Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation

Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear. We show by immunohistochemistry that pepsin positivity occurs in a significant proportion of huma...

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Veröffentlicht in:	PloS one 2020, Vol.15 (1), p.e0227408-e0227408
Hauptverfasser:	Niu, Kai, Guo, Chunjie, Teng, Shiyong, Zhou, Dandan, Yu, Shuyuan, Yin, Wanzhong, Wang, Ping, Zhu, Wei, Duan, Maoli
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biology and Life Sciences Biotechnology Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cytokines Esophagus Female Flow cytometry G1 Phase Gene expression Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Male Medicine and Health Sciences Metastases Microscopy Middle Aged Neoplasm Metastasis Neoplasm Proteins - metabolism NF-κB protein Otolaryngology Pepsin Pepsin A - metabolism Pepsin A - pharmacology Pharyngeal Neoplasms - metabolism Pharyngeal Neoplasms - pathology Research and Analysis Methods Risk analysis Risk factors S Phase Signal Transduction Signaling Squamous cell carcinoma Supervision Surgery
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