Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures
There is limited knowledge about morphological molecular-imaging-derived parameters to further characterize hemodynamically relevant coronary lesions. The aim of this study was to describe and differentiate specific parameters between hemodynamically significant and non-significant coronary lesions...
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| Veröffentlicht in: | PloS one 2020-01, Vol.15 (1), p.e0228292-e0228292 |
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| creator | Engel, Leif-Christopher Landmesser, Ulf Abdelwahed, Youssef S Jaguszewski, Milosz Gigengack, Kevin Wurster, Thomas-Heinrich Skurk, Carsten Manes, Costantina Schuster, Andreas Noutsias, Michel Hamm, Bernd Botnar, Rene M Makowski, Marcus R Bigalke, Boris |
| description | There is limited knowledge about morphological molecular-imaging-derived parameters to further characterize hemodynamically relevant coronary lesions.
The aim of this study was to describe and differentiate specific parameters between hemodynamically significant and non-significant coronary lesions using various invasive and non-invasive measures.
This clinical study analyzed patients with symptoms suggestive of coronary artery disease (CAD) who underwent native T1-weighted CMR and gadofosveset-enhanced CMR as well as invasive coronary angiography. OCT of the culprit vessel to determine the plaque type was performed in a subset of patients. Functional relevance of all lesions was examined using quantitative flow reserve (QFR-angiography). Hemodynamically significant lesions were defined as lesions with a QFR |
| doi_str_mv | 10.1371/journal.pone.0228292 |
| format | Article |
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The aim of this study was to describe and differentiate specific parameters between hemodynamically significant and non-significant coronary lesions using various invasive and non-invasive measures.
This clinical study analyzed patients with symptoms suggestive of coronary artery disease (CAD) who underwent native T1-weighted CMR and gadofosveset-enhanced CMR as well as invasive coronary angiography. OCT of the culprit vessel to determine the plaque type was performed in a subset of patients. Functional relevance of all lesions was examined using quantitative flow reserve (QFR-angiography). Hemodynamically significant lesions were defined as lesions with a QFR <0.8. Signal intensity (contrast-to-noise ratios; CNRs) on native T1-weighted CMR and gadofosveset-enhanced CMR was defined as a measure for intraplaque hemorrhage and endothelial permeability, respectively.
Overall 29 coronary segments from 14 patients were examined. Segments containing lesions with a QFR <0.8 (n = 9) were associated with significantly higher signal enhancement on Gadofosveset-enhanced CMR as compared to segments containing a lesions without significant stenosis (lesion-QFR>0.8; n = 19) (5.32 (4.47-7.02) vs. 2.42 (1.04-5.11); p = 0.042). No differences in signal enhancement were seen on native T1-weighted CMR (2.2 (0.68-6.75) vs. 2.09 (0.91-6.57), p = 0.412). 66.7% (4 out of 6) of all vulnerable plaque and 33.3% (2 out of 6) of all non-vulnerable plaque (fibroatheroma) as assessed by OCT were hemodynamically significant lesions.
The findings of this pilot study suggest that signal enhancement on albumin-binding probe-enhanced CMR but not on T1-weighted CMR is associated with hemodynamically relevant coronary lesions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0228292</identifier><identifier>PMID: 32004345</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Albumin ; Albumins ; Angiography ; Atherosclerosis ; Blood vessels ; Cardiology ; Cardiovascular disease ; Characterization ; Clinical trials ; Contrast agents ; Coronary Angiography ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; Coronary heart disease ; Coronary vessels ; Diagnostic imaging ; Diseases ; Endothelium ; Enzymes ; Female ; Fractional Flow Reserve, Myocardial ; Franklin, Benjamin (1706-1790) ; Gadofosveset ; Gadolinium - administration & dosage ; Heart attacks ; Heart diseases ; Hemodynamics ; Hemorrhage ; Humans ; Lesions ; Magnetic resonance imaging ; Magnetic Resonance Imaging, Cine - methods ; Male ; Measurement methods ; Medical imaging ; Medical imaging equipment ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Multimodal Imaging - methods ; Noise intensity ; Organometallic Compounds - administration & dosage ; Parameters ; Patients ; Permeability ; Physical Sciences ; Pilot Projects ; Questioning ; Research and Analysis Methods ; Segments ; Signs and symptoms ; Stenosis ; Tomography, Optical Coherence</subject><ispartof>PloS one, 2020-01, Vol.15 (1), p.e0228292-e0228292</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Engel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Engel et al 2020 Engel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-7c952d661bd1de089fcb1751c4780a5d98635af0ae3fe02c761908d8e0c8617b3</citedby><cites>FETCH-LOGICAL-c758t-7c952d661bd1de089fcb1751c4780a5d98635af0ae3fe02c761908d8e0c8617b3</cites><orcidid>0000-0002-6079-9913</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994007/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994007/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32004345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bauer, Wolfgang Rudolf</contributor><creatorcontrib>Engel, Leif-Christopher</creatorcontrib><creatorcontrib>Landmesser, Ulf</creatorcontrib><creatorcontrib>Abdelwahed, Youssef S</creatorcontrib><creatorcontrib>Jaguszewski, Milosz</creatorcontrib><creatorcontrib>Gigengack, Kevin</creatorcontrib><creatorcontrib>Wurster, Thomas-Heinrich</creatorcontrib><creatorcontrib>Skurk, Carsten</creatorcontrib><creatorcontrib>Manes, Costantina</creatorcontrib><creatorcontrib>Schuster, Andreas</creatorcontrib><creatorcontrib>Noutsias, Michel</creatorcontrib><creatorcontrib>Hamm, Bernd</creatorcontrib><creatorcontrib>Botnar, Rene M</creatorcontrib><creatorcontrib>Makowski, Marcus R</creatorcontrib><creatorcontrib>Bigalke, Boris</creatorcontrib><title>Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>There is limited knowledge about morphological molecular-imaging-derived parameters to further characterize hemodynamically relevant coronary lesions.
The aim of this study was to describe and differentiate specific parameters between hemodynamically significant and non-significant coronary lesions using various invasive and non-invasive measures.
This clinical study analyzed patients with symptoms suggestive of coronary artery disease (CAD) who underwent native T1-weighted CMR and gadofosveset-enhanced CMR as well as invasive coronary angiography. OCT of the culprit vessel to determine the plaque type was performed in a subset of patients. Functional relevance of all lesions was examined using quantitative flow reserve (QFR-angiography). Hemodynamically significant lesions were defined as lesions with a QFR <0.8. Signal intensity (contrast-to-noise ratios; CNRs) on native T1-weighted CMR and gadofosveset-enhanced CMR was defined as a measure for intraplaque hemorrhage and endothelial permeability, respectively.
Overall 29 coronary segments from 14 patients were examined. Segments containing lesions with a QFR <0.8 (n = 9) were associated with significantly higher signal enhancement on Gadofosveset-enhanced CMR as compared to segments containing a lesions without significant stenosis (lesion-QFR>0.8; n = 19) (5.32 (4.47-7.02) vs. 2.42 (1.04-5.11); p = 0.042). No differences in signal enhancement were seen on native T1-weighted CMR (2.2 (0.68-6.75) vs. 2.09 (0.91-6.57), p = 0.412). 66.7% (4 out of 6) of all vulnerable plaque and 33.3% (2 out of 6) of all non-vulnerable plaque (fibroatheroma) as assessed by OCT were hemodynamically significant lesions.
The findings of this pilot study suggest that signal enhancement on albumin-binding probe-enhanced CMR but not on T1-weighted CMR is associated with hemodynamically relevant coronary lesions.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Albumins</subject><subject>Angiography</subject><subject>Atherosclerosis</subject><subject>Blood vessels</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Characterization</subject><subject>Clinical trials</subject><subject>Contrast agents</subject><subject>Coronary Angiography</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Diagnostic imaging</subject><subject>Diseases</subject><subject>Endothelium</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fractional Flow Reserve, Myocardial</subject><subject>Franklin, Benjamin (1706-1790)</subject><subject>Gadofosveset</subject><subject>Gadolinium - administration & dosage</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Hemodynamics</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging, Cine - methods</subject><subject>Male</subject><subject>Measurement methods</subject><subject>Medical imaging</subject><subject>Medical imaging equipment</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Multimodal Imaging - methods</subject><subject>Noise intensity</subject><subject>Organometallic Compounds - administration & 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multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures</title><author>Engel, Leif-Christopher ; Landmesser, Ulf ; Abdelwahed, Youssef S ; Jaguszewski, Milosz ; Gigengack, Kevin ; Wurster, Thomas-Heinrich ; Skurk, Carsten ; Manes, Costantina ; Schuster, Andreas ; Noutsias, Michel ; Hamm, Bernd ; Botnar, Rene M ; Makowski, Marcus R ; Bigalke, Boris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-7c952d661bd1de089fcb1751c4780a5d98635af0ae3fe02c761908d8e0c8617b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Albumins</topic><topic>Angiography</topic><topic>Atherosclerosis</topic><topic>Blood vessels</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Characterization</topic><topic>Clinical 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engel, Leif-Christopher</au><au>Landmesser, Ulf</au><au>Abdelwahed, Youssef S</au><au>Jaguszewski, Milosz</au><au>Gigengack, Kevin</au><au>Wurster, Thomas-Heinrich</au><au>Skurk, Carsten</au><au>Manes, Costantina</au><au>Schuster, Andreas</au><au>Noutsias, Michel</au><au>Hamm, Bernd</au><au>Botnar, Rene M</au><au>Makowski, Marcus R</au><au>Bigalke, Boris</au><au>Bauer, Wolfgang Rudolf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-01-31</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>e0228292</spage><epage>e0228292</epage><pages>e0228292-e0228292</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There is limited knowledge about morphological molecular-imaging-derived parameters to further characterize hemodynamically relevant coronary lesions.
The aim of this study was to describe and differentiate specific parameters between hemodynamically significant and non-significant coronary lesions using various invasive and non-invasive measures.
This clinical study analyzed patients with symptoms suggestive of coronary artery disease (CAD) who underwent native T1-weighted CMR and gadofosveset-enhanced CMR as well as invasive coronary angiography. OCT of the culprit vessel to determine the plaque type was performed in a subset of patients. Functional relevance of all lesions was examined using quantitative flow reserve (QFR-angiography). Hemodynamically significant lesions were defined as lesions with a QFR <0.8. Signal intensity (contrast-to-noise ratios; CNRs) on native T1-weighted CMR and gadofosveset-enhanced CMR was defined as a measure for intraplaque hemorrhage and endothelial permeability, respectively.
Overall 29 coronary segments from 14 patients were examined. Segments containing lesions with a QFR <0.8 (n = 9) were associated with significantly higher signal enhancement on Gadofosveset-enhanced CMR as compared to segments containing a lesions without significant stenosis (lesion-QFR>0.8; n = 19) (5.32 (4.47-7.02) vs. 2.42 (1.04-5.11); p = 0.042). No differences in signal enhancement were seen on native T1-weighted CMR (2.2 (0.68-6.75) vs. 2.09 (0.91-6.57), p = 0.412). 66.7% (4 out of 6) of all vulnerable plaque and 33.3% (2 out of 6) of all non-vulnerable plaque (fibroatheroma) as assessed by OCT were hemodynamically significant lesions.
The findings of this pilot study suggest that signal enhancement on albumin-binding probe-enhanced CMR but not on T1-weighted CMR is associated with hemodynamically relevant coronary lesions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32004345</pmid><doi>10.1371/journal.pone.0228292</doi><tpages>e0228292</tpages><orcidid>https://orcid.org/0000-0002-6079-9913</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-01, Vol.15 (1), p.e0228292-e0228292 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2349174446 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Albumin Albumins Angiography Atherosclerosis Blood vessels Cardiology Cardiovascular disease Characterization Clinical trials Contrast agents Coronary Angiography Coronary artery Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary heart disease Coronary vessels Diagnostic imaging Diseases Endothelium Enzymes Female Fractional Flow Reserve, Myocardial Franklin, Benjamin (1706-1790) Gadofosveset Gadolinium - administration & dosage Heart attacks Heart diseases Hemodynamics Hemorrhage Humans Lesions Magnetic resonance imaging Magnetic Resonance Imaging, Cine - methods Male Measurement methods Medical imaging Medical imaging equipment Medical research Medicine and Health Sciences Middle Aged Multimodal Imaging - methods Noise intensity Organometallic Compounds - administration & dosage Parameters Patients Permeability Physical Sciences Pilot Projects Questioning Research and Analysis Methods Segments Signs and symptoms Stenosis Tomography, Optical Coherence |
| title | Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T12%3A03%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comprehensive%20multimodality%20characterization%20of%20hemodynamically%20significant%20and%20non-significant%20coronary%20lesions%20using%20invasive%20and%20noninvasive%20measures&rft.jtitle=PloS%20one&rft.au=Engel,%20Leif-Christopher&rft.date=2020-01-31&rft.volume=15&rft.issue=1&rft.spage=e0228292&rft.epage=e0228292&rft.pages=e0228292-e0228292&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0228292&rft_dat=%3Cgale_plos_%3EA612875442%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2349174446&rft_id=info:pmid/32004345&rft_galeid=A612875442&rft_doaj_id=oai_doaj_org_article_972ca0591cc546b0bf9fa1c5cee1db11&rfr_iscdi=true |