Can atopy have a protective effect against cancer?
An increased prevalence of allergies and an increased incidence of breast cancer have been observed. The hypothesis that atopy may have a protective effect against the risk of different types of breast cancer was evaluated. In this study, 11,101 patients (11,101 women with a mean age of 55.2±14.7 ye...
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| Veröffentlicht in: | PloS one 2020-02, Vol.15 (2), p.e0226950-e0226950 |
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| creator | Bożek, Andrzej Jarzab, Jerzy Mielnik, Michal Bogacz, Agnieszka Kozlowska, Renata Mangold, Dominika |
| description | An increased prevalence of allergies and an increased incidence of breast cancer have been observed. The hypothesis that atopy may have a protective effect against the risk of different types of breast cancer was evaluated.
In this study, 11,101 patients (11,101 women with a mean age of 55.2±14.7 years) with different types of breast cancer were tested for allergies. Allergies were confirmed based on the retrospective analysis of allergy diagnostic procedures in patients who had been previously diagnosed with breast cancer. The retrospective prevalence rates of active allergic diseases, including allergic rhinitis, bronchial asthma and atopic dermatitis, were assessed. All patients were also analyzed for bronchial asthma and allergic rhinitis according to the relevant guidelines. A group of healthy control patients was used for the comparisons.
The women with breast cancer had a significantly lower incidence of IgE-mediated allergic diseases than the controls. The odds ratios (ORs) for allergic rhinitis, atopic dermatitis, and bronchial asthma were 0.61 (95% CI: 0.57-0.73), 0.17 (95% CI: 0.11-0.44), and 0.73 (95% CI: 0.65-0.83), respectively. The mean serum concentrations of total IgE were significantly lower in the study population of women with breast cancer than in the patients of the control group (39.2 ± 26.2 kU/L vs. 108.5 ± 38.5 kU/L; p = 0.002).
Our results suggest that the overall incidence of allergies, especially allergic rhinitis, is lower in patients with certain types of cancer than in individuals who did not have cancer. Further studies are needed to confirm our findings. |
| doi_str_mv | 10.1371/JOURNAL.PONE.0226950 |
| format | Article |
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In this study, 11,101 patients (11,101 women with a mean age of 55.2±14.7 years) with different types of breast cancer were tested for allergies. Allergies were confirmed based on the retrospective analysis of allergy diagnostic procedures in patients who had been previously diagnosed with breast cancer. The retrospective prevalence rates of active allergic diseases, including allergic rhinitis, bronchial asthma and atopic dermatitis, were assessed. All patients were also analyzed for bronchial asthma and allergic rhinitis according to the relevant guidelines. A group of healthy control patients was used for the comparisons.
The women with breast cancer had a significantly lower incidence of IgE-mediated allergic diseases than the controls. The odds ratios (ORs) for allergic rhinitis, atopic dermatitis, and bronchial asthma were 0.61 (95% CI: 0.57-0.73), 0.17 (95% CI: 0.11-0.44), and 0.73 (95% CI: 0.65-0.83), respectively. The mean serum concentrations of total IgE were significantly lower in the study population of women with breast cancer than in the patients of the control group (39.2 ± 26.2 kU/L vs. 108.5 ± 38.5 kU/L; p = 0.002).
Our results suggest that the overall incidence of allergies, especially allergic rhinitis, is lower in patients with certain types of cancer than in individuals who did not have cancer. Further studies are needed to confirm our findings.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/JOURNAL.PONE.0226950</identifier><identifier>PMID: 32015564</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Allergens - blood ; Allergic diseases ; Allergic rhinitis ; Allergies ; Allergy tests ; Analysis ; Asthma ; Asthma - blood ; Asthma - complications ; Asthma - epidemiology ; Atopic dermatitis ; Biology and Life Sciences ; Breast ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - epidemiology ; Cancer ; Cancer research ; Cancer therapies ; Dermatitis ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - complications ; Dermatitis, Atopic - epidemiology ; Dermatology ; Diagnostic systems ; Disease ; Diseases ; Documentation ; Eczema ; Female ; Health risk assessment ; Humans ; Hypersensitivity ; Hypersensitivity - blood ; Hypersensitivity - complications ; Hypersensitivity - epidemiology ; Immunoglobulin E ; Immunoglobulin E - blood ; Medical diagnosis ; Medical research ; Medical tests ; Medicine and Health Sciences ; Middle Aged ; Patients ; Population studies ; Prevalence ; Retrospective Studies ; Rhinitis ; Rhinitis, Allergic, Seasonal - blood ; Rhinitis, Allergic, Seasonal - complications ; Rhinitis, Allergic, Seasonal - epidemiology ; Software ; Studies ; Tumors ; Women ; Women's health ; Womens health</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0226950-e0226950</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Bożek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Bożek et al 2020 Bożek et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9b0590db4f09cccc6c1313e4cd5ad494ee66d66ed7a35b3dd8cdfa589fa78f1c3</citedby><cites>FETCH-LOGICAL-c692t-9b0590db4f09cccc6c1313e4cd5ad494ee66d66ed7a35b3dd8cdfa589fa78f1c3</cites><orcidid>0000-0003-2263-2263</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996965/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996965/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32015564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Karagiannis, Sophia N.</contributor><creatorcontrib>Bożek, Andrzej</creatorcontrib><creatorcontrib>Jarzab, Jerzy</creatorcontrib><creatorcontrib>Mielnik, Michal</creatorcontrib><creatorcontrib>Bogacz, Agnieszka</creatorcontrib><creatorcontrib>Kozlowska, Renata</creatorcontrib><creatorcontrib>Mangold, Dominika</creatorcontrib><title>Can atopy have a protective effect against cancer?</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>An increased prevalence of allergies and an increased incidence of breast cancer have been observed. The hypothesis that atopy may have a protective effect against the risk of different types of breast cancer was evaluated.
In this study, 11,101 patients (11,101 women with a mean age of 55.2±14.7 years) with different types of breast cancer were tested for allergies. Allergies were confirmed based on the retrospective analysis of allergy diagnostic procedures in patients who had been previously diagnosed with breast cancer. The retrospective prevalence rates of active allergic diseases, including allergic rhinitis, bronchial asthma and atopic dermatitis, were assessed. All patients were also analyzed for bronchial asthma and allergic rhinitis according to the relevant guidelines. A group of healthy control patients was used for the comparisons.
The women with breast cancer had a significantly lower incidence of IgE-mediated allergic diseases than the controls. The odds ratios (ORs) for allergic rhinitis, atopic dermatitis, and bronchial asthma were 0.61 (95% CI: 0.57-0.73), 0.17 (95% CI: 0.11-0.44), and 0.73 (95% CI: 0.65-0.83), respectively. The mean serum concentrations of total IgE were significantly lower in the study population of women with breast cancer than in the patients of the control group (39.2 ± 26.2 kU/L vs. 108.5 ± 38.5 kU/L; p = 0.002).
Our results suggest that the overall incidence of allergies, especially allergic rhinitis, is lower in patients with certain types of cancer than in individuals who did not have cancer. Further studies are needed to confirm our findings.</description><subject>Age</subject><subject>Aged</subject><subject>Allergens - blood</subject><subject>Allergic diseases</subject><subject>Allergic rhinitis</subject><subject>Allergies</subject><subject>Allergy tests</subject><subject>Analysis</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - complications</subject><subject>Asthma - epidemiology</subject><subject>Atopic dermatitis</subject><subject>Biology and Life Sciences</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - complications</subject><subject>Dermatitis, Atopic - epidemiology</subject><subject>Dermatology</subject><subject>Diagnostic systems</subject><subject>Disease</subject><subject>Diseases</subject><subject>Documentation</subject><subject>Eczema</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity - blood</subject><subject>Hypersensitivity - complications</subject><subject>Hypersensitivity - epidemiology</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medical tests</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Population studies</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Rhinitis</subject><subject>Rhinitis, Allergic, Seasonal - blood</subject><subject>Rhinitis, Allergic, Seasonal - complications</subject><subject>Rhinitis, Allergic, Seasonal - epidemiology</subject><subject>Software</subject><subject>Studies</subject><subject>Tumors</subject><subject>Women</subject><subject>Women's health</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAUhiMEYmPwDxBEQkJw0WLHH4lvhqpqQFG1osG4tVz7pHWVxsV2JvbvcWk2NWgX2Bf-et732Mcny15iNMakxB--Lq6vLifz8bfF5cUYFQUXDD3KTrEgxYgXiDw-mp9kz0LYIMRIxfnT7IQUCDPG6WlWTFWbq-h2t_la3UCu8p13EXS0aQF1nWa5Winbhphr1WrwH59nT2rVBHjRj2fZ9aeLH9Mvo_ni82w6mY80F0UciSViApklrZHQqXGNCSZAtWHKUEEBODecgykVYUtiTKVNrVglalVWNdbkLHt98N01LsiN63ybwsmCMESwKMoqEbMDYZzayJ23W-VvpVNW_t1wfiWVj1Y3IDGDJEshMXC6LCvBqWaFoMiompSCJ6_zPlq33ILR0EavmoHp8KS1a7lyN5ILwQVnyeBdb-Ddrw5ClFsbNDSNasF1h3sLRBEXCX3zD_rw63pqpdIDbFu7FFfvTeWEp1wiIuieGj9ApW5ga7VrobZpfyB4PxAkJsLvuFJdCHL2_er_2cXPIfv2iF2DauI6uKaL1rVhCNIDqL0LwUN9n2SM5L6077Ihd-n6si_tJHt1_EH3ortaJn8Aup7wbg</recordid><startdate>20200203</startdate><enddate>20200203</enddate><creator>Bożek, Andrzej</creator><creator>Jarzab, Jerzy</creator><creator>Mielnik, Michal</creator><creator>Bogacz, Agnieszka</creator><creator>Kozlowska, Renata</creator><creator>Mangold, Dominika</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2263-2263</orcidid></search><sort><creationdate>20200203</creationdate><title>Can atopy have a protective effect against cancer?</title><author>Bożek, Andrzej ; Jarzab, Jerzy ; Mielnik, Michal ; Bogacz, Agnieszka ; Kozlowska, Renata ; Mangold, Dominika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9b0590db4f09cccc6c1313e4cd5ad494ee66d66ed7a35b3dd8cdfa589fa78f1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Aged</topic><topic>Allergens - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bożek, Andrzej</au><au>Jarzab, Jerzy</au><au>Mielnik, Michal</au><au>Bogacz, Agnieszka</au><au>Kozlowska, Renata</au><au>Mangold, Dominika</au><au>Karagiannis, Sophia N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can atopy have a protective effect against cancer?</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-02-03</date><risdate>2020</risdate><volume>15</volume><issue>2</issue><spage>e0226950</spage><epage>e0226950</epage><pages>e0226950-e0226950</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>An increased prevalence of allergies and an increased incidence of breast cancer have been observed. The hypothesis that atopy may have a protective effect against the risk of different types of breast cancer was evaluated.
In this study, 11,101 patients (11,101 women with a mean age of 55.2±14.7 years) with different types of breast cancer were tested for allergies. Allergies were confirmed based on the retrospective analysis of allergy diagnostic procedures in patients who had been previously diagnosed with breast cancer. The retrospective prevalence rates of active allergic diseases, including allergic rhinitis, bronchial asthma and atopic dermatitis, were assessed. All patients were also analyzed for bronchial asthma and allergic rhinitis according to the relevant guidelines. A group of healthy control patients was used for the comparisons.
The women with breast cancer had a significantly lower incidence of IgE-mediated allergic diseases than the controls. The odds ratios (ORs) for allergic rhinitis, atopic dermatitis, and bronchial asthma were 0.61 (95% CI: 0.57-0.73), 0.17 (95% CI: 0.11-0.44), and 0.73 (95% CI: 0.65-0.83), respectively. The mean serum concentrations of total IgE were significantly lower in the study population of women with breast cancer than in the patients of the control group (39.2 ± 26.2 kU/L vs. 108.5 ± 38.5 kU/L; p = 0.002).
Our results suggest that the overall incidence of allergies, especially allergic rhinitis, is lower in patients with certain types of cancer than in individuals who did not have cancer. Further studies are needed to confirm our findings.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32015564</pmid><doi>10.1371/JOURNAL.PONE.0226950</doi><tpages>e0226950</tpages><orcidid>https://orcid.org/0000-0003-2263-2263</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2020-02, Vol.15 (2), p.e0226950-e0226950 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2350319278 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Allergens - blood Allergic diseases Allergic rhinitis Allergies Allergy tests Analysis Asthma Asthma - blood Asthma - complications Asthma - epidemiology Atopic dermatitis Biology and Life Sciences Breast Breast cancer Breast Neoplasms - blood Breast Neoplasms - epidemiology Cancer Cancer research Cancer therapies Dermatitis Dermatitis, Atopic - blood Dermatitis, Atopic - complications Dermatitis, Atopic - epidemiology Dermatology Diagnostic systems Disease Diseases Documentation Eczema Female Health risk assessment Humans Hypersensitivity Hypersensitivity - blood Hypersensitivity - complications Hypersensitivity - epidemiology Immunoglobulin E Immunoglobulin E - blood Medical diagnosis Medical research Medical tests Medicine and Health Sciences Middle Aged Patients Population studies Prevalence Retrospective Studies Rhinitis Rhinitis, Allergic, Seasonal - blood Rhinitis, Allergic, Seasonal - complications Rhinitis, Allergic, Seasonal - epidemiology Software Studies Tumors Women Women's health Womens health |
| title | Can atopy have a protective effect against cancer? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T08%3A43%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Can%20atopy%20have%20a%20protective%20effect%20against%20cancer?&rft.jtitle=PloS%20one&rft.au=Bo%C5%BCek,%20Andrzej&rft.date=2020-02-03&rft.volume=15&rft.issue=2&rft.spage=e0226950&rft.epage=e0226950&rft.pages=e0226950-e0226950&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/JOURNAL.PONE.0226950&rft_dat=%3Cgale_plos_%3EA613103948%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2350319278&rft_id=info:pmid/32015564&rft_galeid=A613103948&rft_doaj_id=oai_doaj_org_article_15e503e661e64b78964c52940daf3796&rfr_iscdi=true |