Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome
Post-thrombotic syndrome (PTS) is a limiting long-term complication present in 20-50% of patients with deep venous thrombosis (DVT) of the lower limbs. A panel of biomarkers with potential relevance to enhance knowledge on the pathophysiology of PTS was investigated. This case-control study included...
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| creator | Bittar, Luis Fernando Silva, Letícia Queiroz da Orsi, Fernanda Loureiro de Andrade Zapponi, Kiara Cristina Senger Mazetto, Bruna de Moraes Paula, Erich Vinícius de Montalvão, Silmara Aparecida de Lima Annichino-Bizzacchi, Joyce Maria |
| description | Post-thrombotic syndrome (PTS) is a limiting long-term complication present in 20-50% of patients with deep venous thrombosis (DVT) of the lower limbs. A panel of biomarkers with potential relevance to enhance knowledge on the pathophysiology of PTS was investigated.
This case-control study included 93 patients with DVT in the lower limbs, 31 with severe PTS (cases) and 62 with mild/no PTS (controls), over 24 months after an acute episode. Thirty-one healthy individuals (HI) with no history of DVT were included as a reference to the population. FVIII activity, D-dimer, inflammatory cytokines, endothelial dysfunction markers, matrix metalloproteinases, and their inhibitors, tissue remodeling and growth factor levels were evaluated. The classification of PTS was, by the Villalta scale.
Patients with severe PTS showed elevated levels of CRP, sICAM-1, sE-selectin, and decreased MMP-9 and MCP-1 levels when compared to patients with mild/no PTS. Moreover, DVT patients presented higher levels of FVIII and D-dimer when compared to HI.
DVT patients present an inflammatory status, endothelial dysfunction and altered proteolysis MMPs activity, even a long time after the acute thrombotic episode, which is more significant in severe PTS. These results suggest a possible role of these mediators in the maintenance and worsening of PTS severity. |
| doi_str_mv | 10.1371/journal.pone.0227150 |
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This case-control study included 93 patients with DVT in the lower limbs, 31 with severe PTS (cases) and 62 with mild/no PTS (controls), over 24 months after an acute episode. Thirty-one healthy individuals (HI) with no history of DVT were included as a reference to the population. FVIII activity, D-dimer, inflammatory cytokines, endothelial dysfunction markers, matrix metalloproteinases, and their inhibitors, tissue remodeling and growth factor levels were evaluated. The classification of PTS was, by the Villalta scale.
Patients with severe PTS showed elevated levels of CRP, sICAM-1, sE-selectin, and decreased MMP-9 and MCP-1 levels when compared to patients with mild/no PTS. Moreover, DVT patients presented higher levels of FVIII and D-dimer when compared to HI.
DVT patients present an inflammatory status, endothelial dysfunction and altered proteolysis MMPs activity, even a long time after the acute thrombotic episode, which is more significant in severe PTS. These results suggest a possible role of these mediators in the maintenance and worsening of PTS severity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0227150</identifier><identifier>PMID: 31945777</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Anticoagulants ; Automation ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; C-Reactive Protein - analysis ; Care and treatment ; Case-Control Studies ; Cell adhesion & migration ; Chemokine CCL2 - blood ; Control methods ; Cytokines ; Dimers ; E-Selectin - blood ; EDTA ; Endothelium ; Factor VIII ; Female ; Fibroblasts ; Gelatinase B ; Growth factors ; Hematology ; Humans ; Hypertension ; Inflammation ; Inflammation - blood ; Intercellular Adhesion Molecule-1 - blood ; Investigations ; Laboratories ; Limbs ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 9 - blood ; Matrix metalloproteinases ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Monocyte chemoattractant protein 1 ; Postthrombotic Syndrome - blood ; Postthrombotic Syndrome - etiology ; Proteins ; Proteolysis ; Quality of life ; Supervision ; Thromboembolism ; Thrombophlebitis ; Thrombosis ; Tumor necrosis factor-TNF ; Venous Thrombosis - complications</subject><ispartof>PloS one, 2020-01, Vol.15 (1), p.e0227150-e0227150</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Bittar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Bittar et al 2020 Bittar et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-6c25780e2fff9f205083493ac7b2f013531503fc601556f2fb71b1b9942ae9093</citedby><cites>FETCH-LOGICAL-c622t-6c25780e2fff9f205083493ac7b2f013531503fc601556f2fb71b1b9942ae9093</cites><orcidid>0000-0003-1632-4678</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964981/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964981/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31945777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bittar, Luis Fernando</creatorcontrib><creatorcontrib>Silva, Letícia Queiroz da</creatorcontrib><creatorcontrib>Orsi, Fernanda Loureiro de Andrade</creatorcontrib><creatorcontrib>Zapponi, Kiara Cristina Senger</creatorcontrib><creatorcontrib>Mazetto, Bruna de Moraes</creatorcontrib><creatorcontrib>Paula, Erich Vinícius de</creatorcontrib><creatorcontrib>Montalvão, Silmara Aparecida de Lima</creatorcontrib><creatorcontrib>Annichino-Bizzacchi, Joyce Maria</creatorcontrib><title>Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Post-thrombotic syndrome (PTS) is a limiting long-term complication present in 20-50% of patients with deep venous thrombosis (DVT) of the lower limbs. A panel of biomarkers with potential relevance to enhance knowledge on the pathophysiology of PTS was investigated.
This case-control study included 93 patients with DVT in the lower limbs, 31 with severe PTS (cases) and 62 with mild/no PTS (controls), over 24 months after an acute episode. Thirty-one healthy individuals (HI) with no history of DVT were included as a reference to the population. FVIII activity, D-dimer, inflammatory cytokines, endothelial dysfunction markers, matrix metalloproteinases, and their inhibitors, tissue remodeling and growth factor levels were evaluated. The classification of PTS was, by the Villalta scale.
Patients with severe PTS showed elevated levels of CRP, sICAM-1, sE-selectin, and decreased MMP-9 and MCP-1 levels when compared to patients with mild/no PTS. Moreover, DVT patients presented higher levels of FVIII and D-dimer when compared to HI.
DVT patients present an inflammatory status, endothelial dysfunction and altered proteolysis MMPs activity, even a long time after the acute thrombotic episode, which is more significant in severe PTS. These results suggest a possible role of these mediators in the maintenance and worsening of PTS severity.</description><subject>Adult</subject><subject>Anticoagulants</subject><subject>Automation</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Cell adhesion & migration</subject><subject>Chemokine CCL2 - blood</subject><subject>Control methods</subject><subject>Cytokines</subject><subject>Dimers</subject><subject>E-Selectin - blood</subject><subject>EDTA</subject><subject>Endothelium</subject><subject>Factor VIII</subject><subject>Female</subject><subject>Fibroblasts</subject><subject>Gelatinase B</subject><subject>Growth factors</subject><subject>Hematology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Inflammation - 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blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Cell adhesion & migration</topic><topic>Chemokine CCL2 - blood</topic><topic>Control methods</topic><topic>Cytokines</topic><topic>Dimers</topic><topic>E-Selectin - blood</topic><topic>EDTA</topic><topic>Endothelium</topic><topic>Factor VIII</topic><topic>Female</topic><topic>Fibroblasts</topic><topic>Gelatinase B</topic><topic>Growth factors</topic><topic>Hematology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Investigations</topic><topic>Laboratories</topic><topic>Limbs</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Matrix metalloproteinases</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Postthrombotic Syndrome - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bittar, Luis Fernando</au><au>Silva, Letícia Queiroz da</au><au>Orsi, Fernanda Loureiro de Andrade</au><au>Zapponi, Kiara Cristina Senger</au><au>Mazetto, Bruna de Moraes</au><au>Paula, Erich Vinícius de</au><au>Montalvão, Silmara Aparecida de Lima</au><au>Annichino-Bizzacchi, Joyce Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-01-16</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>e0227150</spage><epage>e0227150</epage><pages>e0227150-e0227150</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Post-thrombotic syndrome (PTS) is a limiting long-term complication present in 20-50% of patients with deep venous thrombosis (DVT) of the lower limbs. A panel of biomarkers with potential relevance to enhance knowledge on the pathophysiology of PTS was investigated.
This case-control study included 93 patients with DVT in the lower limbs, 31 with severe PTS (cases) and 62 with mild/no PTS (controls), over 24 months after an acute episode. Thirty-one healthy individuals (HI) with no history of DVT were included as a reference to the population. FVIII activity, D-dimer, inflammatory cytokines, endothelial dysfunction markers, matrix metalloproteinases, and their inhibitors, tissue remodeling and growth factor levels were evaluated. The classification of PTS was, by the Villalta scale.
Patients with severe PTS showed elevated levels of CRP, sICAM-1, sE-selectin, and decreased MMP-9 and MCP-1 levels when compared to patients with mild/no PTS. Moreover, DVT patients presented higher levels of FVIII and D-dimer when compared to HI.
DVT patients present an inflammatory status, endothelial dysfunction and altered proteolysis MMPs activity, even a long time after the acute thrombotic episode, which is more significant in severe PTS. These results suggest a possible role of these mediators in the maintenance and worsening of PTS severity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31945777</pmid><doi>10.1371/journal.pone.0227150</doi><tpages>e0227150</tpages><orcidid>https://orcid.org/0000-0003-1632-4678</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-01, Vol.15 (1), p.e0227150-e0227150 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2339783891 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Anticoagulants Automation Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood C-Reactive Protein - analysis Care and treatment Case-Control Studies Cell adhesion & migration Chemokine CCL2 - blood Control methods Cytokines Dimers E-Selectin - blood EDTA Endothelium Factor VIII Female Fibroblasts Gelatinase B Growth factors Hematology Humans Hypertension Inflammation Inflammation - blood Intercellular Adhesion Molecule-1 - blood Investigations Laboratories Limbs Male Matrix metalloproteinase Matrix Metalloproteinase 9 - blood Matrix metalloproteinases Medical research Medicine and Health Sciences Middle Aged Monocyte chemoattractant protein 1 Postthrombotic Syndrome - blood Postthrombotic Syndrome - etiology Proteins Proteolysis Quality of life Supervision Thromboembolism Thrombophlebitis Thrombosis Tumor necrosis factor-TNF Venous Thrombosis - complications |
| title | Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T07%3A28%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20inflammation%20and%20endothelial%20markers%20in%20patients%20with%20late%20severe%20post-thrombotic%20syndrome&rft.jtitle=PloS%20one&rft.au=Bittar,%20Luis%20Fernando&rft.date=2020-01-16&rft.volume=15&rft.issue=1&rft.spage=e0227150&rft.epage=e0227150&rft.pages=e0227150-e0227150&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0227150&rft_dat=%3Cgale_plos_%3EA611503725%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2339783891&rft_id=info:pmid/31945777&rft_galeid=A611503725&rft_doaj_id=oai_doaj_org_article_488e355e5ee84d61af415737c21870b9&rfr_iscdi=true |