Activity-dependent switches between dynamic regimes of extracellular matrix expression

Experimental studies highlight the important role of the extracellular matrix (ECM) in the regulation of neuronal excitability and synaptic connectivity in the nervous system. In its turn, the neural ECM is formed in an activity-dependent manner. Its maturation closes the so-called critical period o...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0227917-e0227917
Hauptverfasser:	Lazarevich, Ivan, Stasenko, Sergey, Rozhnova, Maiya, Pankratova, Evgeniya, Dityatev, Alexander, Kazantsev, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - genetics Analysis Animals Artificial neural networks Biology and Life Sciences Bistability Brain Brain - metabolism Computer and Information Sciences Critical period Excitability Extracellular matrix Extracellular Matrix - genetics Gene Expression Regulation - genetics Humans Mathematical models Medicine and Health Sciences Models, Theoretical Nerve Net - metabolism Nervous system Neural networks Neurogenesis - genetics Neuronal Plasticity - genetics Neurons Neurons - metabolism Oscillations Peptide Hydrolases - genetics Physical Sciences Physiological aspects Proteases Receptors Receptors, Cell Surface - genetics Regulation Switches Switching theory Synapses - genetics Synaptic plasticity
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