yZySQvhaVUXSgUWvU1ZJM7s1lmkm0yI_Xbm92dlh3pg-QhIfndc5OTk2VvMZpjWuEvGz8Ep9r51juYI0II4-JZdooFJTNGEH1-tD7JXsW4QaiknLGX2QklCBNclafZ7WJ5c5nbmFtnBg0mzbkPqs3j3aA6P8RcQ9vmWgVtne9UrpzJt8F3vod0ppyGkDfgIIf7bYAYrXevsxe1aiO8Geez7OfXyx8X32dX19-WF4urmWaC9DNqGGWIacYBiFAFKVe85kgZQlAFmIHiBcaixtRwZKACBjUpTaGIqAEBpmfZ-4PutvVRjn5ESWiJKBZFWSRieSCMVxu5DbZT4Y_0ysr9hg-NVKG3ugVJOBPYcKM0IQWvKC_K2lCBcIkU1itIWudjt2HVgdHg-uTTRHR64uxaNv63ZEIwvr_Mp1Eg-LsBYi87G3fuKgfJ6P29BcYFqRL64R_06deNVKPSA6yrfeqrd6JywTDFiIpSJGr-BJWGgc7qFJ7apv1JwedJQWJ6uO8bNcQol7c3_89e_5qyH4_YNai2X0ffDn2KTJyCxQHUwccYoH40GSO5y_6DG3KXfTlmP5W9O_6gx6KHsNO_qvD9JQ</recordid><startdate>20200203</startdate><enddate>20200203</enddate><creator>Nguyen, Chi Thi Kim</creator><creator>Sawangarun, Wanlada</creator><creator>Mandasari, Masita</creator><creator>Morita, Kei-Ichi</creator><creator>Harada, Hiroyuki</creator><creator>Kayamori, Kou</creator><creator>Yamaguchi, Akira</creator><creator>Sakamoto, Kei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6894-6175</orcidid></search><sort><creationdate>20200203</creationdate><title>AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression</title><author>Nguyen, Chi Thi Kim ; Sawangarun, Wanlada ; Mandasari, Masita ; Morita, Kei-Ichi ; Harada, Hiroyuki ; Kayamori, Kou ; Yamaguchi, Akira ; Sakamoto, Kei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3d63606c68ee29a425b8f80ad2207e16ea84119f13d80de7e6ef25d4a29fe0e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>AIRE Protein</topic><topic>Antigens</topic><topic>Autoimmunity</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Cancer genetics</topic><topic>Carcinoma</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Cell adhesion & migration</topic><topic>Cell Line, Tumor</topic><topic>Chromatin</topic><topic>Chromatin Immunoprecipitation</topic><topic>Comparative analysis</topic><topic>Cooperation</topic><topic>Crosslinking</topic><topic>CXCL10 protein</topic><topic>CXCL11 protein</topic><topic>Dentistry</topic><topic>Drinking water</topic><topic>Epithelial cells</topic><topic>Ets-1 protein</topic><topic>Formaldehyde</topic><topic>Gelatinase B</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunoprecipitation</topic><topic>Intercellular adhesion molecule 1</topic><topic>Keratin</topic><topic>Localization</topic><topic>Maxillofacial surgery</topic><topic>Medicine and Health Sciences</topic><topic>Mouth Neoplasms - genetics</topic><topic>Oral cancer</topic><topic>Oral squamous cell carcinoma</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>Polymer crosslinking</topic><topic>Polymerase chain reaction</topic><topic>Precipitates</topic><topic>Promoter Regions, Genetic</topic><topic>Proteins</topic><topic>Proto-Oncogene Protein c-ets-1 - genetics</topic><topic>Research and Analysis Methods</topic><topic>Skin</topic><topic>Skin cancer</topic><topic>Squamous cell carcinoma</topic><topic>Stat1 protein</topic><topic>Supervision</topic><topic>Tissues</topic><topic>Tongue</topic><topic>Transcription</topic><topic>Transcription Factors - genetics</topic><topic>Transcriptional Activation</topic><topic>Transfection</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Chi Thi Kim</creatorcontrib><creatorcontrib>Sawangarun, Wanlada</creatorcontrib><creatorcontrib>Mandasari, Masita</creatorcontrib><creatorcontrib>Morita, Kei-Ichi</creatorcontrib><creatorcontrib>Harada, Hiroyuki</creatorcontrib><creatorcontrib>Kayamori, Kou</creatorcontrib><creatorcontrib>Yamaguchi, Akira</creatorcontrib><creatorcontrib>Sakamoto, Kei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Chi Thi Kim</au><au>Sawangarun, Wanlada</au><au>Mandasari, Masita</au><au>Morita, Kei-Ichi</au><au>Harada, Hiroyuki</au><au>Kayamori, Kou</au><au>Yamaguchi, Akira</au><au>Sakamoto, Kei</au><au>Mantovani, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-02-03</date><risdate>2020</risdate><volume>15</volume><issue>2</issue><spage>e0222689</spage><epage>e0222689</epage><pages>e0222689-e0222689</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Autoimmune regulator (AIRE) is a transcriptional regulator that is primarily expressed in medullary epithelial cells, where it induces tissue-specific antigen expression. Under pathological conditions, AIRE expression is induced in epidermal cells and promotes skin tumor development. This study aimed to clarify the role of AIRE in the pathogenesis of oral squamous cell carcinoma (OSCC). AIRE expression was evaluated in six OSCC cell lines and in OSCC tissue specimens. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was elevated in 293A cells stably expressing AIRE, and conversely, was decreased in AIRE-knockout HSC3 OSCC cells when compared to the respective controls. Upregulation of STAT1, and ICAM in OSCC cells was confirmed in tissue specimens by immunohistochemistry. We provide evidence that AIRE exerts transcriptional control in cooperation with ETS1. Expression of STAT1, ICAM1, CXCL10, CXCL11, and MMP9 was increased in 293A cells upon Ets1 transfection, and coexpression of AIRE further increased the expression of these proteins. AIRE coprecipitated with ETS1 in a modified immunoprecipitation assay using formaldehyde crosslinking. Chromatin immunoprecipitation and quantitative PCR analysis revealed that promoter fragments of STAT1, ICAM1, CXCL10, and MMP9 were enriched in the AIRE precipitates. These results indicate that AIRE is induced in OSCC and supports cancer-related gene expression in cooperation with ETS1. This is a novel function of AIRE in extrathymic tissues under the pathological condition.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32012175</pmid><doi>10.1371/journal.pone.0222689</doi><tpages>e0222689</tpages><orcidid>https://orcid.org/0000-0001-6894-6175</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2350319454 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | AIRE Protein Antigens Autoimmunity Biology and Life Sciences Cancer Cancer genetics Carcinoma Carcinoma, Squamous Cell - genetics Cell adhesion & migration Cell Line, Tumor Chromatin Chromatin Immunoprecipitation Comparative analysis Cooperation Crosslinking CXCL10 protein CXCL11 protein Dentistry Drinking water Epithelial cells Ets-1 protein Formaldehyde Gelatinase B Gene Expression Genes Genetic aspects HEK293 Cells Humans Immunohistochemistry Immunoprecipitation Intercellular adhesion molecule 1 Keratin Localization Maxillofacial surgery Medicine and Health Sciences Mouth Neoplasms - genetics Oral cancer Oral squamous cell carcinoma Pathogenesis Pathology Polymer crosslinking Polymerase chain reaction Precipitates Promoter Regions, Genetic Proteins Proto-Oncogene Protein c-ets-1 - genetics Research and Analysis Methods Skin Skin cancer Squamous cell carcinoma Stat1 protein Supervision Tissues Tongue Transcription Transcription Factors - genetics Transcriptional Activation Transfection Tumors |
| title | AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T16%3A16%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=AIRE%20is%20induced%20in%20oral%20squamous%20cell%20carcinoma%20and%20promotes%20cancer%20gene%20expression&rft.jtitle=PloS%20one&rft.au=Nguyen,%20Chi%20Thi%20Kim&rft.date=2020-02-03&rft.volume=15&rft.issue=2&rft.spage=e0222689&rft.epage=e0222689&rft.pages=e0222689-e0222689&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0222689&rft_dat=%3Cgale_plos_%3EA613103959%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2350319454&rft_id=info:pmid/32012175&rft_galeid=A613103959&rft_doaj_id=oai_doaj_org_article_28691d8dac224873845fd390150a1cbe&rfr_iscdi=true |