Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration?

Irradiation of food at 50-55 kGy results in a profound, chronic demyelinating-remyelinating disease of the entire central nervous system (CNS) in cats, named Feline Irradiated Diet-Induced Demyelination (FIDID). This study examines the early stages of demyelination and long-term consequences of demy...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0228109-e0228109
Hauptverfasser:	Radcliff, Abigail B, Heidari, Moones, Field, Aaron S, Duncan, Ian D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animal euthanasia Animals Ataxia Axons Axons - pathology Biology and Life Sciences Cats Cell survival Central nervous system Chronic Disease Cyanocobalamin Death Degeneration Demyelinating Diseases - blood Demyelinating Diseases - pathology Demyelinating Diseases - physiopathology Demyelination Diet Disease Models, Animal Female Food Food irradiation Irradiation Macrophages - pathology Male Medicine and Health Sciences Metabolome Microglia - pathology Myelin Myelin Sheath - metabolism Myelination Nerve Degeneration - blood Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neurodegeneration Neuropathology Nutrient deficiency Physical Sciences Physiological aspects Radiation Remyelination Spinal cord Spinal Cord - pathology Spinal Cord - physiopathology Time Factors Urinary incontinence Veterinary colleges Veterinary medicine Vitamin B 12 - blood Vitamin B12 Vitamin B12 deficiency
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