Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5

Necroptosis is a form of programmed cell death that is accompanied by release of intracellular contents, and reportedly contributes to various diseases. Here, we investigate the significance of necroptosis in pancreatic cancer. We used immunohistochemistry and western blot analysis to evaluate expre...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0228015
Hauptverfasser:	Ando, Yohei, Ohuchida, Kenoki, Otsubo, Yoshiki, Kibe, Shin, Takesue, Shin, Abe, Toshiya, Iwamoto, Chika, Shindo, Koji, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohtsuka, Takao, Oda, Yoshinao, Nakamura, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amino Acid Chloromethyl Ketones - pharmacology Apoptosis Biochemistry Biology and Life Sciences Cancer Cancer cells Cancer metastasis Cancer prevention Cell adhesion & migration Cell death Cell Line, Tumor Cell migration Cell Movement - drug effects Chemokine CXCL5 - metabolism Chemokines Culture Media, Conditioned - pharmacology CXCR2 protein Diseases Gene Expression Regulation, Neoplastic - drug effects Humans Immunoglobulins Immunohistochemistry Invasiveness Kinases Ligands MAP kinase Medical prognosis Medical research Medical tests Medicine and Health Sciences Middle Aged Morphology Necroptosis Neoplasm Invasiveness Oligopeptides - pharmacology Oncology Pancreas Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phenylurea Compounds - pharmacology Protein arrays Protein kinase Protein kinases Protein Kinases - metabolism Protein-serine/threonine kinase Proteins Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Receptors, Interleukin-8B - metabolism Research and Analysis Methods RNA, Small Interfering - metabolism Surgery Threonine Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumors Up-Regulation - drug effects
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