Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome

Autophagy is a cellular mechanism involved in the bulk degradation of proteins and turnover of organelle. Several studies have shown the significance of autophagy of the renal tubular epithelium in rodent models of tubulointerstitial disorder. However, the role of autophagy in the regulation of huma...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0228337-e0228337
Hauptverfasser:	Ogawa-Akiyama, Ayu, Sugiyama, Hitoshi, Kitagawa, Masashi, Tanaka, Keiko, Kano, Yuzuki, Mise, Koki, Otaka, Nozomu, Tanabe, Katsuyuki, Morinaga, Hiroshi, Kinomura, Masaru, Uchida, Haruhito A, Wada, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Albumin Analysis Animal models Autophagy Biology and Life Sciences Biopsy Case-Control Studies Cell death Cloning Cytoplasm Dentistry Electron microscopy Endocrinology Epithelium Feet Female Fluorescent antibody technique Glomerulonephritis, Membranous - metabolism Glomerulonephritis, Membranous - pathology Hospitals Humans Immunofluorescence Kidney diseases Laboratories Male Medical research Medicine Medicine and Health Sciences Membranous nephropathy Metabolism Microscopy Microtubule-associated protein 1 Microtubule-Associated Proteins - metabolism Middle Aged Multiple regression analysis Nephroblastoma Nephrology Nephropathy Nephrosis, Lipoid - metabolism Nephrosis, Lipoid - pathology Nephrotic syndrome Phagocytosis Pharmaceutical sciences Podocytes - cytology Podocytes - metabolism Population studies Proteins Proteinuria Proteinuria - metabolism Proteolysis Regression analysis Research and Analysis Methods Rheumatology Serum albumin Studies Tumors University graduates Vacuoles Vacuoles - metabolism WT1 protein WT1 Proteins - metabolism Young Adult
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